Effect of GLP-1 Receptor Agonists on Periodontal Health and Response to Nonsurgical Periodontal Therapy

NCT07770906 | Not Yet Recruiting

• 1 other identifier: TS 168- KARAR 77
• Study Type: interventional
• Target: 40
• Locations: 0 countries
• Sites: N/A

Brief Summary

This study aims to evaluate the effects of glucagon-like peptide-1 receptor agonist (GLP-1 RA) use on periodontal health and the response to non-surgical periodontal therapy in individuals with obesity and periodontitis. Participants with obesity and periodontitis will be divided into two groups: those who have been using a GLP-1 RA for at least 3 months and those who are not using any medication for obesity. All participants will receive the same non-surgical periodontal treatment, including oral hygiene instruction, scaling, and root planing. Periodontal clinical measurements and gingival crevicular fluid samples will be collected before treatment and at 3 and 6 months after treatment. The study will compare changes in periodontal health and inflammatory markers between the two groups to determine whether GLP-1 RA use is associated with periodontal health and the response to non-surgical periodontal therapy.

Conditions

Periodontal Disease; Obesity & Overweight

Keywords

PERIODONTAL DISEASE; OBESİTY

Outcome Measures

Primary Outcomes (1)

• Probing Depth

  Baseline, 3 months- 6 months

Secondary Outcomes (1)

• Gingival Index

  Baseline, 3months- 6 months

Study Arms (2)

Title: GLP-1 Receptor Agonist Group

ACTIVE COMPARATOR

Procedure: non-surgical periodontal therapy

Control Group

PLACEBO COMPARATOR

Procedure: non-surgical periodontal therapy

Interventions

non-surgical periodontal therapy PROCEDURE

All participants will receive oral hygiene instructions, including instruction in the modified Bass toothbrushing technique. Non-surgical periodontal therapy will be performed under local anesthesia in two sessions and will include full-mouth subgingival instrumentation and scaling and root planing using ultrasonic instruments and Gracey curettes. No adjunctive antimicrobial agents will be used.

Control Group; Title: GLP-1 Receptor Agonist Group

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

• Age between 18 and 65 years
• Body mass index (BMI) ≥25 kg/m²
• Presence of at least 20 functional teeth
• Diagnosis of periodontitis
• For the GLP-1 receptor agonist group: regular use of a GLP-1 receptor agonist for at least 3 months

You may not qualify if:

• Age between 18 and 65 years
• Body mass index (BMI) ≥25 kg/m²
• Presence of at least 20 functional teeth
• Diagnosis of periodontitis
• For the GLP-1 receptor agonist group: regular use of a GLP-1 receptor agonist for at least 3 months

Sponsors & Collaborators

• Cukurova University: lead

MeSH Terms

Conditions

Periodontal Diseases; Obesity; Overweight

Condition Hierarchy (Ancestors)

Mouth Diseases; Stomatognathic Diseases; Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Central Study Contacts

bahar alkaya

CONTACT

+05368720327; balkaya@cu.edu.tr

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Masking Details: The outcomes assessor performing the periodontal clinical measurements will be blinded to the participants' GLP-1 receptor agonist use and group assignment.
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: ASSOCIATE PROFESSOR

Model Details: Participants with obesity and periodontitis will be included in two parallel groups according to their existing GLP-1 receptor agonist use. One group will consist of participants who have been using a GLP-1 receptor agonist for at least 3 months, while the control group will consist of participants who are not using any medication for obesity. Both groups will receive the same non-surgical periodontal therapy and will be followed for 6 months.

Study Record Dates

• First Submitted: August 13, 2026
• First Posted: August 18, 2026
• Study Start: September 1, 2026
• Primary Completion (Estimated): May 1, 2027
• Study Completion (Estimated): December 1, 2027
• Last Updated: August 20, 2026

Record last verified: 2026-08