Local Factors in the Onset/Progression of Peri-implantitis: A Retrospective Study

NCT07633912 | Completed DMC

• 1 other identifier: 18002909(B)
• Study Type: observational
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

With the increasing burden of peri-implantitis worldwide, interest in the management of this pathology has flourished. However, there is a lack of consensus in the search for a predictable therapy. Different therapeutic modalities have been advocated. Non-surgical therapy as a sole modality is often insufficient to resolve inflammation. Surgical interventions have demonstrated more favorable results. Among these, evidence supported the application of resective, reconstructive or combined approaches to limit progressive bone loss and achieve soft tissue health. However, to date, the most appropriate modality is unknown and the decision-making process derives from the understanding gained in the management of periodontitis. A very relevant aspect of peri-implantitis is that the prevalence tends to be higher at the patient level than at the implant level. This indicates that it is a pathology in which there are localized factors that may contribute to the onset and/or perpetuation of the pathology. Some of the factors that have been demonstrated in the literature point to the characteristics of the peri-implant soft tissues, as well as the position of the dental implants. However, the role of each local factor in the predisposition or protection of peri-implant disease or health is still largely unknown. The objective of this study is therefore to evaluate, in partially edentulous patients with multiple implants, the localized factors associated with peri-implantitis.

Conditions

Peri-Implantitis

Outcome Measures

Primary Outcomes (1)

• Peri-implantitis

  Bone loss (≥3mm) occurring with clinical signs of inflammation

  >12 months

Interventions

Dental implant DEVICE

Impact of implant-related local factors on the onset/progression of peri-implantitis

Eligibility Criteria

• Age: 18 Years - 90 Years
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Partially edentulous patients with dental implants exhibiting peri-implantitis

You may qualify if:

• Partially edentulous patients
• Peri-implantitis and non-peri-implantitis implants
• Readable x-ray and clinical signs of inflammation/health

You may not qualify if:

• Complete edentulous patients
• Inconsistent definition of peri-implantitis

Sponsors & Collaborators

• Center of Implantology, Oral and Maxillofacial Surgery, Badajoz, Spain: lead

Study Sites (1)

Centro de Implantologia Cirugia Oral y Maxilofacial

Badajoz, 06011, Spain

Location

MeSH Terms

Conditions

Peri-Implantitis

Interventions

Dental Implants

Condition Hierarchy (Ancestors)

Periodontal Diseases; Mouth Diseases; Stomatognathic Diseases

Intervention Hierarchy (Ancestors)

Dental Materials; Biomedical and Dental Materials; Dental Prosthesis; Prosthodontics; Dentistry; Prostheses and Implants; Equipment and Supplies; Manufactured Materials; Technology, Industry, and Agriculture

Study Officials

• Alberto Monje Correa, DDS, MS, PhD

  CICOM MONJE

  STUDY CHAIR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: December 4, 2024
• First Posted: June 8, 2026
• Study Start: August 10, 2024
• Primary Completion: January 10, 2025
• Study Completion: January 10, 2025
• Last Updated: June 8, 2026

Record last verified: 2024-12

Locations

ES (1)