The Use of Advanced Platelet-rich Fibrin in Mandibular Third Molar Surgery

NCT07761338 | Completed

• 1 other identifier: H-22029533
• Study Type: observational
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of the study is to quantify the levels of platelets and inflammatory markers in A-PRF from a standard venous whole blood sample, and to evaluate the effect of A-PRF on postoperative discomfort and complications following surgical removal of M3. The study will be prospective and include 60 patients referred to Specialtandlægerne Vestergade for surgical removal of one M3. It is expected that the study will contribute with important information on the impact of A-PRF on postoperative sequelae and complications following surgical removal of mandibular third molars.

Conditions

Third Molars Extraction

Outcome Measures

Primary Outcomes (1)

• Levels of thrombocytes and growth factors in advanced platelet-rich fibrin

  Quantification of thrombocytes and specific growth factors (FGF, TGH-B1, VEGF, PDGF-B) released from advanced platelet-rich fibrin measured in concentration levels

  From enrollment to one week following surgery

Interventions

Third molar PROCEDURE

Evaluate the level of thrombocytes and growth factors in A-PRF and whole blood sample

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Healthy patients with indication for surgical removal of mandibular third molar

You may qualify if:

• indication for surgical removal of mandibular third molar

You may not qualify if:

• breastfeading, pregnancy

Sponsors & Collaborators

• University of Copenhagen: lead

Study Sites (1)

University of Copenhagen

Copenhagen, Denmark

Location

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 1 Week
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: September 18, 2024
• First Posted: August 12, 2026
• Study Start: October 1, 2024
• Primary Completion: December 31, 2024
• Study Completion: January 31, 2025
• Last Updated: August 12, 2026

Record last verified: 2024-09

Data Sharing

• IPD Sharing: Will not share

Locations

DK (1)