Effects of Low-level Laser Therapy on Soft and Hard Tissue Healing After Impacted Mandibular Third Molar Extraction

NCT07190950 | Recruiting

• 1 other identifier: 24368-ĐHYD
• Study Type: interventional
• Target: 22
• Locations: 1 country
• Sites: 1

Brief Summary

Impacted lower third molar extraction is one of the most commonly performed dental procedures in daily practice. However, this is considered a relatively invasive procedure. During the surgery, dental surgeon must reflect a full-thickness flap, remove bone to expose the tooth, section and deliver the tooth. As a result, after surgery, patients often experience many complications, from swelling, pain, jaw tightness, etc. to alveolar bone loss, periodontal problems distal to the second molar, etc. Therefore, clinicians are always looking for additional therapies to minimize complications, helping patients have a more comfortable experience after wisdom tooth surgery. To date, placing grafting materials such as bone or other biological materials (growth factors, platelet-rich plasma, platelet-rich fibrin) into the tooth socket has been shown to be able to preserve the alveolar crest after extraction. However, these materials require preparation time, are costly, and have the risk of infection related to bone grafts. Meanwhile, low-level laser therapy (LLLT) is known as a safe, non-invasive therapy that can affect cell metabolism without causing tissue damage. This therapy has been widely applied in many fields of medicine in general and in dentistry in particular. Low-level lasers have been studied to help reduce swelling, pain, and jaw tightness after impacted lower wisdom teeth surgery. In vitro or in vivo studies evaluating the healing effect of low-level lasers have given very positive results. However, there is still a lack of scientific evidence to prove the healing effect of low-level lasers on human tooth extraction sockets. The study we conducted is a scientific study, in the field of Dentistry. This study aimed to evaluate the effectiveness of low-level laser on soft tissue and bone healing after surgical extraction of impacted lower third molars in a group of Vietnamese population.

Conditions

Third Molars Extraction; Low Level Laser Therapy; Bone Healing

Outcome Measures

Primary Outcomes (3)

• wound healing score

  Base on IPR scale (Inflammatory Proliferative Remodeling Scale) by Hamzani et al. (2018)

  at third, seventh and thirtieth day after third molar extraction surgery

• New bone density

  Based on periapical X-rays taken on the day of surgery right after extraction, first and third month, we calculate new bone density by calculate the pixel density at extracted socket.

  The day of surgery, first and third month after surgery

• Changing of alveolar crest level distal to second lower molar

  After taking periapical X-rays on the day of surgery right after extraction, first and third month, we measure alveolar crest level distal to second lower molar from the base of extracted socket to cemento-enamel junction (CEJ) of second molar (the reference is a 5 mm stainless steel straight wire buried in rubber impression)

  the day of surgery, first and third month after third molar extraction surgery

Study Arms (2)

Control arm

NO INTERVENTION

After had third molar extraction at one side, patients do not receive low level laser therapy at this site (by not activating the tip)

Experiment arm

EXPERIMENTAL

After had third molar extraction at the other side, patients receive 7 sessions of low level laser therapy at this side (the day of surgery, then first day, third day, seventh day, fourteenth day, twenty first day, twenty eighth day after surgery)

Procedure: Low Level Laser Therapy

Interventions

Low Level Laser Therapy PROCEDURE

Patients will receive LLLT at one side after third molar extraction surgery. There will be 7 sessions at the day of surgery, then first, third, seventh, fourteenth, twenty first, twenty eighth day after surgery.

Also known as: LLLT

Experiment arm

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Healthy patients (at least 18 years of age) have both jaws lower impacted third molars indicated to be extracted. Both teeth are the same of

Sponsors & Collaborators

• University of Medicine and Pharmacy at Ho Chi Minh City: lead

Study Sites (1)

University of medicine and pharmacy at Ho Chi Minh city

Ho Chi Minh City, 7000000, Vietnam

RECRUITING

MeSH Terms

Interventions

Low-Level Light Therapy

Intervention Hierarchy (Ancestors)

Laser Therapy; Therapeutics; Phototherapy

Study Officials

• Ly Thi Bich Nguyen, Doctor of Philosophy

  STUDY DIRECTOR

Central Study Contacts

Hiep Hoang Ngoc Nguyen, Doctor of Dental Surgery

CONTACT

(+84) 848080298; nhnhiep.nt22@ump.edu.vn

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, INVESTIGATOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: DDS. Nguyen Hoang Ngoc Hiep

Study Record Dates

• First Submitted: September 17, 2025
• First Posted: September 24, 2025
• Study Start: August 30, 2024
• Primary Completion: August 30, 2025
• Study Completion: December 31, 2025
• Last Updated: November 28, 2025

Record last verified: 2025-09

Locations

VN (1)