Local and Systemic Inflammatory Bone Alterations Related to Dental Implant Survival.

NCT07766707 | Active Not Recruiting DMC

• 1 other identifier: 27/2025
• Study Type: observational
• Target: 192
• Locations: 1 country
• Sites: 1

Brief Summary

Introduction: Dental implants offer a durable, aesthetic, and functional option for tooth replacement. However, they are not immune to failure. Current literature has highlighted the importance of systemic factors (such as vitamin D deficiency and osteoporosis) and local factors (such as the presence of nearby periapical infections or implant placement in sites with a history of endodontic failure) that affect bone health. Hypothesis: Bone alterations-whether systemic or local-represent a risk factor for implant failure and peri-implantitis. Objectives: To analyze implant failure and marginal bone loss in patients with local and/or systemic bone alterations compared to patients without such conditions. Methods: Implant failures occurring in patients treated within the Master's Program in Oral Medicine, Surgery, and Implantology at the University of Barcelona (MCIO-UB) over the last 10 years will be analyzed and correlated with bone factors (local and systemic) recorded in their medical histories. Cases lacking the radiographic and clinical data necessary to conduct the study will be excluded. Population: A total of 3,500 implants have been placed, with failure rates ranging from 4% to 8% depending on the techniques used; consequently, the study sample will consist of 192 implants. Cohorts of successful implants will be established by matching patients of the same sex and within a ±5-year age range who did not experience implant failure.

Conditions

Peri Implant Mucositis; Peri Implant Bone Loss; Peri Implantitis; Calcium Deficiency; Phosphorus and Calcium Disorders; Vitamin D Deficiency; Renal Insufficiency / Therapy; Renal Insufficiency Chronic; Renal Insufficiency, Acute; Renal Insuficiency; Prothesis; Prosthesis and Implants; Diabetes (DM); Kidney Disease

Keywords

peri implantitis; dental prosthesis; vitamin D; Diabetes Mellitus; kidney disease

Outcome Measures

Primary Outcomes (1)

• Difference in the prevalence of implant failure and peri-implantitis between patients presenting with local and/or systemic alterations involving the bone.

  To see the differences of prevalences of all those factors affecting implants in the patients who present a success or failure of dental implants

  2013-2026

Secondary Outcomes (5)

• Relationship of osteoporosis and implant failure

  2013-2026

• Relationship of vitamine D levels and implant failure

  2013-2026

• Relationship between dental implant failure and dental failure

  2013-2026

• Relationship between the presence of an adjacent endodontically treated tooth and implant failure

  2013-2026

• Paper of dental prosthesis in implant failure

  2013-2026

Study Arms (2)

Implant Success

patients in which dental implants had not been lost since the positioning

Implant Failure

patients in which dental implants had been lost since the positioning

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

The sample will be selected from patients who have received dental implants at the University of Barcelona Dental Hospital (HOUB).

You may qualify if:

• Patients over 18 years of age
• Patients with implants placed within the last 10 years
• Patients with access to complete medical and dental records
• Patients with documented implant progression via periapical radiographs and/or OPG
• Patients with documented pre-implant tooth status
• Patients with blood test results from the 6 months prior to or following implant placement
• Implants lost due to peri-implant pathology causing bone resorption

Sponsors & Collaborators

• University of Barcelona: lead

Study Sites (1)

Odontologic Hospital of the University of Barcelona

Barcelona, Barcelona, 08970, Spain

Location

Related Publications (23)

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MeSH Terms

Conditions

Peri-Implantitis; Vitamin D Deficiency; Renal Insufficiency; Renal Insufficiency, Chronic; Acute Kidney Injury; Diabetes Mellitus; Kidney Diseases

Condition Hierarchy (Ancestors)

Periodontal Diseases; Mouth Diseases; Stomatognathic Diseases; Avitaminosis; Deficiency Diseases; Malnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Glucose Metabolism Disorders; Metabolic Diseases; Endocrine System Diseases

Study Officials

• José López López, University Professor

  University of Barcelona

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Masters Degree

Study Record Dates

• First Submitted: August 9, 2026
• First Posted: August 14, 2026
• Study Start: December 1, 2025
• Primary Completion (Estimated): October 15, 2026
• Study Completion (Estimated): February 15, 2027
• Last Updated: August 14, 2026

Record last verified: 2026-01

Data Sharing

• IPD Sharing: Will not share

Locations

ES (1)