Modified Versus Conventional Serratus Anterior Plane Block

NCT05661253 | Unknown

• 1 other identifier: ZU-IRB # 10061
• Study Type: interventional
• Target: 99
• Locations: 1 country
• Sites: 1

Brief Summary

comparing preemptive analgesia with ultrasound guided modified serratus anterior plane block versus ultrasound guided serratus anterior plane block

Conditions

Postoperative Pain, Acute

Outcome Measures

Primary Outcomes (1)

• tramadol consumption

  The amount of tramadol consumption at 24

  at 24 hours postoperative

Secondary Outcomes (3)

• Time of performance

  from ultrasound probe positioning till the end of the block procedure

• Time to first dose of rescue analgesia

  during the first postoperative 24 hours

• Patient satisfaction

  at 24 hous post operative

Study Arms (3)

Control group

NO INTERVENTION

will take general anesthesia without nerve block

SAP block group

ACTIVE COMPARATOR

After sterilization of the skin and draping, the high frequency linear probe of Sonosite M Turbo ultrasonography (FUJIFIM sonosite, Inc., Bothell, WA, USA) will be placed at the level of the midclavicular line in a sagittal plane. The second rib will be recognized at the axillary artery. The probe will be moved downward to count the ribs until the level of the fifth rib in the mid-axillary line. At this time, the latissimus dorsi muscle (lying superficial) and the serratus anterior muscle (lying deep) will be clearly visualized under ultrasound . Next, A 22-gauge, 80 mm needle (Stimuplex D, B-Braun, Germany) will be inserted in plane relative to the ultrasound probe between the latissimus dorsi and the serratus anterior muscle. After confirming negative aspiration of blood, 1 ml normal saline will be injected for hydro-dissection sign to verify the needle tip, then a volume of 25 ml 0.25% bupivacaine will be injected superficially to serratus anterior muscle. .

Drug: 25 ml of bupivacaine 0.25% via serratus anterior block

modified SAP block group

ACTIVE COMPARATOR

The patient will be placed in the lateral decubitus position according to the selected site of surgical intervention. After sterilization of the skin and draping, the high frequency linear probe of Sonosite M Turbo ultrasonography ( FUJIFIM sonosite, Inc., Bothell, WA, USA) will be placed horizontally midway between tip of the scapula and posterior axillary line to identify the view of latissimus dorsi(lying superficial) and serratus anterior muscle(lying deep) over either the sixth or seventh rib. A 22-gauge, 80 mm needle (Stimuplex D, B-Braun, Germany) will be inserted in plane relative to the ultrasound probe from posteromedial to anterolateral direction toward posterior axillary line till reaching the interfacial plane between latissimus dorsi and serratus anterior muscle . After confirming negative aspiration of blood, 1 ml normal saline will be injected for hydro-dissection sign to verify the needle tip, then a volume of 25 ml 0.25% bupivacaine will be injected .

Drug: 25 ml of bupivacaine 0.25% via modified serratus anterior palne block

Interventions

25 ml of bupivacaine 0.25% via serratus anterior block DRUG

patients will receive conventional serratus anterior plane block with a volume of 25 ml of bupivacaine 0.25% followed by induction of general anesthesia,

SAP block group

25 ml of bupivacaine 0.25% via modified serratus anterior palne block DRUG

patients will receive modified serratus anterior plane block with a volume of 25 ml of bupivacaine 0.25% followed by induction of general anesthesia.

modified SAP block group

Eligibility Criteria

• Age: 21 Years - 60 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Patient consent.
• both sex.
• Age: 21-70 years old.
• BMI: 18- 30 kg/m2
• ASA: I and II.
• Scheduled for elective unilateral Video-Assisted thoracoscopy under general anesthesia.

You may not qualify if:

• History of allergy to the local anesthesia agents used in this study,
• Skin lesion at needle insertion site,
• Those receiving anticoagulant therapy or having bleeding disorders
• Patients with history of chronic pain and taking analgesics,
• Patients with sepsis and Significant cardiac, liver or renal diseases
• Uncooperative patients or with psychiatric disorders.

Sponsors & Collaborators

• Zagazig University: lead

Study Sites (1)

Heba M Fathi

Zagazig, 44519, Egypt

RECRUITING

Related Publications (1)

• Abd Ellatif SE, Galal Eldin AM, Ali ES, Fathi HM. Ultrasound-guided modified versus conventional serratus anterior plane block as a preemptive analgesic for unilateral video-assisted thoracoscopic surgery. BMC Anesthesiol. 2025 Aug 29;25(1):435. doi: 10.1186/s12871-025-03314-5.

  PMID: 40883665 DERIVED

MeSH Terms

Conditions

Pain, Postoperative

Interventions

Bupivacaine

Condition Hierarchy (Ancestors)

Postoperative Complications; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Pain; Neurologic Manifestations; Signs and Symptoms

Intervention Hierarchy (Ancestors)

Anilides; Amides; Organic Chemicals; Aniline Compounds; Amines

Study Officials

• Heba M Fathi

  faculty of human medicine ,zagazig university

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Heba M Fathi

CONTACT

002-01000143938; heba_elgendi@yahoo.com

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: TRIPLE
• Who Masked: PARTICIPANT, CARE PROVIDER, OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER GOV
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: prof/Dr

Study Record Dates

• First Submitted: December 1, 2022
• First Posted: December 22, 2022
• Study Start: December 2, 2022
• Primary Completion: October 2, 2023
• Study Completion: October 30, 2023
• Last Updated: August 29, 2023

Record last verified: 2023-08

Data Sharing

• IPD Sharing: Will not share

Locations

EG (1)