Effect of a Nutritional Supplement on Muscle Recovery

NCT07586839 | Recruiting

• 1 other identifier: NL88300.028.24
• Study Type: interventional
• Target: 28
• Locations: 1 country
• Sites: 1

Brief Summary

The aim is to develop a food supplement drink that supports muscle health by combining specific fatty acids, which can positively affect metabolic and inflammation processes that are important for muscle health.

Conditions

Healthy

Outcome Measures

Primary Outcomes (1)

• Change in isometric muscle strength of the vastus lateralis muscle on a muscle dynamometer before and 72h after damaging exercise

  The main study endpoint is the change in skeletal muscle function recovery from a single bout of damaging eccentric exercise between an emulsion containing caprylic acid and omega 3 fatty acids, compared to a control emulsion, from before exercise (t=0) to 72 hours post-exercise. Skeletal muscle function will be measured as maximal voluntary isometric muscle strength of the vastus lateralis muscle on a muscle dynamometer. The maximal voluntary strength is expressed as maximal voluntary contraction (Newtons).

  The change in muscle strength will be measured at time points 0 hours (before exercise), and post exercise, and at 24 hours, 48 hours and 72 hours post exercise.

Secondary Outcomes (6)

• Change in muscle fatigue from before until 72 hours after damaging exercise measured with electrical stimulation on a muscle dynamometer

  The change in fatigue resistance will be measured at time points 0 hours (before exercise), and post exercise, and at 24 hours, 48 hours and 72 hours post exercise.

• Change in muscle soreness from before until up to 72 hours after a damaging exercise using a VAS-Scale and soreness questionnaire

  The change in muscle soreness will be measured at time points 0 hours (before exercise), and post exercise, and at 24 hours, 48 hours and 72 hours post exercise.

• Plasma creatine kinase concentrations before and up to 72 hours after damaging exercise in blood

  The change in plasma creatine kinase will be measured at time points 0 hours (before exercise), and post exercise, and at 24 hours, 48 hours and 72 hours post exercise.

• Plasma cholesterol concentrations before and up to 72 hours after damaging exercise in blood

  The change in plasma cholesterol concentrations will be measured at time points 0 hours (before exercise), and post exercise, and at 24 hours, 48 hours and 72 hours post exercise.

• Plasma triglyceride concentrations before and up to 72 hours after damaging exercise in blood

  The change in plasma triglycerides will be measured at time points 0 hours (before exercise), and post exercise, and at 24 hours, 48 hours and 72 hours post exercise.

Study Arms (2)

Testdrink

EXPERIMENTAL

Drink containing caprylic acid and omega-3 fatty acids

Dietary Supplement: Vegan supplement containing caprylic acid and omega-3 fatty acids

Control drink

PLACEBO COMPARATOR

Control drink that differs in fatty acid composition

Dietary Supplement: Control drink

Interventions

Control drink DIETARY_SUPPLEMENT

Seven day supplementation with a muscle damaging exercise performed on day four

Control drink

Vegan supplement containing caprylic acid and omega-3 fatty acids DIETARY_SUPPLEMENT

Seven day supplementation with a muscle damaging exercise performed on day four

Testdrink

Eligibility Criteria

• Age: 18 Years - 35 Years
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Young (≥18 and ≤35 years)
• Male sex
• Non-obese (≥18.5 and ≤27.5 kg/m2)
• Recreationally active (performing non-competitive exercise at least one time a week for minimally 30 minutes)

You may not qualify if:

• Smoking
• Participation in structural exercise with a major eccentric component (e.g. soccer, basketball, trail running, etc…)
• Chronic use of any prescribed over the counter pharmaceuticals
• Any history of medical or surgical events that may effect the study outcomes
• Following a specific diet (e.g. weight loss, ketogenic, vegan)
• Taking protein supplements

Sponsors & Collaborators

• Wageningen University: lead

Study Sites (1)

Wageningen University and Research

Wageningen, Gelderland, 6708WD, Netherlands

RECRUITING

MeSH Terms

Interventions

Fatty Acids, Omega-3

Intervention Hierarchy (Ancestors)

Dietary Fats, Unsaturated; Dietary Fats; Fats; Lipids; Fatty Acids, Unsaturated; Fatty Acids; Fish Oils; Oils

Central Study Contacts

Silvie Timmers, PhD

CONTACT

+31 317-484 136; silvie.timmers@wur.nl

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: OTHER
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Dr.

Study Record Dates

• First Submitted: February 21, 2025
• First Posted: May 14, 2026
• Study Start: September 26, 2025
• Primary Completion (Estimated): June 1, 2026
• Study Completion (Estimated): September 1, 2026
• Last Updated: May 14, 2026

Record last verified: 2026-04

Locations

NL (1)