Polynucleotide-Hyaluronic Acid Gel With Xenograft for Alveolar Ridge Preservation

NCT07771257 | Not Yet Recruiting

• 1 other identifier: PER 631
• Study Type: interventional
• Target: 20
• Locations: 1 country
• Sites: 1

Brief Summary

This randomized controlled clinical trial will evaluate the efficacy of polynucleotide-hyaluronic acid gel combined with xenograft and collagen membrane for alveolar ridge preservation following tooth extraction. Twenty participants will be randomly allocated into two parallel groups. The test group will receive xenograft mixed with polynucleotide-hyaluronic acid gel and covered with a collagen membrane, while the control group will receive xenograft with a collagen membrane alone. Clinical and CBCT assessments will be performed at baseline and during follow-up. After 6 months, ridge dimensional changes will be evaluated and core biopsies will be obtained at the time of implant placement for histological assessment.

Conditions

Alveolar Ridge Preservation

Keywords

Socket Preservation; Alveolar Ridge Preservation; Polynucleotide; Hyaluronic Acid; Xenograft; Collagen Membrane

Outcome Measures

Primary Outcomes (1)

• Change in Buccal Bone Plate Height

  The height of the buccal bone plate will be measured using digital superimposition of Cone Beam Computed Tomography (CBCT) scans obtained at baseline and 6 months. Measurements will be recorded in millimeters

  Baseline and 6 months

Secondary Outcomes (4)

• Change in Palatal Bone Plate Height

  Baseline and 6 months

• Change in Horizontal Ridge Width

  Baseline and 6 months

• Percentage of New Vital Bone Formation

  6 months

• Percentage of Residual Graft Particles

  6 months

Study Arms (2)

Polynucleotide-Hyaluronic Acid Gel With Xenograft

EXPERIMENTAL

Alveolar ridge preservation using xenograft mixed with polynucleotide-hyaluronic acid gel and covered with a collagen membrane.

Other: Polynucleotide-Hyaluronic Acid Gel With Xenograft

Xenograft Alone

ACTIVE COMPARATOR

Alveolar ridge preservation using xenograft covered with a collagen membrane.

Other: Xenograft With Collagen Membrane

Interventions

Polynucleotide-Hyaluronic Acid Gel With Xenograft OTHER

Xenograft mixed with polynucleotide-hyaluronic acid gel and covered with a collagen membrane for alveolar ridge preservation after tooth extraction.

Polynucleotide-Hyaluronic Acid Gel With Xenograft

Xenograft With Collagen Membrane OTHER

Xenograft placed in the extraction socket and covered with a collagen membrane for alveolar ridge preservation after tooth extraction.

Xenograft Alone

Eligibility Criteria

• Age: 18 Years - 60 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• Patients aged 18-60 years.
• Patients free from systemic diseases affecting wound healing or bone regeneration or contraindicating oral surgery.
• Non-smokers with good oral hygiene.
• Patients requiring tooth extraction in non-infected sockets due to endodontic failure, non-restorable caries, or trauma, and who will receive implant treatment.
• Class I extraction sockets with intact alveolar bone walls.
• Presence of teeth adjacent to the extraction site.

You may not qualify if:

• Use of drugs affecting wound healing.
• Heavy smokers (\>10 cigarettes/day) or history of substance abuse.
• Pregnant or breastfeeding women.
• Previous grafting or surgical intervention in the study area.
• Uncontrolled and/or untreated periodontal disease (active periodontitis).
• Mentally or physically handicapped patients.

Sponsors & Collaborators

• Cairo University: lead

Study Sites (1)

Faculty of Dentistry, Cairo University

Cairo, Cairo Governorate, Egypt

Location

MeSH Terms

Interventions

Transplantation, Heterologous

Intervention Hierarchy (Ancestors)

Transplantation; Surgical Procedures, Operative

Study Officials

• Maryam Alabbas, BDS

  Cairo University

  PRINCIPAL INVESTIGATOR

• Manal Hosni

  Cairo University

  STUDY CHAIR

Central Study Contacts

Maryam Alabbas, BDS

CONTACT

+97366754440; maryam.alabbas@dentistry.cu.edu.eg

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Masking Details: The outcome assessor and biostatistician will be blinded to group allocation. Blinding of the operator is not applicable.
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Master's Student in Periodontology

Study Record Dates

• First Submitted: August 13, 2026
• First Posted: August 18, 2026
• Study Start: September 1, 2026
• Primary Completion (Estimated): April 1, 2027
• Study Completion (Estimated): April 1, 2027
• Last Updated: August 18, 2026

Record last verified: 2026-08

Data Sharing

• IPD Sharing: Will not share

Locations

EG (1)