Sequential Order of RSI on Tracheal Intubation

NCT07741578 | Completed

• 1 other identifier: ZKL-KY-2024-008
• Study Type: interventional
• Target: 380
• Locations: 1 country
• Sites: 1

Brief Summary

This clinical trial aims to understand the effect of the order of administration of Neuromuscular Blocking Agents (NMBAs) and sedatives on the success rate of intubation during Rapid Sequence Intubation (RSI) in the emergency department. The main questions to be answered include:

1. 1.The impact of sequential drug administration order during rapid sequence induction (RSI) on first-pass intubation success rates.
2. 2.Time to successful intubation
3. 3.Hypoxia incidence (SpO₂ \<90%)
4. 4.Risk of post-traumatic stress disorder (PTSD)
5. 5.Procedure-related complications

Conditions

Tracheal Intubation; Rapid Sequence Induction and Intubation

Outcome Measures

Primary Outcomes (1)

• First-pass success rate

  Successful intubation on the first attempt, confirmed by any one of: Direct visualization of the ETT passing through vocal cords Bilateral breath sounds on auscultation Fiberoptic bronchoscopic confirmation of tracheal placement Sustained end-tidal CO₂ waveform (EtCO₂ \>15 mmHg for ≥3 breaths)

  Perioperative

Secondary Outcomes (5)

• Time to intubation

  Perioperative

• Intubation recall

  From drug injection to Remove the endotracheal tube

• Changes in SBP

  Perioperative

• Changes in HR

  Perioperative

• Changes in SpO₂

  Perioperative

Study Arms (2)

Sedative to NMBA

NO INTERVENTION

Sedative(Propofol) →within 30s→ NMBA(Rocuronium) → Intubation

NMBA to Sedative

EXPERIMENTAL

NMBA(Rocuronium) →within 30s→ Sedative(Propofol) → Intubation

Procedure: Drug Sequence

Interventions

Drug Sequence PROCEDURE

Control: Sedative ( Propofol ) →within 30s→ NMBA ( Rocuronium ) → Intubation → 5min → Measure vital signs → After treatment → Remove tracheal intubation→ Recall of intubation Intervention: NMBA ( Rocuronium ) →within 30s→ Sedative(Propofol) → Intubation → 5min → Measure vital signs → After treatment → Remove tracheal intubation→ Recall of intubation

NMBA to Sedative

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• in ED/EICU required emergency intubation
• RSI required

You may not qualify if:

• Pregnancy
• do not intubation orders
• Declined participation
• Other trials
• Non-emergent cases
• Active CPR

Sponsors & Collaborators

• Zhongnan Hospital: lead

Study Sites (1)

Zhongnan Hospital of Wuhan University

Wuhan, China

Location

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: OTHER
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: July 23, 2026
• First Posted: August 3, 2026
• Study Start: July 1, 2025
• Primary Completion: June 1, 2026
• Study Completion: June 30, 2026
• Last Updated: August 3, 2026

Record last verified: 2026-07

Locations

CN (1)