Erector Spinae Plane Block Versus Iliohypogastric/Ilioinguinal Nerve Block for Post-Hysterctomy Pain Relief

NCT07113600 | Not Yet Recruiting DMC

• 1 other identifier: N-119_2023/MSc
• Study Type: interventional
• Target: 60
• Locations: 0 countries
• Sites: N/A

Brief Summary

The goal of this clinical trial is to compare the degree of pain relief between two techniques of regional anesthesia given to ladies undergoing hysterectomy under general anesthesia. One group of patients will have a local anesthetic injected between muscle layers in their back (ultrasound guided Erector Spinae plane Block). The other group will have a local anesthetic injected around specific nerves in their abdomen (ultrasound guided Ilio-hypogastric / ilio-inguinal nerve block ). Researchers will compare the duration of postoperative pain relief , the degree of pain relief and any possible side effects of either techniques.

Conditions

Postoperative Pain, Acute

Keywords

Humans; Female; Anesthesia, Conduction; Ultrasonography; Nerve Block; Pain, Postoperative; Ultrasonography, Interventional

Outcome Measures

Primary Outcomes (1)

• The time to first call for analgesia.

  The period of time starting from extubation until the patient asks for analgesia in hours.

  The first 12 postoperative hours

Secondary Outcomes (2)

• postoperative pain score

  VAS was assessed at 0, 2, 6, and 12 hours postoperatively.

• intraoperative hemodynamic changes

  Operative time

Other Outcomes (1)

• Total post-operative opioid consumption

  The first 12 postoperative hours

Study Arms (2)

ESPB

ACTIVE COMPARATOR

Patients will receive bilateral Erector Spinae Plane block using 20ml bupivacaine 0.25% on each side.

Other: Nerve Block

Ilioinguinal/iliohypogastric

ACTIVE COMPARATOR

Patients will receive bilateral Iliohypogastric and Ilioinguinal nerve block using 20ml bupivacaine 0.25% on each side.

Other: Nerve Block

Interventions

Nerve Block OTHER

Ilioinguinal/ Iliohypogastric nerve block: In the supine position, the ultrasound probe probe is positioned in a transverse manner, superior to the anterior superior iliac spine. The three anterior abdominal muscle layers are identified, and the two nerves are identified in the abdominal neurovascular plane. A echogenicneedle is inserted in a medial-to-lateral direction. After negative aspiration, 5 ml saline is injected to ensure correct needle tip position then 20 ml of bupivacaine 0.25% is injected gradually close to the nerves. Erector spinae plane block: In a lateral position, the erector spinae is visualized about 3 cm lateral to T7-T9 spinous processes on the target side. A echogenic needle (50 mm/22 gauge) is advanced in a cephalad to caudad direction until the tip reaches the plane deep to the erector spinae muscle immediately lateral to the transverse process. A 20 ml bupivacaine 0.25% is injected gradually into this plane.

ESPB; Ilioinguinal/iliohypogastric

Eligibility Criteria

• Age: 35 Years+
• Sex: female
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Adult female patients above the age of 35 years.
• American Society of Anesthesiologists (ASA) physical status I-II.

You may not qualify if:

• Patient refusal.
• History of allergy or intolerance to study medications.
• Chronic opioid use (\>3 months).
• Severe renal or hepatic impairment.
• Patients with coagulopathy disorders.
• Infection at injection sites.

Sponsors & Collaborators

• Kasr El Aini Hospital: lead

MeSH Terms

Conditions

Pain, Postoperative

Interventions

Nerve Block

Condition Hierarchy (Ancestors)

Postoperative Complications; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Pain; Neurologic Manifestations; Signs and Symptoms

Intervention Hierarchy (Ancestors)

Anesthesia, Conduction; Anesthesia; Anesthesia and Analgesia; Denervation; Neurosurgical Procedures; Surgical Procedures, Operative

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Masking Details: Both blocks will be performed after induction of general anesthesia
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor Of anesthesia

Model Details: Patients will be randomly allocated with a 1:1 allocation ratio into two groups in a parallel manner: * Group A(n=29): Patients will receive bilateral ESP block using 20 ml bupivacaine 0.25% on each side. * Group B(n=29): Patients will receive bilateral Iliohypogastric and Ilioinguinal nerve block using 20 ml bupivacaine 0.25% on each side.

Study Record Dates

• First Submitted: July 22, 2025
• First Posted: August 11, 2025
• Study Start: August 1, 2025
• Primary Completion: October 1, 2025
• Study Completion: October 1, 2025
• Last Updated: August 11, 2025

Record last verified: 2025-08