Donor Ankle Sensorimotor Recovery After ACL Reconstruction With a Peroneus Longus Tendon Autograft

NCT07762989 | Not Yet Recruiting

• 1 other identifier: 2026-1435
• Study Type: observational
• Target: 20
• Locations: 1 country
• Sites: 1

Brief Summary

This prospective longitudinal observational cohort study will characterize recovery of donor-ankle sensorimotor function in adults who have undergone primary anterior cruciate ligament reconstruction using a peroneus longus tendon autograft. Twenty participants aged 18 to 55 years will be evaluated at postoperative 6-8 weeks, 3 months, and 6 months. The donor limb and the contralateral non-donor limb will be compared using surface electromyography of the peroneus longus, force-platform measures of postural control, inertial-sensor gait analysis, active ankle joint-position sense testing, and clinical and patient-reported foot and ankle function measures. The study does not assign the surgical procedure or rehabilitation treatment.

Conditions

Anterior Cruciate Ligament Injury; Anterior Cruciate Ligament Reconstruction; Donor Site Complication

Keywords

peroneus longus tendon autograft; donor ankle; sensorimotor function; surface electromyography; postural control; proprioception; gait analysis

Outcome Measures

Primary Outcomes (1)

• Change in Mean Center of Pressure Velocity During Single-Leg Balance

  Mean center of pressure (CoP) velocity during a 10-second single-leg stance, assessed separately with eyes open and eyes closed on KFORCE Plates. Each limb will be tested in three trials, and the mean for each condition will be used. Values are expressed in millimeters per second (mm/s); lower values indicate less postural sway. Change from the postoperative 6-8-week assessment to 3 and 6 months and donor-versus-contralateral limb differences will be evaluated.

  Postoperative 6-8 weeks, 3 months, and 6 months

Secondary Outcomes (18)

• Change in CoP Path Length During Single-Leg Balance

  Postoperative 6-8 weeks, 3 months, and 6 months

• Change in CoP Ellipse Area During Single-Leg Balance

  Postoperative 6-8 weeks, 3 months, and 6 months

• Change in Mean CoP Velocity During Double-Leg Balance

  Postoperative 6-8 weeks, 3 months, and 6 months

• Change in CoP Path Length During Double-Leg Balance

  Postoperative 6-8 weeks, 3 months, and 6 months

• Change in CoP Ellipse Area During Double-Leg Balance

  Postoperative 6-8 weeks, 3 months, and 6 months

Study Arms (1)

Peroneus Longus Tendon Autograft ACLR Cohort

Adults after primary unilateral ACL reconstruction using a peroneus longus tendon autograft. Participants will undergo observational assessments at postoperative 6-8 weeks, 3 months, and 6 months. Donor-limb measures will be compared with measurements from the contralateral non-donor limb. No intervention is assigned by the study.

Procedure: Anterior Cruciate Ligament Reconstruction Using a Peroneus Longus Tendon Autograft

Interventions

Anterior Cruciate Ligament Reconstruction Using a Peroneus Longus Tendon Autograft PROCEDURE

Participants undergo primary anterior cruciate ligament reconstruction using a peroneus longus tendon autograft as part of their routine clinical care. The graft choice and surgical procedure are determined by the treating orthopedic surgeon independently of study participation. The study does not assign or modify the graft choice, surgical technique, or postoperative rehabilitation. Participants receive routine postoperative rehabilitation according to their clinical needs, while donor-ankle sensorimotor recovery is assessed prospectively at 6-8 weeks, 3 months, and 6 months after surgery.

Peroneus Longus Tendon Autograft ACLR Cohort

Eligibility Criteria

• Age: 18 Years - 55 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

Adults aged 18 to 55 years who have undergone primary unilateral anterior cruciate ligament reconstruction using a peroneus longus tendon autograft as part of routine clinical care and are referred to the Sports Health Unit, Department of Physiotherapy and Rehabilitation, Faculty of Health Sciences, Gazi University, for postoperative rehabilitation and functional assessment. Eligible participants will be enrolled consecutively during the study period.

You may qualify if:

• Age 18 to 55 years.
• Unilateral primary anterior cruciate ligament tear confirmed by clinical examination and magnetic resonance imaging.
• Primary anterior cruciate ligament reconstruction performed using a peroneus longus tendon autograft.
• Able and willing to attend the postoperative assessments at 6-8 weeks, 3 months, and 6 months.
• Written informed consent provided before study participation.

You may not qualify if:

• Multiligament knee injury.
• Previous surgery on the index knee or donor ankle.
• Pre-existing ankle instability or major foot or ankle pathology.
• Neurological or neuromuscular disease.
• Inflammatory or systemic disease that may affect the assessments.
• Major lower-extremity deformity that may affect the assessments.
• Unable to complete the postoperative rehabilitation program or scheduled follow-up assessments.

Sponsors & Collaborators

• Gazi University: lead

Study Sites (1)

Gazi University Faculty of Health Sciences, Department of Physiotherapy and Rehabilitation, Sports Health Unit

Çankaya, Ankara, 06490, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Anterior Cruciate Ligament Injuries

Condition Hierarchy (Ancestors)

Knee Injuries; Leg Injuries; Wounds and Injuries

Study Officials

• Dudu Ozdemir Can, Msc

  Gazi University

  PRINCIPAL INVESTIGATOR

• Nihan Karatas, Prof. Dr.

  Gazi University

  STUDY DIRECTOR

Central Study Contacts

Dudu Ozdemir Can, Msc

CONTACT

+90 5534448492; duduozdemir@gazi.edu.tr

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: PhD Candidate, Department of Physiotherapy and Rehabilitation

Study Record Dates

• First Submitted: August 10, 2026
• First Posted: August 13, 2026
• Study Start (Estimated): August 22, 2026
• Primary Completion (Estimated): August 1, 2027
• Study Completion (Estimated): October 1, 2027
• Last Updated: August 13, 2026

Record last verified: 2026-08

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)