The Effects of a Multicomponent Sleep & Recovery Supplement on Muscle Fatigue and Sleep

NCT07756164 | Not Yet Recruiting

• 1 other identifier: 8096200
• Study Type: interventional
• Target: 25
• Locations: 0 countries
• Sites: N/A

Brief Summary

The goal of this clinical trial (randomised crossover study) is to learn if a multi-component sleep and exercise recovery supplement can improve sleep quality and enhance recovery following exercise in healthy, recreationally active adults aged 18-40. The main questions it aims to answer are:

• Take the supplement during one 2-week period and the placebo during another (order randomised), 30 minutes before bed each day
• Complete an exercise protocol involving repeated leg extensions designed to induce muscle fatigue
• Attend six laboratory visits, including baseline testing and follow-up assessments at 24 and 48 hours post-exercise
• Complete daily sleep questionnaires during each supplementation period
• Record food intake prior to exercise trials and replicate it for consistency
• Perform muscle soreness assessments and single-leg jump tests before and after exercise, and during recovery

Conditions

Athletes; Healthy

Keywords

Muscle Damage; Sleep; Supplementation; Recovery

Outcome Measures

Primary Outcomes (5)

• Changes in total work done

  Changes in total work done as measured by the Biodex

  Following each 2-week supplementation period of either supplement

• Changes in work done (Flexion)

  Changes in work done (Flexion) as measured by the Biodex

  Following each 2-week supplementation period of either supplement

• Changes in work done (Extension)

  Changes in work done (Extension) as measured by the Biodex

  Following each 2-week supplementation period of either supplement

• Changes in Single Leg jump height

  Changes in Single Leg jump height (m)

  Before and Immediately After Muscle Damaging Protocol at the End of Each 2-Week Supplementation Period

• Changes in Single Leg Jump hang time

  Changes in Single Leg Jump hang time (s)

  Before and Immediately After Muscle Damaging Protocol at the End of Each 2-Week Supplementation Period

Secondary Outcomes (6)

• Changes in sleep quality

  Following each 2-week supplementation period of either supplement.

• Changes in perceived muscle soreness (Pain pressure threshold)

  Following each 2-week supplementation period of either supplement and 24hr and 48hr following the muscle damaging protocol.

• Change in Self-Reported Readiness to Train Score (5-Point Likert Scale)

  Following each 2-week supplementation period of either supplement and 24hr and 48hr following the muscle damaging protocol

• Changes in Sleep Quality

  Following each 2-week supplementation period of either supplement.

• Change in perceived recovery status (10-Point Likert Scale)

  Following each 2-week supplementation period of either supplement and 24hr and 48hr following the muscle damaging protocol

Study Arms (2)

Magnesium-based sleep & recovery supplementation

EXPERIMENTAL

Supplementation of a magnesium-based sleep \& recovery supplement (2g/day for 2-weeks)

Dietary Supplement: magnesium-based sleep & recovery supplement

Placebo Supplementation

PLACEBO COMPARATOR

Supplementation of placebo (2g/day for 2-weeks)

Dietary Supplement: Placebo Supplementation

Interventions

magnesium-based sleep & recovery supplement DIETARY_SUPPLEMENT

magnesium-based sleep \& recovery supplement (2g/day for 2-weeks)

Magnesium-based sleep & recovery supplementation

Placebo Supplementation DIETARY_SUPPLEMENT

Placebo Supplementation (2g/day for 2-weeks)

Placebo Supplementation

Eligibility Criteria

• Age: 18 Years - 40 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Aged between 18-40, healthy and non smokers
• Recreationally active, exercise at least 2 times a week

You may not qualify if:

• Not have any injuries that would affect performance
• Not taking any medications that could affect drowsiness or energy levels
• Not taking any other dietary supplements high in magnesium
• Not be pregnant
• Not have any illness or medical condition that could make intense exercise unsafe
• Not be participating in other studies that could interfere with the outcomes of this study
• Not have any current sleep problems e.g. Insomnia

Sponsors & Collaborators

• University of Exeter: lead

Central Study Contacts

Tom G Gurney, PhD

CONTACT

+44 (0) 1326 370400; t.g.gurney@exeter.ac.uk

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, INVESTIGATOR
• Purpose: TREATMENT
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: April 16, 2026
• First Posted: August 10, 2026
• Study Start: August 1, 2026
• Primary Completion (Estimated): October 1, 2026
• Study Completion (Estimated): December 1, 2026
• Last Updated: August 10, 2026

Record last verified: 2026-08

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL, SAP, ICF