Comparison of Transversus Abdominis Plane and Erector Spinae Plane Blocks for Pain Control After Renal Laparoscopy

NCT07781930 | Recruiting DMC

• 1 other identifier: MS-595-2025
• Study Type: interventional
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this study is to compare the analgesic efficacy of ultrasound-guided transversus abdominis plane (TAP) block versus erector spinae plane block (ESPB) in adult patients undergoing laparoscopic renal surgeries. Forty adults (18-60 years, ASA I-II) will be randomly assigned to receive either TAP or ESPB after induction of general anesthesia. Postoperative pain will be assessed using the Visual Analogue Scale (VAS) and total fentanyl consumption over 24 hours. Secondary outcomes include time to first analgesic request, hemodynamic parameters, patient satisfaction, and incidence of complications. The study will be conducted at Cairo University Hospitals following ethical approval, with all patients providing written informed consent.

Conditions

Postoperative Pain, Acute

Keywords

TAP Block; ESP Block

Outcome Measures

Primary Outcomes (1)

• Total fentanyl consumption.

  Total fentanyl consumption in the first 24 hours (μg-microgram) postoperative.

  24 hours.

Secondary Outcomes (7)

• Time to first rescue analgesia.

  24 hours postoperatively.

• Postoperative Pain scores.

  At Post Anesthesia Care Unit (PACU) and 2,4,6,12,18,24 hours Postoperatively.

• Hemodynamic Parameter Heart rate

  At PACU and 1,2,4,6,12,24 hours postoperatively.

• Hemodynamic Parameter

  At PACU and 1,2,4,6,12,24 hours postoperatively.

• Hemodynamic Parameter oxygen saturation

  At PACU and 1,2,4,6,12,24 hours postoperatively.

Study Arms (2)

TAP Block group

EXPERIMENTAL

TAP block will be done under ultrasound-guidance with linear multi-frequency 6-13 MHz transducer probe and 21 G (0.514mm) needle inserted in-plane from medial to lateral, advanced through the fascial layers until the tip reaches the fascial plane between the internal oblique and the transversus abdominis muscle. After negative aspiration, 20 ml of 0.25% bupivacaine will be injected. Correct spread will be confirmed by separation of the fascial plane under ultrasound guidance. TAP block will be applied bilaterally.

Procedure: TAP Block

ESP Block group

EXPERIMENTAL

a high-frequency linear ultrasound probe will be placed in a longitudinal parasagittal orientation over the transverse process at the T8-T9 level. A 21G needle will be advanced in-plane to reach the fascial plane deep to the erector spinae muscle and superficial to the transverse process. After negative aspiration, 20 ml of 0.25% bupivacaine (Sunnypivacaine®, Sunny pharmaceuticals, Egypt) will be injected incrementally to ensure correct spread of local anesthetic in the ESP plane.

Procedure: TAP Block

Interventions

TAP Block PROCEDURE

a bilateral ultrasound guided TAP block performed by injecting 20 ml of 0.25% bupivacaine into the TAP space after negative aspiration. a bilateral ultrasound guided ESP block performed by injecting 20 ml of 0.25% bupivacaine into the ESP space after negative aspiration.

Also known as: ESP Block

ESP Block group; TAP Block group

Eligibility Criteria

• Age: 18 Years - 40 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• Age from 18 to 40 years old.
• Both sexes.
• American Society of Anesthesiology (ASA) physical status I, II.
• Scheduled for laparoscopic renal surgeries under general anesthesia

You may not qualify if:

• Parent's refusal.
• Coagulation disorders.
• History of allergy to local anesthetics.
• Infection or redness at the injection site.
• History of renal and/or hepatic insufficiency.
• Preexisting cardiac dysfunction.

Sponsors & Collaborators

• Cairo University: lead

Study Sites (1)

Kasr Al-Ainy hospital

Cairo, 11562, Egypt

RECRUITING

MeSH Terms

Conditions

Pain, Postoperative

Condition Hierarchy (Ancestors)

Postoperative Complications; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Pain; Neurologic Manifestations; Signs and Symptoms

Study Officials

• Hala ElSabbagh, M.D.

  Cairo University

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Hala ElSabbagh, M.D.

CONTACT

01005207896; halaelsabbagh@gmail.com

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: lecturer of Anesthesiology

Study Record Dates

• First Submitted: June 30, 2026
• First Posted: August 24, 2026
• Study Start: January 5, 2026
• Primary Completion: August 1, 2026
• Study Completion: August 1, 2026
• Last Updated: August 24, 2026

Record last verified: 2026-08

Data Sharing

• IPD Sharing: Will not share

Locations

EG (1)