Serratus Anterior Plan Block (SAP) and Pectoralis Blocks (PECS I-II) After Open Heart Surgery

NCT06793436 | Completed

• 1 other identifier: 17/05/2023
• Study Type: interventional
• Target: 243
• Locations: 1 country
• Sites: 1

Brief Summary

It was aimed to examine the effects of anterior chest wall blocks (PECS and SAP) performed for postoperative analgesia on pain scores assessed using the Visual Analog Scale (VAS), opioid consumption, duration of mechanical ventilation, time to first mobilization, ICU length of stay, postoperative nausea and vomiting (PONV), and block-related complications in adult patients undergoing coronary artery bypass grafting (CABG).

Conditions

Postoperative Pain; Coronary Artery Bypass Grafting

Keywords

Serratus Anterior Plane Block; PECS II Block; Regional Anesthesia; Opioid-Sparing; Cardiac Surgery

Outcome Measures

Primary Outcomes (1)

• Postoperative pain intensity assessed using the Visual Analog Scale (VAS)

  Pain intensity will be assessed using the Visual Analog Scale (VAS). The VAS is a 10-centimeter scale where 0 cm = "no pain" and 10 cm = "worst imaginable pain"; higher scores indicate worse pain intensity. Assessments will be performed at 4, 8, 12, and 24 hours after extubation.

  4, 8, 12, and 24 hours after extubation

Secondary Outcomes (5)

• Postoperative nausea and vomiting (PONV) and block-related complications

  Within 24 hours after surgery

• Exploratory ICU length of stay

  From ICU admission until ICU discharge, assessed up to 30 days

• Exploratory time to first mobilization

  From ICU admission until first mobilization, assessed up to 7 days

• Exploratory mechanical ventilation duration

  From ICU admission until successful extubation, assessed up to 7 days

• Total opioid consumption within the first 24 postoperative hours

  Cumulative opioid consumption assessed during the first 24 postoperative hours

Study Arms (3)

SAP Block Group

EXPERIMENTAL

Patients undergoing coronary artery bypass grafting received an ultrasound-guided serratus anterior plane (SAP) block with 30 mL of 0.25% bupivacaine administered to the fascial plane.

Procedure: Serratus Anterior Plane Block

PECS II Block Group

ACTIVE COMPARATOR

Patients undergoing coronary artery bypass grafting received an ultrasound-guided PECS II block using a two-injection technique with a total of 30 mL of 0.25% bupivacaine.

Procedure: PECS II Block

Group C

NO INTERVENTION

Patients receiving standard systemic analgesia without regional block. All patients received intravenous paracetamol and rescue opioid analgesia as required according to institutional protocol.

Interventions

Serratus Anterior Plane Block PROCEDURE

Ultrasound-guided serratus anterior plane (SAP) block performed with 30 mL of 0.25% bupivacaine.

SAP Block Group

PECS II Block PROCEDURE

Ultrasound-guided PECS II block performed using a two-injection technique with a total of 30 mL of 0.25% bupivacaine.

PECS II Block Group

Eligibility Criteria

• Age: 20 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may not qualify if:

• Refusal to participate
• Pregnancy
• Presence of bleeding diathesis
• Severe hepatic or renal failure

Sponsors & Collaborators

• Yuzuncu Yil University: lead

Study Sites (1)

Van Yuzuncu Yil University Faculty of Medicine Department of anesthesiology and reanimation

Van, Tuşba, 65080, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Pain, Postoperative

Condition Hierarchy (Ancestors)

Postoperative Complications; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Pain; Neurologic Manifestations; Signs and Symptoms

Study Officials

• School of Mdicine Department of Anesthesiology and Reanimation

  Yuzuncu Yil University

  STUDY CHAIR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Masking Details: Postoperative outcome assessors were blinded to group allocation.
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor

Model Details: Prospective randomized controlled trial

Study Record Dates

• First Submitted: May 17, 2023
• First Posted: January 27, 2025
• Study Start: December 5, 2022
• Primary Completion: December 5, 2023
• Study Completion: January 31, 2024
• Last Updated: May 18, 2026

Record last verified: 2026-05

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)