Study the Effect of Plant-based Beverage Consumption on the Gut Microbiome in Healthy Adults

NCT07730229 | Recruiting

• 1 other identifier: Plant-based beverages
• Study Type: interventional
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this intervention study is to analyse the microbiota composition after the plant-based beverage consumption. The main questions are to evaluate if the plant-based beverage can have a beneficial effect on the gut microbiota. Participants will consume different plant-based beverages for two weeks, and microbiota will be analysed. Researchers will compare the microbiota composition before and after consumption.

Conditions

Plant-based Milk; Gastrointestinal Microbiome

Outcome Measures

Primary Outcomes (2)

• Change in gut microbiome alpha diversity

  Gut microbiome alpha diversity will be assessed using 16S rRNA gene sequencing and quantified using alpha diversity indices (e.g., Shannon diversity index).

  up to 24 weeks

• Change in gut microbiome beta diversity

  Gut microbiome beta diversity will be assessed using 16S rRNA gene sequencing by comparing community composition between samples using beta diversity distance metrics (e.g., Bray-Curtis dissimilarity or UniFrac distances).

  Upto 24 weeks

Secondary Outcomes (1)

• Change in the relative abundance of gut bacterial taxa

  Baseline to Week 24

Study Arms (2)

Active group

ACTIVE COMPARATOR

Participants will consume the assigned dairy milk for two weeks.

Dietary Supplement: plant-based beverage

Experimental group

EXPERIMENTAL

Participants will consume the assigned plant-based beverages for two weeks.

Dietary Supplement: plant-based beverage

Interventions

plant-based beverage DIETARY_SUPPLEMENT

Participants will consume the assigned plant-based beverages for two weeks.

Active group; Experimental group

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• \- 18-65 years of age. • must be able to complete the form digitally.

You may not qualify if:

• Must not be diagnosed with gastrointestinal diseases, autoimmune diseases or have diseases or medications that cause immune deficiency, such as MS, type 1 diabetes, cancer or HIV
• must not take antibiotics during the study period
• must not have a milk protein allergy

Sponsors & Collaborators

• Lund University: lead

Study Sites (1)

Lund University

Lund, Skåne County, 22100, Sweden

RECRUITING

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor

Study Record Dates

• First Submitted: June 29, 2026
• First Posted: July 28, 2026
• Study Start: November 10, 2025
• Primary Completion: July 30, 2026
• Study Completion: July 31, 2026
• Last Updated: July 28, 2026

Record last verified: 2026-07

Locations

SE (1)