Bicarbonate HD Study

NCT07779200 | Recruiting

• 2 other identifiers: RD2025-72366999
• Study Type: observational
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

The primary goal of this single centre observational study is to look at factors that affect serum bicarbonate levels in patients on maintenance dialysis. This will be done by collecting demographic information, relevant medical history, dialysis history, potential renal acid load from diet by recording different foods consumed over 2 days in a food diary and bicarbonate levels at 3 intervals, pre and post dialysis session 1 and pre dialysis session 2. Bicarbonate levels are of significant interest as an indicator of metabolic acidosis in CKD dialysis patients. This study will allow us to understand the efficacy of different dialysis modalities in controlling bicarbonate levels. It will also enable us to understand the idea of individualizing dialysis for patients in terms of not using a standard concentration of dialysate for all patient undergoing dialysis in this center.

Conditions

Metabolic Acidosis; CKD on Hemodialysis Patients

Outcome Measures

Primary Outcomes (1)

• Change in serum bicarbonate levels in patients on haemodialysis

  Serum bicarbonate concentration measured across two dialysis sessions (HD1 and HD2) measured as Pre HD1, Post HD2 and Pre HD2.

  3 months

Secondary Outcomes (3)

• Dietary Acid Load

  ~ 3 months

• Volume of Haemodiafiltration

  3 months

• Indicators of dialysis dose

  3 months

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The study population will consist of adult patients with End Stage Renal Disease (ESRD) receiving maintenance dialysis at the study centre.

You may qualify if:

• Age 18 years and above.
• Ability to give informed consent.
• End Stage Renal Disease established on maintenance dialysis for at least 3 months.
• Patients on dialysis 3 times a week

You may not qualify if:

• Inability to give informed consent
• Patients with acute kidney injury
• Patients with severe COPD

Sponsors & Collaborators

• East and North Hertfordshire NHS Trust: lead

Study Sites (1)

East and North Hertfordshire NHS Trust

Stevenage, Hertfordshire, SG1 4AB, United Kingdom

RECRUITING

MeSH Terms

Conditions

Acidosis

Condition Hierarchy (Ancestors)

Acid-Base Imbalance; Metabolic Diseases; Nutritional and Metabolic Diseases

Central Study Contacts

Enric Vilar

CONTACT

01438 284230; enric.vilar@nhs.net

Simran Sorathia

CONTACT

01438 284230; simran.sorathia@nhs.net

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER GOV
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: July 2, 2026
• First Posted: August 21, 2026
• Study Start: May 12, 2026
• Primary Completion: August 1, 2026
• Study Completion: August 1, 2026
• Last Updated: August 21, 2026

Record last verified: 2026-08

Locations

GB (1)