Comparison Between Two Blocks in Analgesia After Knee Arthroplasty

NCT07046377 | Active Not Recruiting DMC

• 1 other identifier: FMASU MS64/2025
• Study Type: interventional
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

Comparative Study between Adductor canal block combined with infiltration OF The interspace between popliteal artery and the capsule of the knee block versus genicular nerves Block combined with IPACK in Postoperative analgesia after knee replacement surgery

Conditions

Post Operative Pain

Outcome Measures

Primary Outcomes (1)

• 1- Comparing both groups regarding the time needed ( in hours) for the first call rescue analgesia post operatively.

  Total knee replacement (TKR) is a well-known popular surgical procedure for knee diseases, including end-stage knee osteoarthritis that causes severe postoperative pain and prolonged immobility. Acute pain control can be provided with multimodal analgesia, including non-steroidal anti-inflammatory drugs (NSAIDs) and opioids. However, NSAIDs cause many side effects as peptic ulcer and gastritis, also opioids have gastrointestinal side effects as constipation, nausea and vomiting as well as respiratory depression. Regional analgesia has been used as another modality to provide sufficient perioperative pain relief with minimal opioid consumption to avoid it's adverse effects peripheral nerve blocks (PNBs) is a common practice in orthopedic surgery. PNBs provide excellent pain management after TKA, promote early mobilization, and reduce the consumption of opioids, the incidence of opioid-related adverse effects, and the hospital stay

  5 minutes after ending of operation

Study Arms (2)

Group 1

ACTIVE COMPARATOR

Adductor canal block + IPACK group

Procedure: ACB - IPACK

Group 2

ACTIVE COMPARATOR

Genicular nerves block + IPACK block.

Procedure: GNB - IPACK

Interventions

ACB - IPACK PROCEDURE

will receive spinal anesthesia and ultrasound-guided Adductor canal nerve block, as well as infiltration of the space between the popliteal artery and the capsule of the posterior knee (IPACK) block.

Group 1

GNB - IPACK PROCEDURE

will recieve spinal anesthesia and US guided Genicular nerves block and IPACK block.

Group 2

Eligibility Criteria

• Age: 30 Years - 85 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Age 30-85 years.
• Both sexes.
• American Society of Anesthesiologists (ASA) Physical Status Class I to III.
• Patients scheduled for unilateral TKA under spinal anesthesia.

You may not qualify if:

• Patient's refusal.
• American Society of Anesthesiologists (ASA) Physical Status Class above III.
• local infection.
• History of allergy to the medications used in the study. 5. Psychiatric disorder.

Sponsors & Collaborators

• Ain Shams University: lead

Study Sites (1)

Ain shams university

Cairo, Cairo Governorate, Egypt

Location

MeSH Terms

Conditions

Pain, Postoperative

Condition Hierarchy (Ancestors)

Postoperative Complications; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Pain; Neurologic Manifestations; Signs and Symptoms

Study Officials

• Mai Ma Abd ElAziz, MBBCH

  Ain Shams University

  PRINCIPAL INVESTIGATOR

• Mai Ma Abd ElAziz Ibrahim, MBBCH

  Ain Shams University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: OTHER
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: May 6, 2025
• First Posted: July 1, 2025
• Study Start: January 29, 2025
• Primary Completion: July 29, 2025
• Study Completion: July 29, 2025
• Last Updated: July 1, 2025

Record last verified: 2025-05

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL, SAP, ICF
• Time Frame: Before 1/2026
• Access Criteria: Free

Locations

EG (1)