Influence of Specific Collagen Peptides on Recovery After Exercise Induced Muscle Damage

NCT05220371 | Completed

• 1 other identifier: 00765
• Study Type: interventional
• Target: 50
• Locations: 1 country
• Sites: 1

Brief Summary

The present study aims at investigating the potential influence of specific collagen peptides on recovery after exercise induced muscle damage with focus on long-term effects.

Conditions

Recovery

Keywords

Collagen peptides; Concurrent training; Ultrasound; MVC; RFD

Outcome Measures

Primary Outcomes (10)

• Change in maximal voluntary contraction (MVC)

  Measured by isokinetic dynamometer

  Baseline (pre, post, 24 hours, 48 hours) and after 12 weeks (pre, post, 24 hours, 48 hours)

• Change in rate of force development (RFD)

  Measured by isokinetic dynamometer

  Baseline (pre, post, 24 hours, 48 hours) and after 12 weeks (pre, post, 24 hours, 48 hours)

• Change in countermovement jump height (CMJ)

  Measured by force plate

  Baseline (pre, post, 24 hours, 48 hours) and after 12 weeks (pre, post, 24 hours, 48 hours)

• Change in subjective pain score

  Measured by visual analogue scale

  Baseline (pre, post, 24 hours, 48 hours) and after 12 weeks (pre, post, 24 hours, 48 hours)

• Change in Achilles tendon cross-sectional area

  Measured by ultrasound

  Baseline and after 12 weeks

• Change in Vastus Lateralis fibre length

  Measured by ultrasound

  Baseline (pre, post, 24 hours, 48 hours) and after 12 weeks (pre, post, 24 hours, 48 hours)

• Change in collagen related blood markers

  Measured by blood analysis

  Baseline (pre, post, 2 hours, 24 hours, 48 hours) and after 12 weeks (pre, post, 2 hours, 24 hours, 48 hours)

• Change in Achilles tendon echo intensity

  Measured by ultrasound

  Baseline and after 12 weeks

• Change in Vastus Lateralis echo intensity

  Measured by ultrasound

  Baseline and after 12 weeks

• Change in body composition parameters (fat mass, fat-free mass, extracellular mass, body cell mass)

  Measured by bioelectrical impedance analysis

  Baseline and after 12 weeks

Study Arms (2)

Collagen

EXPERIMENTAL

15g of collagen peptides ingested daily

Dietary Supplement: Collagen; Other: Concurrent training

Placebo

PLACEBO COMPARATOR

15g of Placebo ingested daily

Other: Concurrent training

Interventions

Collagen DIETARY_SUPPLEMENT

Participants ingest 15 grams of either specific collagen peptides or Placebo daily

Collagen

Concurrent training OTHER

Both arms undergo a 12-week trainingintervention 3x/week

Collagen; Placebo

Eligibility Criteria

• Age: 18 Years - 40 Years
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• No subjective symptoms during physical exertion
• Stable weight and dietary behaviour
• Body Mass Index (BMI) between 18.5 and 24.9
• No extensive strength/endurance sports so far (less than 3 h/week)
• No complaints during strenuous physical activity

You may not qualify if:

• Circumstances that impair/prevent sporting activity (e.g. chronic heart disease, arrhythmia, heart valve disease, arthritis etc.)
• Intolerance/aversion to animal protein
• Arterial hypertension (high blood pressure) (syst \> 200 mmHg and/or diast \> 105 mmHg) at rest
• Presence of insulin-dependent diabetes mellitus
• Liver and/or kidney disease that precludes a high protein load
• Collagen supplementation or regular intake of other dietary supplements in the last 6 months.

Sponsors & Collaborators

• University of Vienna: lead
• CRI Collagen Research Institute GmbH: collaborator

Study Sites (1)

University of Vienna, Institute of Sport Science

Vienna, 1150, Austria

Location

Related Publications (2)

• Bischof K, Stafilidis S, Bundschuh L, Oesser S, Baca A, Konig D. Reduction in systemic muscle stress markers after exercise-induced muscle damage following concurrent training and supplementation with specific collagen peptides - a randomized controlled trial. Front Nutr. 2024 Mar 25;11:1384112. doi: 10.3389/fnut.2024.1384112. eCollection 2024.

  PMID: 38590831 DERIVED

• Bischof K, Stafilidis S, Bundschuh L, Oesser S, Baca A, Konig D. Influence of specific collagen peptides and 12-week concurrent training on recovery-related biomechanical characteristics following exercise-induced muscle damage-A randomized controlled trial. Front Nutr. 2023 Nov 16;10:1266056. doi: 10.3389/fnut.2023.1266056. eCollection 2023.

  PMID: 38035363 DERIVED

MeSH Terms

Interventions

Collagen

Intervention Hierarchy (Ancestors)

Biopolymers; Polymers; Macromolecular Substances; Extracellular Matrix Proteins; Scleroproteins; Proteins; Amino Acids, Peptides, and Proteins

Study Officials

• Daniel Koenig, Prof. Dr.

  University of Vienna, Institute of Sport Science

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, INVESTIGATOR
• Masking Details: Double-blind, randomized controlled trial
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Univ.-Prof. Dr. med. Daniel König

Study Record Dates

• First Submitted: January 28, 2022
• First Posted: February 2, 2022
• Study Start: January 28, 2022
• Primary Completion: June 30, 2023
• Study Completion: June 30, 2023
• Last Updated: August 28, 2023

Record last verified: 2023-08

Data Sharing

• IPD Sharing: Will not share

Locations

AU (1)