Respiratory Admittance by Oscillometry in Children

NCT07771608 | Not Yet Recruiting

• 1 other identifier: 2026PI185
• Study Type: observational
• Target: 144
• Locations: 0 countries
• Sites: N/A

Brief Summary

Oscillometry is a pulmonary function testing technique suited for children because it does not require specific respiratory maneuvers like spirometry. Oscillometry provides a measure of respiratory impedance (Zrs) that is underestimated when the oscillatory signal is applied at the subject's mouth particularly during bronchoconstriction induced by an exercise challenge test (ECT). This limitation may be overcome by calculating respiratory admittance (Ars), the inverse of respiratory impedance during an ECT.

Conditions

Asthma (Diagnosis)

Keywords

lung function testing; oscillometry; asthma

Outcome Measures

Primary Outcomes (1)

• Diagnostic performance of Ars

  Area under the ROC curves (AUC) for response to exercise challenge of Ars (computed from oscillometric parameters) compared with AUC of respiratory resistance to identify children with a positive challenge test and children with a negative challenge test

  Through study completion, an average of 1 month

Secondary Outcomes (2)

• Sensitivity of Ars

  Through study completion, an average of 1 month

• Specificity of Ars

  Through study completion, an average of 1 month

Study Arms (2)

Children with positive response to exercise challenge test

Children aged 5 to 16 years old who performed an exercise challenge test and had a decrease of ≥ 10% in FEV1 after test (FEV1 = forced expiratory volume in 1 sec obtained by forced spirometry)

Children with NEGATIVEresponse to exercise challenge test

Children aged 5 to 16 years old who performed an exercise challenge test and had a decrease of \< 10% in FEV1 after test (FEV1 = forced expiratory volume in 1 sec obtained by forced spirometry)

Eligibility Criteria

• Age: 5 Years - 16 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17)
• Sampling Method: Non-Probability Sample

Study Population

Data of children aged 5 to 16 years addressed by the pediatric pulmonologist to an exercise challenge test between January 2023 and April 2026 to the Pediatric Function Testing Department who have oscillometric and spirometric interpretable and reproducible measurements

You may qualify if:

• Children aged 5 to 16 years
• Children addressed by the pediatric pulmonologist to an exercise challenge test between January 2023 and April 2026
• Children with interpretable and reproducible oscillometric measurements
• Children with interpretable and reproducible spirometric measurements

You may not qualify if:

• Children who performed only spirometric measurements
• Children who performed only oscillometric measurements
• Children whose oscillometric and spirometric measurements are non-interpretable
• Children whose oscillometric and spirometric measurements are non-reproducible

Sponsors & Collaborators

• Central Hospital, Nancy, France: lead

Related Publications (3)

• Farre R. Measuring intra-subject changes in respiratory mechanics by oscillometry: impedance versus admittance. Eur Respir J. 2022 Oct 6;60(4):2201198. doi: 10.1183/13993003.01198-2022. Print 2022 Oct. No abstract available.

  PMID: 36028252 BACKGROUND

• Nguyen YT, Demoulin B, Schweitzer C, Bonabel-Chone C, Marchal F. Identification of bronchodilator responsiveness by forced oscillation admittance in children. Pediatr Res. 2007 Sep;62(3):348-52. doi: 10.1203/PDR.0b013e3180db2933.

  PMID: 17622963 BACKGROUND

• Ioan I, Coutier L, Bonabel C, Albrecht J, Demoulin B, Marchal F, Schweitzer C, Varechova S. Airway obstruction, upper airway artifact and response to bronchodilator in asthmatic and healthy children. Pediatr Pulmonol. 2015 Nov;50(11):1053-9. doi: 10.1002/ppul.23131. Epub 2014 Nov 10.

  PMID: 25384559 BACKGROUND

MeSH Terms

Conditions

Asthma; Disease

Condition Hierarchy (Ancestors)

Bronchial Diseases; Respiratory Tract Diseases; Lung Diseases, Obstructive; Lung Diseases; Respiratory Hypersensitivity; Hypersensitivity, Immediate; Hypersensitivity; Immune System Diseases; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Central Study Contacts

Iulia Ioan, MD PhD

CONTACT

+33 3 83 15 47 94; ic.ioan@chru-nancy.fr

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Head of Pediatric Function Testing Department

Study Record Dates

• First Submitted: August 12, 2026
• First Posted: August 18, 2026
• Study Start: August 25, 2026
• Primary Completion: August 25, 2026
• Study Completion: September 1, 2026
• Last Updated: August 19, 2026

Record last verified: 2026-08