Fructose and (Aging)

NCT07757347 | Recruiting

• 1 other identifier: UVienna25
• Study Type: interventional
• Target: 32
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of the present study is to investigate the effect of fructose consumption on health parameters and the intestinal barrier in healthy individuals

Conditions

Intestinal Permeability; Immune Response

Outcome Measures

Primary Outcomes (2)

• Changes in markers of intestinal permeability

  Changes in concentrations of bacterial endotoxin in blood plasma

  At the end of the treatment (1 month)

• Cytokine release from blood immune cells stimulated with bacterial toxins

  Changes in cytokine concentration in supernatant of immune cells before and after the treatments

  At the end of the treatment (1 month)

Study Arms (2)

Fructose

EXPERIMENTAL

Following a standardization of their nutritional intake for three days, participants will receive a drink supplemented with free fructose.

Other: Fructose

Glucose

EXPERIMENTAL

Following a standardization of their nutritional intake for three days, participants will receive a drink supplemented with free glucose.

Other: Glucose

Interventions

Fructose OTHER

Following a standardization of their nutritional intake for three days, participants will either receive a drink supplemented with low doses of free fructose (5%).

Also known as: Diet

Fructose

Glucose OTHER

Following a standardization of their nutritional intake for three days, participants will either receive a drink supplemented with low doses of free glucose (5 %).

Also known as: Diet

Glucose

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• all gender, healthy collective ≥ 18 years old

You may not qualify if:

• Chronic inflammatory diseases of the gastrointestinal tract
• Metabolic diseases or taking medication to treat metabolic diseases
• Fructose malabsorption
• Hereditary fructose intolerance
• Food intolerances and/or allergies, as well as food allergies that require special dietary interventions
• Special diets, such as vegetarian/vegan diets
• Unstable body weight within the last 6 months (fluctuations of \> 5%)
• BMI \< 19 kg/m2 \& \> 29,9 kg/m2
• Bariatric surgery
• Smoking
• Liver diseases
• Renal insufficiency
• Rheumatoid arthritis
• COPD with ≥ 2 exacerbations per year
• Chronic pancreatitis or recurrent acute pancreatitis

Sponsors & Collaborators

• University of Vienna: lead

Study Sites (1)

University of Vienna

Vienna, 1090, Austria

RECRUITING

MeSH Terms

Interventions

Fructose; Diet; Glucose

Intervention Hierarchy (Ancestors)

Hexoses; Monosaccharides; Sugars; Carbohydrates; Ketoses; Nutritional Physiological Phenomena; Diet, Food, and Nutrition; Physiological Phenomena

Central Study Contacts

Ina Bergheim, Prof.

CONTACT

+43-1-4277-54981; ina.bergheim@univie.ac.at

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: BASIC SCIENCE
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Prof. Dr.

Study Record Dates

• First Submitted: April 30, 2026
• First Posted: August 11, 2026
• Study Start: April 1, 2026
• Primary Completion (Estimated): July 1, 2027
• Study Completion (Estimated): December 1, 2027
• Last Updated: August 11, 2026

Record last verified: 2026-04

Locations

AU (1)