Effect of Nonsurgical Periodontal Therapy on Salivary Biomarkers Related to Bone Turnover in Smoker and Nonsmoker Periodontitis Patients

NCT06270004 | Not Yet Recruiting

• 1 other identifier: nonsurgical periodontal
• Study Type: interventional
• Target: 30
• Locations: 0 countries
• Sites: N/A

Brief Summary

1. 1.To assess the alteration in the level of salivary osteopontin (OPN), osteonectin(ON) and histatin-1 following NSPT in smoker and nonsmoker unstable periodontitis patients at different time intervals(one month and three months) .
2. 2.To evaluate the response of clinical periodontal parameters ( plaque index ,bleeding on probing ,probing pocket depth ,clinical attachment loss)following NSPT in smoker and nonsmoker unstable periodontitis patients at different time intervals (one month and three months)

Conditions

Non Surgical Periodontal Therapy

Keywords

osteonectin; osteopontin; histatin1

Outcome Measures

Primary Outcomes (1)

• Effect of nonsurgical periodontal therapy(NSPT) on salivary biomarkers related to bone turnover in smoker and nonsmoker periodontitis patients.

  salivary concentration of osteopontin between smoker and nonsmoker unstable periodontitis patients following NSPT at different time intervals.

  baseline, one month and three months

Secondary Outcomes (2)

• Effect of nonsurgical periodontal therapy(NSPT) on salivary biomarkers related to bone turnover in smoker and nonsmoker periodontitis patients.

  baseline, one month and three months

• Effect of nonsurgical periodontal therapy(NSPT) on salivary biomarkers related to bone turnover in smoker and nonsmoker periodontitis patients

  baseline, one month and three months

Study Arms (2)

nonsmoker periodontitis patients

ACTIVE COMPARATOR

Other: nonsurgical periodontal therapy

smoker periodontitis patients

ACTIVE COMPARATOR

cigarette smoker more the three years ago

Other: nonsurgical periodontal therapy

Interventions

nonsurgical periodontal therapy OTHER

sonic scaler for scaling and polishing. Graces curettes numbers(1-2,3-4,5-6,7-8,9-10,11-12,13-14)for root surfaces debridement(RSD), instructions and motivation for dental arch

nonsmoker periodontitis patients; smoker periodontitis patients

Eligibility Criteria

• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

• participants will be systemically healthy without history of any systemic diseases.
• hadn't underwent periodontal treatment during the previous 6 months and not taken medication during the previous 3 months.
• present with at least 20 teeth, those who only diagnosed with 4-6 mm probing pocket depth, generalized ,unstable periodontitis who had bone loss \> 30% , probing probing pocket depth at ≥4mm . Periodontitis cases were defined if clinical attachment loss was detected at ≥2 non- adjacent teeth or when buccal (facial) showed clinical attachment loss ≥3mm associated with probing pocket depth \>3mm at ≥ 2 teeth .
• The patients in the smokers group will be current smokers ( cigarette smokers) with smoking habit for over 3 years

You may not qualify if:

• Subjects have any intraoral plaque retentive factors such as those wearing partial denture, crown and bridges, and orthodontic appliances ,furcation involved teeth, overhang filling, tooth anomaly.
• receiving antibiotic therapy during the previous 3 months.
• those with systemic diseases such as diabetes mellitus, cardiovascular or renal diseases, etc…., pregnant or lactating women, not willing to participate or continue to conduct the study.

Sponsors & Collaborators

• University of Baghdad: lead

Central Study Contacts

Aqeel Ali, baccalaureus

CONTACT

+96407705518935; aqeel.ali2205@codental.uobaghdad.edu.iq

Maha shukri, master

CONTACT

+96407716249206; mahashukri@codental.uobaghdad.edu.iq

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: OTHER
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Iraq ,baghdad

Model Details: smoker and non smoker patients with unstable periodontitis

Study Record Dates

• First Submitted: January 8, 2024
• First Posted: February 21, 2024
• Study Start: March 1, 2024
• Primary Completion: November 1, 2024
• Study Completion: December 1, 2024
• Last Updated: February 21, 2024

Record last verified: 2024-02

Data Sharing

• IPD Sharing: Will not share