A Clinical Trial to Evaluate the Effects of a Supplement on Markers of Male Fertility

NCT07740161 | Completed

• 2 other identifiers: 20728legacy-20728
• Study Type: interventional
• Target: 40
• Locations: 1 country
• Sites: 1

Brief Summary

This study will evaluate the effects of the WeNatal For Him supplement on markers of male fertility over a 3-month period. The trial is a single-arm, unblinded study enrolling 40 male participants who will take 3 capsules of the test product daily in the morning with their first meal. Participants will complete questionnaires at Baseline, Month 1, Month 2, and Month 3. Semen analysis will be conducted at home at Baseline and Month 3, and blood testing will be performed at a local Labcorp location at Baseline and Month 3. The primary focus is on sperm quality parameters and testosterone levels, while secondary endpoints capture participants' perceptions of changes in reproductive and sexual health, including energy and libido.

Conditions

Male Infertility; Low Sperm Quality; Low Testosterone; Low Energy; Low Libido

Outcome Measures

Primary Outcomes (10)

• Change in Testosterone (Free and Total)

  Assessed via blood test at a local Labcorp location measuring free and total testosterone levels

  Baseline and Month 3

• Change in Sperm Volume

  Assessed via at-home semen analysis using the Fellow Semen Analysis kit

  Baseline and Month 3

• Change in Sperm Concentration

  Assessed via at-home semen analysis using the Fellow Semen Analysis kit

  Baseline and Month 3

• Change in Sperm Count

  Assessed via at-home semen analysis using the Fellow Semen Analysis kit

  Baseline and Month 3

• Change in Sperm Motility

  Assessed via at-home semen analysis using the Fellow Semen Analysis kit

  Baseline and Month 3

• Change in Total Motile Count

  Assessed via at-home semen analysis using the Fellow Semen Analysis kit

  Baseline and Month 3

• Change in Sperm Morphology

  Assessed via at-home semen analysis using the Fellow Semen Analysis kit

  Baseline and Month 3

• Change in 25-hydroxy Vitamin D

  Assessed via blood test at a local Labcorp location

  Baseline and Month 3

• Change in hs-CRP

  Assessed via blood test at a local Labcorp location

  Baseline and Month 3

• Change in Homocysteine

  Assessed via blood test at a local Labcorp location

  Baseline and Month 3

Secondary Outcomes (3)

• Change in Self-Reported Reproductive Health

  Baseline, Month 1, Month 2, and Month 3

• Change in Self-Reported Energy

  Baseline, Month 1, Month 2, and Month 3

• Change in Self-Reported Libido

  Baseline, Month 1, Month 2, and Month 3

Study Arms (1)

WeNatal For Him Supplement

EXPERIMENTAL

Dietary Supplement: WeNatal For Him Supplement

Interventions

WeNatal For Him Supplement DIETARY_SUPPLEMENT

All participants take 3 capsules of the WeNatal For Him supplement daily in the morning with their first meal for 3 months.

WeNatal For Him Supplement

Eligibility Criteria

• Age: 30 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Be male
• Be aged 30+
• Anyone currently experiencing issues regarding low energy and low libido
• Anyone who is generally healthy - does not live with any uncontrolled chronic disease
• Willing to stop taking any other products or prescription medication, herbal remedies, or supplements for the duration of the study that target fertility, reproductive health, and sexual health
• Not planning on introducing any products or any new prescription medication, herbal remedies, or supplements that target male fertility, reproductive health, or sexual health for the study duration
• Resides in the United States
• Not currently partaking in another research study and will not be partaking in any other research study for the next 3 months and at any point during this study's duration
• Willing to provide a semen sample via masturbation
• Willing to abstain from ejaculation for a minimum of 48 hours and a maximum of 5 days before providing the semen sample
• Willing to abstain from marijuana products during the entire study duration

You may not qualify if:

• Anyone with pre-existing chronic conditions that would prevent participants from adhering to the protocol, including oncological and psychiatric disorders
• Anyone who has ever taken supplemental testosterone
• Anyone planning to undergo any surgeries or invasive treatments for the study duration
• Anyone who has had a major illness in the last 3 months
• Anyone currently undergoing any type of fertility treatment
• Anyone with any allergies or sensitivities to any of the study product ingredients
• Anyone unwilling to follow the study protocol
• Anyone taking anticoagulant or 'blood thinner' medication
• Anyone undergoing chemotherapy
• Anyone taking insulin or diabetes medication
• Anyone who drinks heavily (i.e. 8 or more alcoholic drinks per week for women or 15 or more alcoholic drinks per week for men)
• Anyone with a history of substance abuse
• Anyone who is currently a smoker or has been a smoker in the past 3 months

Sponsors & Collaborators

• WeNatal: lead
• Citruslabs: collaborator

Study Sites (1)

Citruslabs

Las Vegas, Nevada, 89118, United States

Location

MeSH Terms

Conditions

Infertility, Male

Condition Hierarchy (Ancestors)

Genital Diseases, Male; Genital Diseases; Urogenital Diseases; Infertility; Male Urogenital Diseases

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: INDUSTRY
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: July 28, 2026
• First Posted: July 31, 2026
• Study Start: April 14, 2025
• Primary Completion: September 15, 2025
• Study Completion: September 15, 2025
• Last Updated: July 31, 2026

Record last verified: 2026-07

Locations

US (1)