Effect of Artificial Intelligence Based Cognitive Training on Sleep Disorders and Quality of Life in Patients With Multiple Sclerosis

NCT07762326 | Not Yet Recruiting

• 1 other identifier: P.T.REC/012/006521
• Study Type: interventional
• Target: 40
• Locations: 0 countries
• Sites: N/A

Brief Summary

this study will be conducted to investigate the effect of artificial intelligence (AI) based cognitive training on sleep disorders and quality of life in patients with multiple sclerosis.

Conditions

Multiple Sclerosis

Keywords

Artificial Intelligence Based Cognitive Training; Sleep Disorders; Quality of Life; Multiple Sclerosis

Outcome Measures

Primary Outcomes (2)

• sleep disability

  Pittsburgh Sleep Quality Index will be used to assess sleep disability. it gives impression on sleep quality, sleep latency, sleep duration, usual sleep efficiency, sleep disturbances, use of sleeping medication, and daytime dysfunction over one month, The sum of scores for these seven components yields one global score. Scoring of the answers is based on a 0 to 3 scale and a global sum equal or larger than 5 indicates a "poor" sleeper

  up to eight weeks

• daytime sleepiness

  Epworth Sleepiness Scale will be used to assess daytime sleepiness. It measures the general level of daytime sleepiness it is composed of 8 items to rate on a 4 -point scale (0-3). A higher score indicates higher level of daytime sleepiness. Using a cut-off score \> 10, it is possible to identify individuals with excessive daytime sleepiness. Scores \>16 indicates ever sleepiness

  up to eight weeks

Secondary Outcomes (5)

• cognitive disability

  up to eight weeks

• oxygen saturation

  up to eight weeks

• heart rate

  up to eight weeks

• life disability

  up to eight weeks

• fatigue severity

  up to eight weeks

Study Arms (2)

cognitive Therapy by artificial intillegence

EXPERIMENTAL

Twenty patients with multiple sclerosis will receive a cognitive therapy by Lumosity application in addition to a designed physical-therapy program 3 times per week for 8 weeks

Other: cognitive Therapy by artificial intillegence; Other: designed physical-therapy program

designed physical-therapy program

ACTIVE COMPARATOR

Twenty patients with multiple sclerosis will receive a designed physical-therapy program 3 times per week for 8 weeks)

Other: designed physical-therapy program

Interventions

cognitive Therapy by artificial intillegence OTHER

The patients will receive cognitive therapy by an artificial intelligence application called Lumosity. Lumosity is an online cognitive training that can incredibly engage the individual's innate neuroplasticity, making the person smarter. Perhaps Lumosity training actually increases the release of dopamine, the neurochemical that is very crucial for many brain functions, and the puls-designed physical therapy program

cognitive Therapy by artificial intillegence

designed physical-therapy program OTHER

Patients will receive designed physical-therapy program in the form of sleep and bedtime restrictions, stimulus control instructions, education for sleep and promoting good sleep habits (or sleep hygiene), teaching relaxation skills

cognitive Therapy by artificial intillegence; designed physical-therapy program

Eligibility Criteria

• Age: 25 Years - 40 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• Patient's age ranges from 25-40 years.
• Patient with EDSS not more than 5.
• Patients who have no relapses for the previous three months.
• Patients with sufficient cognitive abilities that enables them to understand and follow
• instructions with a score more than 24 according to the Mini-Mental State Examination scale

You may not qualify if:

• Mechanical or neuromascular problems.
• Cardiovascular problems (unstable angina, recent myocardial infarction within the last three months, congestive heart failure, significant heart valve dysfunction, or unstable hypertension) or pulmonary disorders.
• Auditory problems.
• Sensory impairment caused by other diseases except the MS such as diabetes mellitus.

Sponsors & Collaborators

• Cairo University: lead

MeSH Terms

Conditions

Multiple Sclerosis; Sleep Wake Disorders

Condition Hierarchy (Ancestors)

Demyelinating Autoimmune Diseases, CNS; Autoimmune Diseases of the Nervous System; Nervous System Diseases; Demyelinating Diseases; Autoimmune Diseases; Immune System Diseases; Neurologic Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Mental Disorders

Central Study Contacts

rania hamed, master

CONTACT

01112084518; Raniahamed542@gmail.com

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Masking Details: opaque sealed envelope
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: principle investigator : rania hamed rashad ahmed

Model Details: Cognitive training by artificial intillegence and designed physical therapy

Study Record Dates

• First Submitted: August 5, 2026
• First Posted: August 13, 2026
• Study Start (Estimated): August 20, 2026
• Primary Completion (Estimated): March 30, 2027
• Study Completion (Estimated): March 30, 2027
• Last Updated: August 13, 2026

Record last verified: 2026-08