Opioid-Free Pain Management After NUSS Surgery in Adolescents

NCT07288424 | Completed

• 1 other identifier: TJ-IRB202509077
• Study Type: observational
• Target: 17
• Locations: 1 country
• Sites: 1

Brief Summary

The investigators applied ultrasound-guided bilateral transverse thoracic fascia block combined with intercostal nerve block-a previously unreported analgesic approach for post-thoracic surgery-to NUSS patients. These suggest that ultrasound-guided transverse thoracic fascia combined with intercostal nerve block, in conjunction with bupivacaine liposome (72-hour analgesic duration), holds promise for a clinically feasible opioid-free analgesic regimen for severe post-NUSS pain.

Conditions

Nerve Block

Keywords

Nerve Block

Outcome Measures

Primary Outcomes (1)

• Pain score

  Pain was assessed every 2 hours within 12 hours postoperatively (upon admission to the PACU, 2 hours, 4 hours, 6 hours, and 12 hours postoperatively) and every 4 hours from 12 to 72 hours postoperatively. Pain scores were recorded at each time point using a Visual Analogue Scale (VAS).

  72 hours

Study Arms (2)

Experimental group

Patients who underwent ultrasound-guided bilateral transverse thoracic fascia block and intercostal nerve block after general anesthesia induction but before surgery.

Procedure: Nerve block

Control group

Patients who received incision local infiltration, serratus anterior plane block, intercostal nerve block, and erector spinae plane block.

Interventions

Nerve block PROCEDURE

Ultrasound-guided bilateral transverse thoracic fascia block and intercostal nerve block

Experimental group

Eligibility Criteria

• Age: 10 Years - 18 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

This study enrolled children and adolescents who underwent the NUSS procedure for pectus excavatum at the Department of Thoracic Surgery, Tongji Hospital, from June to September 2025. The inclusion criterion was age between 8 and 18 years.

You may qualify if:

• Adolescents who underwent the NUSS procedure.
• Adolescents who were between 8 and 18 years .

You may not qualify if:

• Adolescents who received epidural analgesia.
• Adolescents who received bilateral paravertebral nerve blocks.

Sponsors & Collaborators

• Qin Zhang: lead

Study Sites (1)

Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology

Wuhan, Hubei, 430030, China

Location

MeSH Terms

Interventions

Nerve Block

Intervention Hierarchy (Ancestors)

Anesthesia, Conduction; Anesthesia; Anesthesia and Analgesia; Denervation; Neurosurgical Procedures; Surgical Procedures, Operative

Study Officials

• Qin Zhang, phd

  Tongji Hospital

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: November 23, 2025
• First Posted: December 17, 2025
• Study Start: June 1, 2025
• Primary Completion: September 30, 2025
• Study Completion: September 30, 2025
• Last Updated: December 17, 2025

Record last verified: 2025-12

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)