Preoperative Pain Neuroscience Education in Patients Undergoing CABG

NCT07783750 | Completed

• 2 other identifiers: HRU-PNE-CABG-2025-01HRÜ/25.11.28
• Study Type: interventional
• Target: 76
• Locations: 1 country
• Sites: 1

Brief Summary

This randomized controlled trial evaluated the effects of a single preoperative pain neuroscience education (PNE) session on postoperative pain-related outcomes in patients undergoing elective coronary artery bypass grafting (CABG). Participants were randomly allocated to either a PNE group, which received a structured preoperative PNE session in addition to routine preoperative care, or a control group, which received routine preoperative information and care. Outcomes included pain intensity, pain catastrophizing, pain vigilance and awareness, and pressure pain threshold. Assessments were conducted preoperatively and at 24 hours, 1 month, and 3 months after surgery.

Conditions

Coronary Artery Bypass Grafting; Postoperative Pain

Keywords

Pain Neuroscience Education; Coronary Artery Bypass Grafting; CABG; Postoperative Pain; Chronic Postoperative Pain; Pain Catastrophizing; Pain Vigilance; Pressure Pain Threshold

Outcome Measures

Primary Outcomes (1)

• Cough-Evoked Surgical-Site Pain Intensity at 3 Months

  Cough-evoked pain intensity at the surgical site was assessed using a 0-10 pain rating scale, with higher scores indicating greater pain intensity.

  3 months after surgery

Secondary Outcomes (6)

• Cough-Evoked Surgical-Site Pain Intensity

  24 hours and 1 month after surgery

• Pain Catastrophizing

  Baseline, 1 month, and 3 months after surgery

• Pain Vigilance and Awareness

  Baseline, 1 month, and 3 months after surgery

• Local Pressure Pain Threshold

  Baseline, 1 month, and 3 months after surgery

• Remote Pressure Pain Threshold

  Baseline, 1 month, and 3 months after surgery

Study Arms (2)

Preoperative Pain Neuroscience Education

EXPERIMENTAL

Participants received a structured preoperative pain neuroscience education (PNE) session in addition to routine preoperative care. The education addressed the neurophysiology of pain, the role of the nervous system and brain in pain perception, factors influencing pain experiences, common misconceptions about pain, and strategies for understanding and coping with postoperative pain.

Behavioral: Pain Neuroscience Education

Routine Preoperative Care

NO INTERVENTION

Participants received routine preoperative information and standard care provided to patients undergoing elective coronary artery bypass grafting (CABG). No structured pain neuroscience education was provided to this group.

Interventions

Pain Neuroscience Education BEHAVIORAL

Participants received a structured pain neuroscience education session preoperatively in addition to routine preoperative care. The education addressed the neurophysiology of pain, the role of the nervous system and brain in pain perception, factors influencing the pain experience, common pain-related misconceptions, and strategies for understanding and coping with postoperative pain.

Preoperative Pain Neuroscience Education

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Adults aged 18 years or older Scheduled for elective coronary artery bypass grafting (CABG) through median sternotomy Able to understand and communicate sufficiently to participate in the education and outcome assessments Provided informed consent to participate in the study

You may not qualify if:

• Emergency CABG surgery Concomitant cardiac surgical procedures other than CABG Inability to understand or participate in the pain neuroscience education session Cognitive or communication impairment preventing completion of study assessments Postoperative clinical conditions preventing participation in the planned assessments

Sponsors & Collaborators

• İsmail Palalı: lead

Study Sites (1)

Harran University Faculty of Medicine Training and Research Hospital

Sanliurfa, Şanlıurfa, 63000, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Pain, Postoperative

Condition Hierarchy (Ancestors)

Postoperative Complications; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Pain; Neurologic Manifestations; Signs and Symptoms

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: PhD,Assistant Professor

Model Details: Participants undergoing elective CABG were randomly allocated to either a preoperative pain neuroscience education group or a control group receiving routine preoperative care.

Study Record Dates

• First Submitted: August 21, 2026
• First Posted: August 25, 2026
• Study Start: June 23, 2025
• Primary Completion: August 3, 2026
• Study Completion: August 4, 2026
• Last Updated: August 27, 2026

Record last verified: 2026-08

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)