Predictive Factors for a Positive Exercise Bronchial Hyperresponsiveness Test

NCT07766460 | Completed

• 1 other identifier: 2026PI119
• Study Type: observational
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

Exertional dyspnea has a significant impact on a child's daily life. Current guidelines recommend performing an exercise challenge test to confirm or rule out exercise-induced bronchoconstriction (EIB). But the test is not widely available. The objective of this research is to identify the clinical and respiratory functional factors predictive of a positive exercise challenge test in children.

Conditions

Asthma (Diagnosis)

Keywords

Exercise-induced wheezing; Dyspnea

Outcome Measures

Primary Outcomes (1)

• Presence of wheezing at exercise

  Presence of reported exercise-induced wheezing, as documented in the subject's electronic medical record (yes/no; binary variable).

  The test duration (3 hours)

Secondary Outcomes (7)

• Presence of reported dyspnea at exercise

  The test duration 3 hours

• Presence of reported cough at exercise

  The test duration 3 hours

• Presence of reported chest tightness at exercise

  The test duration 3 hours

• Functional parameters - FEV1 z-score at baseline

  The test duration 3 hours

• Reported atopy

  The test duration 3 hours

Study Arms (2)

Children without exercise-induced bronchocontriction

Children with a reduction in FEV1 \< 10% from baseline after the exercise challenge test

Children with exercise-induced bronchocontriction

Children with a reduction in FEV1 ≥ 10% from baseline after the exercise challenge test

Eligibility Criteria

• Age: 5 Years - 18 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

Children referred by a pediatric pulmonologist to the pediatric respiratory function testing department in 2024 and 2025 for an exercise test. Children with asthma diagnosed by a physician will be excluded.

You may qualify if:

• Children aged 5 to 18 years who performed an exercise challenge test during the years 2024 and 2025

You may not qualify if:

• Children with doctor-diagnosed asthma

Sponsors & Collaborators

• Central Hospital, Nancy, France: lead

Study Sites (1)

CHRU de Nancy

Nancy, France

Location

MeSH Terms

Conditions

Asthma; Disease; Dyspnea

Condition Hierarchy (Ancestors)

Bronchial Diseases; Respiratory Tract Diseases; Lung Diseases, Obstructive; Lung Diseases; Respiratory Hypersensitivity; Hypersensitivity, Immediate; Hypersensitivity; Immune System Diseases; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Respiration Disorders; Signs and Symptoms, Respiratory; Signs and Symptoms

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor MD PhD

Study Record Dates

• First Submitted: July 27, 2026
• First Posted: August 14, 2026
• Study Start: May 30, 2024
• Primary Completion: June 1, 2026
• Study Completion: June 8, 2026
• Last Updated: August 14, 2026

Record last verified: 2026-08

Locations

FR (1)