NCT07792603|Recruiting
Daily Upgrade Trial
TONE UP: Daily Upgrade Trial: Tone, Oxygenation, Neuromood, Energy - Upgrade Evaluation
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TONE UP: Daily Upgrade Trial: Tone, Oxygenation, Neuromood, Energy - Upgrade Evaluation
Sponsor study identifier
interventional
44
1 country
1
Study Start
August 31, 2026
Actual (reported)Primary Completion
April 2027
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Study Completion
April 2027
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
This study evaluates the acute and chronic effects of an essential amino acid supplement (Daily Upgrade EAA+) on metabolomics, amino acid kinetics, metabolic rate, body composition in active adult women. The study consists of an acute randomized double-blind crossover phase comparing EAA+, whey protein isolate, and placebo before high-intensity interval training (HIIT), and a chronic randomized double-blind parallel-arm phase evaluating 3 weeks of EAA+ or placebo supplementation combined with twice-weekly HIIT.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
April 2027
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
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Some registry-reported names shown below are not yet linked in this graph.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
August 25, 2026
Actual (reported)August 28, 2026
Actual (reported)August 31, 2026
Actual (reported)April 2027
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
April 2027
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Essential Amino Acid Kinetics
Area under the curve for metabolomic responses
Baseline, 30, 60, and 90 minutes following supplementation during acute visits.
Substrate Oxidation
Respiratory exchange ratio (RER)
Before (0 min) and after (30, 60, 90 min) one session of high intensity interval training
Lean Body Mass
Baseline and week 4
Muscle size
Baseline week 4
Fluid Kinetics
Baseline, week 1, week 2, week 3, week 4
Muscle Oxygen Capacity
Baseline and week 4
Mood
Baseline, week 4
Skin
Baseline, week 4
Essential amino acids, creatine, magnesium, electrolytes consumed once (daily) with 8-12 oz of water.
Non-caloric placebo consumed once (daily) with 8-12 oz of water
Daily supplementation of essential amino acids
Daily supplementation with non-caloric placebo
Applied Physiology Laboratory
Chapel Hill, North Carolina, 27599, United States
Abbie Smith-Ryan, PhD
University of North Carolina, Chapel Hill
First Submitted
August 25, 2026
First Posted
August 28, 2026
Study Start
Exercise Intensity, Metabolic Rate and Insulin Sensitivity
1 serving whey protein isolate mixed with 8-12 oz of water
Twice weekly high intensity interval training for 3 weeks
No exercise
Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.
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August 31, 2026
Actual (reported)Primary Completion
April 2027
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Study Completion
April 2027
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Last Updated
September 3, 2026
Record last verified: 2026-08
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Source: ClinicalTrials.gov.
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