Effectiveness of Olive Oil Local Application in Orthodontic Patients.

NCT05040620 | Unknown Phase 1 DMC

• 1 other identifier: 455
• Study Type: interventional
• Target: 110
• Locations: 1 country
• Sites: 1

Brief Summary

The large body of evidence supports the chemotherapeutic potential of substances found in Olive Oil (OO), acting on different sides, such as inflammation, oxidative damage, and even epigenetic modulation. The consumption of OO should be suggested in a healthy diet instead of other types of oils. It looks worthy, to determine the effect of local application of Olive Oil in decreasing the friction between brackets and wires during orthodontic treatment.

Conditions

Orthodontic Tooth Movement

Keywords

Orthodontic tooth movement, olive oil

Outcome Measures

Primary Outcomes (1)

• The duration of orthodontic teeth aligning using Little irregualrity index

  To detect the effect of local usage of Olive Oil on orthodontic brackets during the alignment phase of orthodontic treatment in changing the Little's irregularity in- dex.

  4 months

Secondary Outcomes (1)

• orthodontic wire surface roughness changes

  one month

Study Arms (2)

Placebo

NO INTERVENTION

controlling group who will receive traditional orthodontic treatment.

Olive Oil

EXPERIMENTAL

experimental group who will receive the local application of Olive Oil five times daily after teeth brushing

Drug: Olive Oil Topical Oil

Interventions

Olive Oil Topical Oil DRUG

the effect of olive oil local application in decreasing orthodontic alighment phase

Also known as: olive oil

Olive Oil

Eligibility Criteria

• Age: 15 Years - 20 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64)

You may qualify if:

• The age of patients ranges from 15-20 years old.
• Mild to moderate dental irregularity requiring non-extraction treatment.
• Presence of all the permanent teeth at least up to the first molars.
• Good oral hygiene, and periodontal health.

You may not qualify if:

• Patients require orthognathic surgery to correct skeletal discrepancies.
• patients who are taking medications, like NSAIDs or other anti-inflammatory drugs.
• cleft lip or palate patients.
• patients with hypodontia, or hyperdontia.

Sponsors & Collaborators

• Minia University: lead

Study Sites (1)

Ahmed Nasef

Minya, 61111, Egypt

RECRUITING

Related Publications (9)

• Ehsani S, Mandich MA, El-Bialy TH, Flores-Mir C. Frictional resistance in self-ligating orthodontic brackets and conventionally ligated brackets. A systematic review. Angle Orthod. 2009 May;79(3):592-601. doi: 10.2319/060208-288.1.

  PMID: 19413397 RESULT

• Chimenti C, Franchi L, Di Giuseppe MG, Lucci M. Friction of orthodontic elastomeric ligatures with different dimensions. Angle Orthod. 2005 May;75(3):421-5. doi: 10.1043/0003-3219(2005)75[421:FOOELW]2.0.CO;2.

  PMID: 15898384 RESULT

• Carrion-Vilches FJ, Bermudez MD, Fructuoso P. Static and kinetic friction force and surface roughness of different archwire-bracket sliding contacts. Dent Mater J. 2015;34(5):648-53. doi: 10.4012/dmj.2014-295.

  PMID: 26438988 RESULT

• Matarese G, Nucera R, Militi A, Mazza M, Portelli M, Festa F, Cordasco G. Evaluation of frictional forces during dental alignment: an experimental model with 3 nonleveled brackets. Am J Orthod Dentofacial Orthop. 2008 May;133(5):708-15. doi: 10.1016/j.ajodo.2006.06.021.

  PMID: 18456144 RESULT

• Yanase Y, Ioi H, Nishioka M, Takahashi I. Effects of sliding velocity on friction: an in vitro study at extremely low sliding velocity approximating orthodontic tooth movement. Angle Orthod. 2014 May;84(3):451-8. doi: 10.2319/060513-427.1. Epub 2013 Oct 25.

  PMID: 24160997 RESULT

• Gorzynik-Debicka M, Przychodzen P, Cappello F, Kuban-Jankowska A, Marino Gammazza A, Knap N, Wozniak M, Gorska-Ponikowska M. Potential Health Benefits of Olive Oil and Plant Polyphenols. Int J Mol Sci. 2018 Feb 28;19(3):686. doi: 10.3390/ijms19030686.

  PMID: 29495598 RESULT

• Gotsis E, Anagnostis P, Mariolis A, Vlachou A, Katsiki N, Karagiannis A. Health benefits of the Mediterranean Diet: an update of research over the last 5 years. Angiology. 2015 Apr;66(4):304-18. doi: 10.1177/0003319714532169. Epub 2014 Apr 27.

  PMID: 24778424 RESULT

• Curto A, Albaladejo A, Montero J, Alvarado A. Influence of a Lubricating Gel (Orthospeed(R)) on Pain and Oral Health-Related Quality of Life in Orthodontic Patients during Initial Therapy with Conventional and Low-Friction Brackets: A Prospective Randomized Clinical Trial. J Clin Med. 2020 May 14;9(5):1474. doi: 10.3390/jcm9051474.

  PMID: 32423007 RESULT

• Little RM. The irregularity index: a quantitative score of mandibular anterior alignment. Am J Orthod. 1975 Nov;68(5):554-63. doi: 10.1016/0002-9416(75)90086-x.

  PMID: 1059332 RESULT

MeSH Terms

Interventions

Olive Oil

Intervention Hierarchy (Ancestors)

Dietary Fats, Unsaturated; Dietary Fats; Fats; Lipids; Fats, Unsaturated; Plant Oils; Oils; Food; Diet, Food, and Nutrition; Physiological Phenomena; Food and Beverages

Study Officials

• Ahmed Nasef, lecturer

  lecturer of orthodontics, Minia University

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Ahmed Nasef, lecturer

CONTACT

002-01003383457; a.nasef_ortho@hotmail.com

Asmaa Mahmoud, lecturer

CONTACT

002-01002966412; dentistasmaa_biology@hotmail.com

Study Design

• Study Type: interventional
• Phase: phase 1
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Lecturer of Orthodontics, Faculty of Dentistry, Minia University, Egypt

Study Record Dates

• First Submitted: November 15, 2020
• First Posted: September 10, 2021
• Study Start: January 1, 2020
• Primary Completion: March 30, 2022
• Study Completion: May 1, 2022
• Last Updated: September 10, 2021

Record last verified: 2021-09

Data Sharing

• IPD Sharing: Will not share

Locations

EG (1)