Strength Training Combined With Blood Flow Restriction and Cerebral Palsy

NCT07748052 | Not Yet Recruiting

• 1 other identifier: No.P.T.REC/012/005093
• Study Type: interventional
• Target: 26
• Locations: 0 countries
• Sites: N/A

Brief Summary

load resistance exercises are performed while partially restricting venous blood flow to the exercising limb using a pneumatic cuff. In children with hemiplegic cerebral palsy, this intervention has been proposed to enhance muscle strength and hypertrophy while minimizing mechanical stress on joints and soft tissues. Previous studies suggest that BFR training may improve muscle thickness, muscle strength, functional mobility, gait performance, and overall physical function compared with conventional low-intensity strength training alone. However, careful monitoring of cuff pressure, exercise intensity, and safety considerations is essential when applying this technique in pediatric populations.

Conditions

Cerebral Palsy

Keywords

cerebral palsy; progressive resistive exercise; low load resistive training; blood flow restriction

Outcome Measures

Primary Outcomes (2)

• ultrasonography for measuring muscle thickness

  6 weeks

• quality of upper-extremity skills test for measuring upper limb function

  6 weeks

Study Arms (2)

strength training combined with blood flow restriction and designed physical therapy program

EXPERIMENTAL

Other: strength training combined with blood flow restriction and designed physical therapy program

designed physical therapy program

EXPERIMENTAL

Other: a specially designed physical therapy program

Interventions

strength training combined with blood flow restriction and designed physical therapy program OTHER

A specially designed physical therapy program in addition to progressive resistive exercises for 60 min (30 min designed P.T program and other 30 min for progressive resistive exercise with blood flow restriction ), 3 sessions/ week for 6 successive weeks. strengthening exercise for shoulder flexors, abductors and external rotators, elbow flexors and extensors will be applied with low load while blood flow restriction is applied proximal to the limb

strength training combined with blood flow restriction and designed physical therapy program

a specially designed physical therapy program OTHER

conventional physical therapy program including reinforcement of the normal motor development, reflex inhibiting patterns, postural reaction, stretching, strengthening exercises, and gait training was applied to children in the control group

designed physical therapy program

Eligibility Criteria

• Age: 4 Years - 10 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17)

You may qualify if:

• A diagnosis of spastic hemiplegic CP
• Degree of spasticity ranges from 1+ and 2, according to modified Ashworth scale (MAS)
• The age of the selected children will range from 4 to 6 years old.
• Children are levels II and III according to GMFCS

You may not qualify if:

• Children with visual or auditory problems. 2. Children with severe intellectual disability (IQ less than 65 according to Stanford Binet intelligence scale).

Sponsors & Collaborators

• Cairo University: lead

MeSH Terms

Conditions

Cerebral Palsy

Condition Hierarchy (Ancestors)

Brain Damage, Chronic; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases

Central Study Contacts

Alaa Alnemr

CONTACT

+201003727467; alaaalnemr28@gmail.com

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: assistant professor at faculty of physical therapy, cairo university

Study Record Dates

• First Submitted: July 30, 2026
• First Posted: August 5, 2026
• Study Start: August 6, 2026
• Primary Completion (Estimated): February 1, 2027
• Study Completion (Estimated): July 11, 2027
• Last Updated: August 5, 2026

Record last verified: 2026-08

Data Sharing

• IPD Sharing: Will not share