Acceleration of Tooth Movement Using PRP and Photobiomodulation With Clear Aligners

NCT07795073 | Not Yet Recruiting Phase 1

• 1 other identifier: Acceleration Clear Aligner
• Study Type: interventional
• Target: 42
• Locations: 1 country
• Sites: 1

Brief Summary

This study compares the effectiveness of two adjunct therapies- photobiomodulation (low-level laser therapy) (PBM) and localized platelet-rich plasma (PRP) injections in accelerating orthodontic tooth movement. Participants receiving clear aligner therapy will be randomly assigned to one of three groups: clear aligners with PBM, clear aligners with PRP, or clear aligners alone (control group). The goal is to evaluate the efficiency, tooth movement tracking and safety.

Conditions

Orthodontic Tooth Movement

Keywords

clear aliginer; low- level laser therapy; PRP; Accelerated tooth movement; orthodontics

Outcome Measures

Primary Outcomes (1)

• Rate of clinical tooth movement via intraoral digital scans

  Quantitative measurement of cumulative linear displacement and dental crown movement (in millimeters) calculated after every 2- aligners sequence (every 4 weeks) measurement will be obtained using digital intra-oral scan superimposed across all three study groups.

  Every 4 weeks from baseline up to 6 months

Secondary Outcomes (4)

• Root apex displacement

  Baseline and 6 months

• Patient-Reported Pain Level

  At baseline, 24 hours, 48 hours, day 3, day 7 and day at aligner change up to 6 months.

• Root resorption

  Baseline and 6 months

• Peri-tooth alveolar bone density

  Baseline and 6 months

Study Arms (3)

Clear Aligner + Photobiomodulation

EXPERIMENTAL

under a reduced wear-time framework.

Device: photobiomodulation (PBM) Therapy; Device: clear aligner(12-hour wear protocol)

Clear Aligner + Plasma Injection

EXPERIMENTAL

under a reduced wear-time framework

Biological: Platelet Rich Plasma (PRP) injection; Device: clear aligner(12-hour wear protocol)

Clear Aligner Control Group

ACTIVE COMPARATOR

without any accelerator intervention

Device: Clear aligner(22-hour wear protocol)

Interventions

Platelet Rich Plasma (PRP) injection BIOLOGICAL

local submucosal injection of Autologous Platelet Rich Plasma (PRP) into the targeted alveolar site to evaluate its clinical effectiveness in accelerating orthodontic tooth movement

Clear Aligner + Plasma Injection

photobiomodulation (PBM) Therapy DEVICE

extra-oral application of photobiomodulation (PBM) Therapy to the targeted alveolar site to evaluate its clinical effectiveness in accelerating orthodontic tooth movement

Clear Aligner + Photobiomodulation

clear aligner(12-hour wear protocol) DEVICE

Clear aligner worn for 22-hour on the first day of each aligner stage, followed by a daily wear duration of 12-hour per day for the remaining period in combination with acceleration modalities

Clear Aligner + Photobiomodulation; Clear Aligner + Plasma Injection

Clear aligner(22-hour wear protocol) DEVICE

Clear aligners worn for the standard conventional duration of 22-hour per day without additional acceleration interventions

Clear Aligner Control Group

Eligibility Criteria

• Age: 18 Years - 25 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Age 18- 25 years requiring clear aligner therapy
• good oral hygiene and health periodontal status
• full permanent dentition (excluding third molars)
• willingness to comply with clear aligner wear schedules and follow -up visits.

You may not qualify if:

• history of previous orthodontic treatment
• Systemic diseases or conditions affecting bone metabolism
• Ongoing pharmacological treatment able to influence orthodontic movement (e.g. prostaglandin inhibitors or biphosphonates)
• Active periodontal disease or poor oral hygiene
• history of photosensitivity or diseases triggered by light exposure
• contraindication to PRP blood extraction

Sponsors & Collaborators

• Sana'a University: lead

Study Sites (1)

Faculty of Dentistry Sanaa university

Sanaa, Sanaa Governorate, 009671, Yemen

Location

MeSH Terms

Interventions

Injections; Low-Level Light Therapy; Therapeutics

Intervention Hierarchy (Ancestors)

Drug Administration Routes; Drug Therapy; Laser Therapy; Phototherapy

Study Officials

• Arij L Abdulmajid, MSc

  Sanaa University

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Naela M Al-mogahed, Prof

CONTACT

+967777962002; almogahed2000@yahoo.com

Study Design

• Study Type: interventional
• Phase: phase 1
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Masking Details: This is a single-blind study. the outcome assessor and data analyst are blinded to group allocations. blinding the clinician and participants was not feasible due to the nature of PRP and photobiomodulation application.
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: PhD student

Model Details: Trial with three independent groups

Study Record Dates

• First Submitted: August 17, 2026
• First Posted: August 31, 2026
• Study Start: September 1, 2026
• Primary Completion (Estimated): April 1, 2027
• Study Completion (Estimated): May 1, 2027
• Last Updated: August 31, 2026

Record last verified: 2026-08

Locations

YE (1)