Effects of Exercise Prior to Radical Prostatectomy

NCT07746414 | Not Yet Recruiting

• 1 other identifier: 2000041449
• Study Type: interventional
• Target: 20
• Locations: 1 country
• Sites: 1

Brief Summary

This pilot study will explore the metabolic and psychological effects of High-Intensity Interval Training (HIIT) exercise as well as its impact on patient recovery from radical prostatectomy.

Conditions

Recovery; Post Prostatectomy

Keywords

High-Intensity Interval Training (HIIT)

Outcome Measures

Primary Outcomes (1)

• Mean concentration N-lactoyl phenylalanine

  Mean concentration N-lactoyl phenylalanine (pg/ml) in blood

  Pre-exercise (Baseline) and post-excercise (4 weeks)

Secondary Outcomes (5)

• Mean score Memorial Anxiety Scale for Prostate Cancer (MAXPC)

  Pre-exercise (Baseline) and post-exercise (4 weeks)

• Mean score Expanded Prostate Cancer Index Composite Short Form (EPIC-26)

  Pre-exercise (Baseline) and post-exercise (4 weeks)

• Percentage of participants that used opioids

  Post operative (Day 1)

• Percentage of participants readmitted

  Post operative (Day 1) up to 12 weeks

• Mean number ER visits

  Post operative (Day 1) up to 12 weeks

Study Arms (1)

Radical prostatectomy + High-Intensity Interval Training (HIIT)

EXPERIMENTAL

Participants who undergo radical prostatectomy will perform HIIT exercise regimen for a minimum of four weeks prior to prostatectomy under the supervision of a physical therapist or exercise physiologist.

Behavioral: High-intensity interval training (HIIT) exercise

Interventions

High-intensity interval training (HIIT) exercise BEHAVIORAL

The intervention will consist of vigorous physical activity for a goal of 60 minutes each week for a minimum of four weeks prior to prostatectomy.

Radical prostatectomy + High-Intensity Interval Training (HIIT)

Eligibility Criteria

• Age: 35 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Scheduled or intended treatment with radical prostatectomy at Yale New Haven Hospital
• English language fluency
• Clinically localized low, intermediate or high risk by National Comprehensive Cancer Network (NCCN) criteria
• Able to attend 2 in person exercise training sessions per week for four-six weeks

You may not qualify if:

• Treatment with non-surgical modality
• Prior therapy for prostate cancer (e.g. radiation therapy or focal therapy)
• Already engaged in regular exercise (\>60 minutes per week)
• Unstable cardiovascular disease
• Physical mobility limitation, unable to walk or exercise
• Locally advanced (cT4 or cN1 or cM1) prostate cancer
• Prior treatment with androgen deprivation therapy

Sponsors & Collaborators

• Yale University: lead

Study Sites (1)

Yale New Haven Hospital

New Haven, Connecticut, 06520, United States

Location

MeSH Terms

Interventions

High-Intensity Interval Training; Exercise

Intervention Hierarchy (Ancestors)

Physical Conditioning, Human; Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Officials

• Michael Leapman, MD

  Yale University

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Sarah Linsky, MPH

CONTACT

475-375-6129; sarah.linsky@yale.edu

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: SUPPORTIVE CARE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: July 29, 2026
• First Posted: August 5, 2026
• Study Start: August 1, 2026
• Primary Completion (Estimated): August 1, 2027
• Study Completion (Estimated): August 1, 2027
• Last Updated: August 7, 2026

Record last verified: 2026-07

Data Sharing

• IPD Sharing: Will share

Locations

US (1)