NCT06634368

Brief Summary

Hospital stays are stressful for the family and friends who care for adults with dementia. Following hospital discharge, adults with dementia often have increased care needs, which places new caregiving demands on their family and friends. Family and friends are critical to ensuring that Veterans with dementia can live safely in the community following discharge. Healthcare systems have an opportunity to support family and friends of adults with dementia by addressing dementia-specific caregiving challenges that arise during the transition from hospital to home. The investigators are comparing two different support programs for family and friends of hospitalized adults with dementia. The two programs are Hospital GamePlan4Care and Caregiver Education. Hospital GamePlan4Care was developed with feedback from people who care for Veterans with dementia. Hospital GamePlan4Care helps caregivers build skills to care for someone with dementia recently discharged from the hospital. It includes a written handbook, online training on the Hospital GamePlan4Care website, and phone calls with a dementia care specialist. The online training is tailored to the caregiver. The Caregiver Education program provides information that helps caregivers care for someone recently hospitalized. It includes a written handbook, recommendations for high-quality online resources, and phone calls with a dementia care specialist. Both programs will start when the adult with dementia is hospitalized. Each program lasts at least three months. To be eligible, the caregiver must care for a Veteran with dementia admitted to the Michael E. DeBakey VA Medical Center in Houston, Texas. Caregivers interested in participating and passing eligibility screening will be enrolled in the study for at least three months. Each enrolled caregiver will have a 50% chance of being enrolled in the Hospital GamePlan4Care group or the Caregiver Education group (like flipping a coin). Both groups will be asked to complete several questionnaires about their needs as a caregiver and their well-being. Questionnaires will be completed at the beginning of the study and one and three months after the Veteran is discharged from the hospital. Each questionnaire should take 30-60 minutes to complete.

Trial Health

77
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
50

participants targeted

Target at P25-P50 for not_applicable

Timeline
1mo left

Started Feb 2025

Geographic Reach
1 country

1 active site

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress95%
Feb 2025May 2026

First Submitted

Initial submission to the registry

October 7, 2024

Completed
2 days until next milestone

First Posted

Study publicly available on registry

October 9, 2024

Completed
4 months until next milestone

Study Start

First participant enrolled

February 4, 2025

Completed
1.3 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

May 30, 2026

Expected
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

May 30, 2026

Last Updated

January 8, 2026

Status Verified

January 1, 2026

Enrollment Period

1.3 years

First QC Date

October 7, 2024

Last Update Submit

January 6, 2026

Conditions

Keywords

DementiaHospitalizationPatient DischargeCaregiver Burden

Outcome Measures

Primary Outcomes (4)

  • Change in Zarit Caregiving Burden Interview (12-item)

    Each item represents a statement related to an aspect of perceived burden. All questions are answered as never (0 points), rarely (1 point), sometimes (2 points), quite frequently (3 points), or nearly always (4 points). A total score will be obtained by summing all items with higher scores indicating higher rates of burden (range: 0-48).

    Baseline, 30 days and 90 days

  • Change in Center for Epidemiological Studies Depression Scale (CES-D) (10-item)

    The CES-D provides a list of feelings and behaviors. For each item, respondents report how often they have felt that way in the past week with each item receiving a score from 0-3. A total score will be obtained by summing scores for all items with higher scores indicating higher levels of depressed symptoms (range: 0-30).

    Baseline, 30 days, and 90 days

  • Change in Self-Rated Health (1-item)

    The investigators will use the single self-rated health item: "In general, would you say your health is:" with response options of Excellent, Very Good, Good, Fair, and Poor

    Baseline, 30 days, and 90 days

  • Change in Neuropsychiatric Inventory Questionnaire

    The Neuropsychiatric Inventory Questionnaire includes a list of 12 symptoms (e.g. delusions, hallucinations, agitation/aggression). For each symptom, the caregiver responds if the symptom was present in the past month (yes/no), the severity of the symptom if present (1-3), and the level of distress the caregiver feels due to that symptom (0-5). Higher scores indicate higher severity and greater distress due to that symptom.

    Baseline, 30 days, and 90 days

Secondary Outcomes (2)

  • Change in Self-Efficacy for Caregiving (CSES-8)

    Baseline, 30 days, and 90 days

  • Change in Benjamin Rose Institute Unmet Need Scale

    Baseline, 30 days, and 90 days

Other Outcomes (2)

  • Change in VA Unplanned Acute Care Use

    30 days and 90 days

  • Change in VA Home and Community-Based Services

    30 days and 90 days

Study Arms (2)

Hospital GamePlan4care

EXPERIMENTAL

Tailored caregiver skills training and support for caregiving for a person with dementia

Behavioral: Hospital GamePlan4Care

Health Education

ACTIVE COMPARATOR

Education on general caregiving topics.

Other: Health Education

Interventions

The Hospital GamePlan4Care intervention will include access to a written VA Care Transitions handbook, access to the GamePlan4Care website for skills training, 11 emails encouraging them to visit the website, and four phone calls with a dementia care specialist to tailor the training to the caregiver's needs over a 3-month period.

Hospital GamePlan4care

Caregivers in the health education arm will receive a VA Care Transitions Handbook, 4 emails with a weblink to a general caregiving topic, and 4 phone calls to confirm that the emails were received over a 3-month period.

Health Education

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • years of age or older
  • provide care for a Veteran with a diagnosis of Alzheimer's Disease or related dementias or a Veteran with a prescription for a medication for dementia listed in CPRS who is admitted to the hospital at the Michael E. DeBakey VA Medical Center
  • Veteran must be experiencing signs of dementia as verified by a score of 2 or greater on the AD-8
  • provide at least eight hours of care or supervision per week to the Veteran with dementia
  • provide care primarily due to a personal relationship, rather than a financial relationship
  • have access to a telephone
  • have access to a tablet or computer with internet access
  • report using the computer or tablet to access the internet at least three times per week
  • speak English

You may not qualify if:

  • unable to complete informed consent

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Michael E. DeBakey VA Medical Center, Houston, TX

Houston, Texas, 77030-4211, United States

RECRUITING

MeSH Terms

Conditions

DementiaCaregiver Burden

Condition Hierarchy (Ancestors)

Brain DiseasesCentral Nervous System DiseasesNervous System DiseasesNeurocognitive DisordersMental DisordersStress, PsychologicalBehavioral SymptomsBehavior

Study Officials

  • Molly Horstman, MD MS

    Michael E. DeBakey VA Medical Center, Houston, TX

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Molly Horstman, MD MS

CONTACT

Timothy J Zhou, MA

CONTACT

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
OUTCOMES ASSESSOR
Purpose
SUPPORTIVE CARE
Intervention Model
PARALLEL
Model Details: This is a single-blind, parallel group, randomized pilot trial of a 3-month caregiver support intervention for caregivers of hospitalized Veterans with dementia compared to health education. Participants will be assigned at random to the intervention (Hospital GamePlan4Care) or health education control. Assessment of the primary and secondary outcomes will occur pre-intervention at baseline and post-intervention at 1 and 3 months.
Sponsor Type
FED
Responsible Party
SPONSOR

Study Record Dates

First Submitted

October 7, 2024

First Posted

October 9, 2024

Study Start

February 4, 2025

Primary Completion (Estimated)

May 30, 2026

Study Completion (Estimated)

May 30, 2026

Last Updated

January 8, 2026

Record last verified: 2026-01

Data Sharing

IPD Sharing
Will share

The investigators will provide a de-identified dataset compliant with VA data security policy to the public upon request to the principal investigator.

Time Frame
After the data is analyzed and published

Locations