NCT07764432

Brief Summary

The project is a multisite, three-group randomized control trial (RCT) with equal and parallel mixed-methods analysis that allows standardized measures combined with rich qualitative data to test hypotheses and answer research questions. Family caregivers (FCGs) of hospice cancer patients will be recruited and randomized into one of three groups: usual hospice care only (UC), usual care online support group (UCOSG) (without communication strategies), and the CHOOSE intervention group (with communication focus).

Trial Health

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Monitor

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
567

participants targeted

Target at P75+ for not_applicable

Timeline
52mo left

Started Feb 2027

Longer than P75 for not_applicable

Geographic Reach
1 country

1 active site

Status
not yet recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

August 6, 2026

Completed
8 days until next milestone

First Posted

Study publicly available on registry

August 14, 2026

Completed
6 months until next milestone

Study Start

First participant enrolled

February 1, 2027

Expected
4.2 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

April 30, 2031

Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

April 30, 2031

Last Updated

August 14, 2026

Status Verified

August 1, 2026

Enrollment Period

4.2 years

First QC Date

August 6, 2026

Last Update Submit

August 6, 2026

Conditions

Keywords

CaregiversFamily CaregiversCancer Caregivers

Outcome Measures

Primary Outcomes (2)

  • Changes in Patient Health Questionnaire (PHQ-9) score

    The PHQ-9 is a 9-item questionnaire that assesses patient depression. The 9-items are ranked by Likert Scale from 0 - Not at all, 1 - Several days, 2 - More than half the days, and 3 - nearly every day. Scores range from 0-27 with lower scores indicating no or minimal depression and higher scores indicating moderate to severe depression.

    Baseline and every 14 days until completion of study (estimated total time 3 months)

  • Changes in General Anxiety Disorder (GAD-7) score

    The GAD-7 includes 7-items ranked by Likert scale to measure anxiety severity over the past two weeks. Each item is ranked by 4-point Likert scale as follows: 0-Not at all, 1-Several days, 2-More than half the days, and 3-Nearly every day. Scores range from 0-21, with a higher score indicating higher anxiety.

    Baseline and every 14 days until completion of study (estimated total time 3 months)

Secondary Outcomes (13)

  • Changes in Patient-Reported Outcomes Measurement Information System (PROMIS) Physical Well Being Domain Score

    Baseline and every 14 days until completion of study (estimated total time 3 months)

  • Changes in PROMIS Mental Well Being Score

    Baseline and every 14 days until completion of study (estimated total time 3 months)

  • Changes in University of California Los Angeles (UCLA) Loneliness Scale-3 score

    Baseline and every 14 days until completion of study (estimated total time 3 months)

  • Changes in Zarit Burden-7 Interview score

    Baseline and every 14 days until completion of study (estimated total time 3 months)

  • Changes in Caregiver Quality of Life Index-Revised (CQLI-R) score

    Baseline and every 14 days until completion of study (estimated total time 3 months)

  • +8 more secondary outcomes

Study Arms (3)

Usual Care (UC)

ACTIVE COMPARATOR

Patients randomized to the UC arm will receive the standard of care of intermittent hospice team support.

Other: Intermittent Hospice Team Support

Usual Care Online Social Support (UCOSG)

ACTIVE COMPARATOR

Patients randomized to the UCOSG arm will have access to an online support group in addition to the standard of care of intermittent hospice team support. The online support group is led by an untrained facilitator.

Other: Intermittent Hospice Team SupportOther: Online Support Group with untrained facilitator

CHOOSE Intervention

EXPERIMENTAL

Patients randomized to the CHOOSE intervention will have access to standard of care of intermittent hospice team support and access to an online support group led by a trained facilitator.

Other: Intermittent Hospice Team SupportOther: Online Support Group with trained facilitator

Interventions

Intermittent hospice team support will be provided per standard of care guidelines.

CHOOSE InterventionUsual Care (UC)Usual Care Online Social Support (UCOSG)

The online support group will be held via private, hidden Facebook. The online support group will be led by an untrained facilitator whose role is to enroll participants and maintain guidelines. Specifically, the untrained facilitator has the following roles: enrolls individuals in the group, monitors the discussion to maintain the guidelines to protect the group's integrity, provides information on resources for technical assistance, and notes any outside online groups to which they belong.

Usual Care Online Social Support (UCOSG)

The online support group will be held via private, hidden Facebook. The online support group led by a trained facilitator focuses on building safe communication and encouraging participant engagement. The trained facilitator has the following roles: enrolls individuals in the group, monitors the discussion to enforce the guidelines and protect the group's integrity, provides technical assistance, moderates group discussions, initiates threads using direct and indirect strategies and communication topic openings, builds a safe environment for communication, encourages participation, and organizes and coordinates Facebook Live activities.

CHOOSE Intervention

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)
Eligibility Criteria: * Family caregiver of cancer patient receiving hospice care from an affiliated hospice organization. Only 1 FCG per patient may be enrolled. * At least 18 years of age. * Can speak and understand English. * Able to access the internet. * Has a Facebook account or is willing to create a Facebook account in order to be in this study

Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.

Sponsors & Collaborators

Study Sites (1)

Washington University School of Medicine

St Louis, Missouri, 63110, United States

Location

Related Links

Study Officials

  • Debra P Oliver, PhD, MSW

    Washington University School of Medicine

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Debra P Oliver, PhD, MSW

CONTACT

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
HEALTH SERVICES RESEARCH
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

August 6, 2026

First Posted

August 14, 2026

Study Start (Estimated)

February 1, 2027

Primary Completion (Estimated)

April 30, 2031

Study Completion (Estimated)

April 30, 2031

Last Updated

August 14, 2026

Record last verified: 2026-08

Data Sharing

IPD Sharing
Will share

De-identified data and metadata from the project will be archived through the Washington University School of Medicine institutional data repository, Digital Commons Data@Becker. Survey data will be stored in CSV format and transcripts of audio-record interviews will be stored in TXT format.

Shared Documents
STUDY PROTOCOL, SAP, ICF
Time Frame
Data will be available no later than at the time of publication or by the end of the award period, whichever occurs earlier. The duration of data preservation and sharing will be governed by the retention policies of Digital Commons Data@Becker. Currently, the retention policy of Digital Commons Data@Becker ensures perpetual availability of all data shared in the repository, with contingency plans in place for potential changes in repository hosting.
Access Criteria
De-identified data will be available via controlled access only through Data Use Agreement (DUA).

Locations