Alvogyl Versus Platelet-Rich Fibrin for Healing of Alveolar Osteitis

NCT07790653 | Completed

• 1 other identifier: MANNAL-ALVO-PRF-2026
• Study Type: interventional
• Target: 102
• Locations: 1 country
• Sites: 1

Brief Summary

Alveolar osteitis, commonly known as dry socket, is a painful complication that can occur after tooth extraction, particularly following removal of a mandibular third molar. It occurs when normal healing of the extraction socket is disrupted and is commonly associated with significant pain and delayed healing. Alvogyl is a commonly used dressing for managing dry socket and can provide rapid pain relief. Platelet-rich fibrin (PRF) is a preparation made from the patient's own blood that contains platelets, white blood cells, fibrin, and growth factors that may promote tissue repair and wound healing. This randomized controlled clinical trial will compare Alvogyl and platelet-rich fibrin in patients diagnosed with alveolar osteitis following third molar extraction. A total of 102 eligible adult participants will be randomly assigned to receive either Alvogyl or PRF as treatment for the affected extraction socket. The study will compare the healing outcomes of the two treatments by assessing pain intensity and the number of exposed socket walls during follow-up. Pain will be assessed using a visual analogue scale, while socket healing will be evaluated clinically by recording the number of exposed socket walls. The study aims to determine whether PRF provides better healing outcomes than conventional Alvogyl treatment for alveolar osteitis. The findings may help clinicians select an effective treatment approach for reducing pain and promoting healing in patients with dry socket.

Conditions

Alveolar Osteitis

Keywords

Alveolar Osteitis; Dry socket; Platelet-rich fibrin; Extraction socket; Third molar extraction

Outcome Measures

Primary Outcomes (2)

• Mean Pain Score

  Pain intensity will be assessed using a 0-10 Visual Analogue Scale (VAS), where 0 indicates no pain and 10 indicates the worst possible pain. The mean VAS pain score on postoperative Days 1 and 3 will be compared between the Alvogyl and platelet-rich fibrin groups.

  Postoperative Day 1 and 3

• Mean Number of Socket Wall Exposures

  The number of exposed socket walls will be assessed by clinical examination on postoperative Days 1 and 3. The mean number of socket wall exposures will be compared between the Alvogyl and platelet-rich fibrin groups to evaluate the healing status of the extraction socket.

  Days 1 and 3

Study Arms (2)

Alvogyl Group

ACTIVE COMPARATOR

Participants diagnosed with alveolar osteitis will receive standard socket irrigation with warm saline and debridement, followed by placement of Alvogyl into the extraction socket. The socket will be secured with 3-0 silk sutures using a figure-of-eight technique. No topical or systemic antibiotics will be administered.

Procedure: Alvogyl Dressing

Platelet-Rich Fibrin Group

EXPERIMENTAL

Participants diagnosed with alveolar osteitis will receive autologous platelet-rich fibrin (PRF). Ten millilitres of venous blood will be collected and centrifuged without anticoagulant to prepare a PRF membrane. Following standard socket irrigation and debridement with warm saline, the PRF membrane will be placed into the extraction socket and secured with 3-0 silk sutures using a figure-of-eight technique. No topical or systemic antibiotics will be administered.

Biological: Platelet-Rich Fibrin (PRF)

Interventions

Alvogyl Dressing PROCEDURE

Alvogyl will be used as an intra-alveolar dressing for the treatment of alveolar osteitis. Following gentle irrigation of the extraction socket with warm saline and debridement, Alvogyl will be placed into the socket. The socket will then be secured with 3-0 silk sutures using a figure-of-eight technique to maintain the dressing in position. No topical or systemic antibiotics will be administered.

Alvogyl Group

Platelet-Rich Fibrin (PRF) BIOLOGICAL

Autologous platelet-rich fibrin will be prepared from 10 mL of the participant's venous blood collected into two 5-mL tubes without anticoagulant. The blood will be centrifuged at 3000 rpm for 10 minutes. The resulting PRF layer will be separated and compressed between sterile saline-moistened gauze to form a membrane. Following standard socket irrigation and debridement with warm saline, the PRF membrane will be placed into the extraction socket and secured with 3-0 silk sutures using a figure-of-eight technique. No topical or systemic antibiotics will be administered.

Platelet-Rich Fibrin Group

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Adults aged 18 years or older.
• Participants of either sex.
• Patients presenting with alveolar osteitis following third molar extraction, diagnosed according to the study's operational definition.
• Patients willing to participate in the study and provide informed consent.
• Patients willing and able to attend the scheduled postoperative follow-up assessments.

You may not qualify if:

• Patients with a smoking habit.
• Patients with a history of bleeding disorders.
• Patients unwilling or unable to attend the required follow-up sessions.
• Patients with a history of hypertension, diabetes mellitus, liver disease, or renal disease.
• Pregnant or breastfeeding individuals.
• Patients using medications that may affect healing or study outcomes, including bisphosphonates, systemic steroids, or antidepressants.

Sponsors & Collaborators

• CMH Lahore Medical College and Institute of Dentistry: lead

Study Sites (1)

CMH Lahore

Lahore, Pakistan

Location

MeSH Terms

Conditions

Dry Socket

Condition Hierarchy (Ancestors)

Mouth Diseases; Stomatognathic Diseases

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: QUADRUPLE
• Who Masked: PARTICIPANT, CARE PROVIDER, INVESTIGATOR, OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Doctor

Study Record Dates

• First Submitted: August 24, 2026
• First Posted: August 27, 2026
• Study Start: February 10, 2026
• Primary Completion: August 1, 2026
• Study Completion: August 15, 2026
• Last Updated: August 27, 2026

Record last verified: 2026-08

Data Sharing

• IPD Sharing: Will not share

Locations

PA (1)