Neuromuscular Profiles After Anterior Cruciate Ligament Reconstruction

NCT07792863 | Not Yet Recruiting

• 2 other identifiers: NEURO-ACL-ISOEMG2026-A01124-47
• Study Type: observational
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

The NEURO-ACL-ISOEMG study is an observational, cross-sectional, exploratory study conducted in patients between 4 and 12 months after anterior cruciate ligament (ACL) reconstruction. The primary objective is to describe the joint distribution of isokinetic muscle strength and surface electromyographic (sEMG) activation parameters of the quadriceps and hamstrings in order to explore different neuromuscular profiles under clinical conditions. The study combines data from the routine functional assessment, including isokinetic strength measurements and a single-leg hop test, with surface electromyography and patient-reported questionnaires assessing knee self-efficacy, kinesiophobia, symptoms, and knee function.

Conditions

Anterior Cruciate Ligament Injury

Keywords

Anterior Cruciate Ligament Reconstruction; Neuromuscular Recovery; Isokinetic Strength; Surface Electromyography; Quadriceps; Hamstrings; Muscle Activation; Functional Assessment

Outcome Measures

Primary Outcomes (1)

• Distribution of Neuromuscular Profiles

  Participants will be classified into neuromuscular profiles based on the combined pattern of isokinetic strength and surface electromyographic activation of the quadriceps and hamstrings. The primary outcome will be the proportion of participants belonging to each identified neuromuscular profile, expressed as a percentage of the study population.

  During the single study visit, between 4 and 12 months after ACL reconstruction

Secondary Outcomes (4)

• Surface Electromyographic Activity During the Single Leg Hop for Distance

  During the single study visit, between 4 and 12 months after ACL reconstruction

• Distribution of Participants Across Neuromuscular Profile

  During the single study visit, between 4 and 12 months after ACL reconstruction

• Correlation Between Neuromuscular Parameters and Functional and Patient-Reported Outcomes

  During the single study visit, between 4 and 12 months after ACL reconstruction

• Completeness of Neuromuscular and Functional Assessment Data

  During the single study visit, between 4 and 12 months after ACL reconstruction

Study Arms (1)

Patients After ACL Reconstruction

Adults evaluated between 4 and 12 months after anterior cruciate ligament (ACL) reconstruction as part of their routine functional assessment. Participants undergo isokinetic strength assessment and a single-leg hop test as part of routine care, complemented for the study by surface electromyography and patient-reported questionnaires assessing knee self-efficacy, kinesiophobia, symptoms, and knee function.

Other: Neuromuscular and Patient-Reported Assessmen

Interventions

Neuromuscular and Patient-Reported Assessmen OTHER

Surface electromyography of the quadriceps and hamstrings is performed using surface electrodes. Participants also complete the Knee Self-Efficacy Scale (K-SES), Tampa Scale for Kinesiophobia (TSK), and International Knee Documentation Committee (IKDC) questionnaire. These assessments are performed during the same visit as the routine functional assessment.

Patients After ACL Reconstruction

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Adults who underwent anterior cruciate ligament (ACL) reconstruction and are evaluated between 4 and 12 months postoperatively during a routine functional assessment at the study site.

You may qualify if:

• Anterior cruciate ligament (ACL) reconstruction.
• Postoperative period between 4 and 12 months.
• Age 18 years or older.
• Affiliation with or beneficiary of a social security scheme.
• Ability to understand the study information and to express non-opposition to participation.

You may not qualify if:

• Persons under guardianship, curatorship, or another legal protection measure.
• Any condition preventing safe performance of isokinetic testing, including significant pain, significant joint effusion, substantial limitation of joint range of motion, clinical knee instability, or an ongoing postoperative complication.
• Opposition to participation in the study.

Sponsors & Collaborators

• Hopitaux de Saint-Maurice: lead

Study Sites (1)

Hôpitaux Paris Est Val-de-Marne - Service de rééducation orthopédique et traumatologie

Saint-Maurice, Demande, 94410, France

Location

MeSH Terms

Conditions

Anterior Cruciate Ligament Injuries

Condition Hierarchy (Ancestors)

Knee Injuries; Leg Injuries; Wounds and Injuries

Study Officials

• Sylvain BS BELOT, md

  Hopitaux Paris Est Val-de-Marne

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Sylvain SB BELOT, MD

CONTACT

+33143966383; sylvain.belot@hpevm.fr

Auriane AS SLAMA

CONTACT

+33143967556; auriane.slama@hpevm.fr

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: August 21, 2026
• First Posted: August 28, 2026
• Study Start (Estimated): September 1, 2026
• Primary Completion (Estimated): December 1, 2026
• Study Completion (Estimated): December 31, 2026
• Last Updated: August 28, 2026

Record last verified: 2026-08

Data Sharing

• IPD Sharing: Will not share

Locations

FR (1)