Effect of Post-operative Chlorhexidine on Postoperative Pain and Complications After Surgical Removal of Mandibular Third Molars
RITOR
1 other identifier
interventional
145
1 country
1
Brief Summary
This study aimed to assess the impact of postoperative chlorhexidine use on pain management following mandibular third molar removal In this prospective, randomized controlled trial,130 patients who underwent mandibular third molar surgical removal were divided into two groups: one group used chlorhexidine for postoperative rinsing and the other did not rinse. Pain levels, measured using the Numeric Rating Scale (NRS), were recorded daily for the first seven days post-surgery. Paired-samples t-tests were utilized for data analysis.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for not_applicable
Started Sep 2021
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
September 1, 2021
CompletedPrimary Completion
Last participant's last visit for primary outcome
March 24, 2022
CompletedStudy Completion
Last participant's last visit for all outcomes
August 19, 2022
CompletedFirst Submitted
Initial submission to the registry
March 10, 2025
CompletedFirst Posted
Study publicly available on registry
March 18, 2025
CompletedMarch 18, 2025
March 1, 2025
7 months
March 10, 2025
March 17, 2025
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Postoperative pain after removal of third molar
The primary endpoint is the difference in the postoperative pain measured on a numerical rating scale (NRS) evaluated at seven days
7 days after the inclusion pain was measured on a numerical rating scale
Secondary Outcomes (1)
Post-operative complications
7 days after the treatment the patient was seen at the outpatient clinic for clinical assessment. At this moment the number of patients with alveolitis, foodimpaction and bleeding was scored.
Study Arms (2)
Post-operative rinsing with chlorhexidine
OTHERIn the rinsing group, the patients received a bottle of 0,2% chlorhexidine
No post-operative rinsing
NO INTERVENTIONThose allocated to the control group received no post-operative rinsing
Interventions
In the rinsing group, the patients received a bottle of 0,2% chlorhexidine
Eligibility Criteria
You may qualify if:
- healthy adults (18+) referred by their dentist for third molar removal
You may not qualify if:
- active pericoronitis or other infections
- planned coronectomy
- trismus
- chronic pain
- pregnancy
- known allergies to local anesthesia
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Isalalead
Study Sites (1)
Isala Hospital
Zwolle, Overijssel, 8025AB, Netherlands
Related Publications (1)
Ghaeminia H, Hoppenreijs TJ, Xi T, Fennis JP, Maal TJ, Berge SJ, Meijer GJ. Postoperative socket irrigation with drinking tap water reduces the risk of inflammatory complications following surgical removal of third molars: a multicenter randomized trial. Clin Oral Investig. 2017 Jan;21(1):71-83. doi: 10.1007/s00784-016-1751-1. Epub 2016 Feb 27.
PMID: 26922634BACKGROUND
MeSH Terms
Interventions
Intervention Hierarchy (Ancestors)
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- DOUBLE
- Who Masked
- PARTICIPANT, INVESTIGATOR
- Purpose
- PREVENTION
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Oral Surgeon and Principal Investigator
Study Record Dates
First Submitted
March 10, 2025
First Posted
March 18, 2025
Study Start
September 1, 2021
Primary Completion
March 24, 2022
Study Completion
August 19, 2022
Last Updated
March 18, 2025
Record last verified: 2025-03
Data Sharing
- IPD Sharing
- Will not share