NCT07139340

Brief Summary

The study aimed to investigate the effectiveness of Hyaluronic Acid gel on decreasing the incidence of alveolar osteitis after mandibular third molar extraction.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
64

participants targeted

Target at P50-P75 for not_applicable

Timeline
Completed

Started Aug 2016

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

August 30, 2016

Completed
10 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

July 1, 2017

Completed
1 month until next milestone

Study Completion

Last participant's last visit for all outcomes

August 1, 2017

Completed
8 years until next milestone

First Submitted

Initial submission to the registry

August 17, 2025

Completed
7 days until next milestone

First Posted

Study publicly available on registry

August 24, 2025

Completed
Last Updated

August 24, 2025

Status Verified

August 1, 2016

Enrollment Period

10 months

First QC Date

August 17, 2025

Last Update Submit

August 17, 2025

Conditions

Alveolar Osteitis

Outcome Measures

Primary Outcomes (1)

  • Occurence of Alveolar Osteitis (AO)

    Presence of empty extraction socket without healing clot indicates AO (measured by clinical inspection; Presence of AO=1, Absence of AO=0)

    7 postoperative days

Secondary Outcomes (1)

  • Postoperative pain

    7 postoperative days

Study Arms (2)

Study group (HA gel)

ACTIVE COMPARATOR

HA gel was placed intrasocket after extraction

Other: HA gel

Control group (No HA gel)

NO INTERVENTION

Nothing was placed intrasocket after extraction

Interventions

HA gelOTHER

Hyaluronic Acid gel 0.8% 1 mL

Also known as: Hyaluronic Acid gel
Study group (HA gel)

Eligibility Criteria

Age18 Years - 33 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64)

You may qualify if:

  • Healthy patients (ASA=1)
  • Patients need extraction of mandibular third molar
  • Patients can attend recalls

You may not qualify if:

  • Smoking patients
  • Patients taking oral contraceptive pills
  • Bad oral hygiene

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Delta university for science and technology

Gamasa, Dakahlia Governorate, 7731168, Egypt

Location

MeSH Terms

Conditions

Dry Socket

Condition Hierarchy (Ancestors)

Mouth DiseasesStomatognathic Diseases

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
PREVENTION
Intervention Model
PARALLEL
Model Details: Control group (No HA gel), and study group (HA gel)
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

August 17, 2025

First Posted

August 24, 2025

Study Start

August 30, 2016

Primary Completion

July 1, 2017

Study Completion

August 1, 2017

Last Updated

August 24, 2025

Record last verified: 2016-08

Data Sharing

IPD Sharing
Will not share

Locations

EG(1)