NCT07757984

Brief Summary

The goal of this observational study is to learn about the impact of sarcopenia (muscle loss) on the efficacy of regional nerve blocks and postoperative recovery in patients undergoing upper extremity surgery. The main questions it aims to answer are:

  1. 1.Does sarcopenia affect the onset time and success rate of peripheral nerve blocks?
  2. 2.How does sarcopenia influence postoperative pain control and opioid consumption compared to patients receiving pure general anesthesia?

Trial Health

63
Monitor

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
150

participants targeted

Target at P50-P75 for all trials

Timeline
24mo left

Started Sep 2026

Geographic Reach
1 country

1 active site

Status
not yet recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

July 24, 2026

Completed
18 days until next milestone

First Posted

Study publicly available on registry

August 11, 2026

Completed
21 days until next milestone

Study Start

First participant enrolled

September 1, 2026

Expected
2 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

August 31, 2028

Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

August 31, 2028

Last Updated

August 11, 2026

Status Verified

July 1, 2026

Enrollment Period

2 years

First QC Date

July 24, 2026

Last Update Submit

August 6, 2026

Conditions

SarcopeniaNerve Block

Outcome Measures

Primary Outcomes (1)

  • time to first rescue analgesia

    From the completion of surgery up to Postoperative Day 2

Secondary Outcomes (8)

  • Nerve block onset

    From the completion of local anesthetic injection up to 30 minutes

  • Nerve block duration

    From the successful onset of sensory block to the patient's first report of pain at the surgical site, assessed up to postoperatively day 2

  • Intraoperative Mean Arterial Pressure (MAP) and Heart Rate (HR)

    During surgery (From the induction of anesthesia to the end of surgery, an average of 2 hours)

  • Postoperative NRSFrom the end of surgery up to 48 hours postoperatively.

    From the end of surgery up to postoperative day 2

  • Total opioid consumption

    From the end of surgery up to postoperative day 2

  • +3 more secondary outcomes

Study Arms (3)

General anesthesia alone

Other: sarcopeniaOther: Non-sarcopeniaProcedure: General Anesthesia

General anesthesia combine infraclavicular brachial plexus block, with sarcopenia

Other: sarcopeniaProcedure: General AnesthesiaProcedure: Nerve Block

General anesthesia combine infraclavicular brachial plexus block, without sarcopenia

Other: Non-sarcopeniaProcedure: General AnesthesiaProcedure: Nerve Block

Interventions

sarcopeniaOTHER

Patients identified with sarcopenia based on preoperative muscle assessment.

General anesthesia aloneGeneral anesthesia combine infraclavicular brachial plexus block, with sarcopenia
Non-sarcopeniaOTHER

Patients with normal muscle mass based on preoperative muscle assessment.

General anesthesia aloneGeneral anesthesia combine infraclavicular brachial plexus block, without sarcopenia
General AnesthesiaPROCEDURE

received general anesthesia alone

General anesthesia aloneGeneral anesthesia combine infraclavicular brachial plexus block, with sarcopeniaGeneral anesthesia combine infraclavicular brachial plexus block, without sarcopenia
Nerve BlockPROCEDURE

general anesthesia combined with nerve block

General anesthesia combine infraclavicular brachial plexus block, with sarcopeniaGeneral anesthesia combine infraclavicular brachial plexus block, without sarcopenia

Eligibility Criteria

Age50 Years+
Sexall
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

The study population comprises patients aged 50 years and older with an American Society of Anesthesiologists (ASA) physical status of I to III, who are scheduled to undergo upper extremity surgery under general anesthesia. Eligible participants must be capable of cooperating with postoperative pain and functional assessments.

You may qualify if:

  • Age\>=50 years old
  • ASA I-III
  • Receiving upper limb surgery under general anesthesia

You may not qualify if:

  • Severe cognitive impairment or inability to cooperate with pain and motor assessment
  • Pre-existing neuropathy of the musculocutaneous, median, radial or ulnar nerve
  • (for nerve block group) Contraindications to regional nerve blockade

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

ChangGung Memorial Hospital

Taoyuan, Taiwan

Location

MeSH Terms

Conditions

Sarcopenia

Interventions

Anesthesia, GeneralNerve Block

Condition Hierarchy (Ancestors)

Muscular AtrophyNeuromuscular ManifestationsNeurologic ManifestationsNervous System DiseasesAtrophyPathological Conditions, AnatomicalPathological Conditions, Signs and SymptomsSigns and Symptoms

Intervention Hierarchy (Ancestors)

AnesthesiaAnesthesia and AnalgesiaAnesthesia, ConductionDenervationNeurosurgical ProceduresSurgical Procedures, Operative

Study Officials

  • Tsai

    Chang Gung Memorial Hospital

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Yi Ting Chen

CONTACT

+886 965853825cheneating23@gmail.com

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

July 24, 2026

First Posted

August 11, 2026

Study Start (Estimated)

September 1, 2026

Primary Completion (Estimated)

August 31, 2028

Study Completion (Estimated)

August 31, 2028

Last Updated

August 11, 2026

Record last verified: 2026-07

Locations

TW(1)