Vascular Aging and Acute Kidney Injury After Cardiac Surgery

NCT07727772 | Not Yet Recruiting

• 1 other identifier: KY20260625-09
• Study Type: observational
• Target: 472
• Locations: 1 country
• Sites: 1

Brief Summary

This prospective observational cohort study will enroll adult patients undergoing cardiac surgery at Nanjing First Hospital, Nanjing Medical University. The study will evaluate multidimensional vascular aging markers before surgery and assess their association with postoperative acute kidney injury within 7 days after surgery. No intervention will be assigned by the study protocol, and all perioperative management will follow routine clinical practice.

Conditions

Acute Kidney Injury Cardiac Surgery; Postoperative Complications; Vascular Aging

Keywords

vascular aging; acute kidney injury; postoperative complications

Outcome Measures

Primary Outcomes (1)

• Incidence of Postoperative Acute Kidney Injury Within 7 Days After Surgery

  Postoperative acute kidney injury will be assessed within 7 days after surgery according to predefined diagnostic criteria based on postoperative renal function changes. The outcome will be recorded as the occurrence of acute kidney injury during the postoperative 7-day period.

  From the date of surgery to postoperative day 7

Secondary Outcomes (1)

• Severity of Postoperative Acute Kidney Injury

  From the date of surgery to postoperative day 7

Study Arms (1)

Cardiac Surgery Cohort

Adult patients undergoing cardiac surgery at Nanjing First Hospital who will receive perioperative vascular aging assessment and postoperative renal function monitoring according to the study protocol. No treatment or perioperative management strategy will be assigned by the study protocol.

Other: Multidimensional Vascular Aging Assessment

Interventions

Multidimensional Vascular Aging Assessment OTHER

Perioperative assessment of vascular aging-related indicators, including noninvasive vascular assessments, hemodynamic measurements, and relevant clinical and laboratory variables. The assessment is observational and will not determine the treatment, surgical procedure, or perioperative management assigned to participants.

Cardiac Surgery Cohort

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The study population will consist of adult patients undergoing cardiac surgery at Nanjing First Hospital, Nanjing Medical University. Eligible patients will receive perioperative vascular aging assessment and postoperative renal function monitoring according to the study protocol. Participants will be followed for postoperative acute kidney injury within 7 days after surgery.

You may qualify if:

• Adult patients aged 18 years or older.
• Patients scheduled to undergo cardiac surgery at Nanjing First Hospital, Nanjing Medical University.
• Patients who are able to provide written informed consent.
• Patients who are expected to undergo perioperative vascular aging assessment and postoperative renal function monitoring according to the study protocol.

You may not qualify if:

• Patients younger than 18 years.
• Patients with preoperative end-stage renal disease or maintenance dialysis.
• Patients who are unable to complete the study-specified vascular aging assessment.
• Patients who decline participation or withdraw informed consent.

Sponsors & Collaborators

• Nanjing First Hospital, Nanjing Medical University: lead

Study Sites (1)

Nanjing First Hospital, Nanjing Medical University

Nanjing, Jiangsu, 210006, China

Location

MeSH Terms

Conditions

Postoperative Complications; Acute Kidney Injury

Condition Hierarchy (Ancestors)

Pathologic Processes; Pathological Conditions, Signs and Symptoms; Renal Insufficiency; Kidney Diseases; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases

Central Study Contacts

F Hu

CONTACT

+8615162614385; feifanhu0722@foxmail.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: July 22, 2026
• First Posted: July 27, 2026
• Study Start: July 1, 2026
• Primary Completion (Estimated): February 21, 2027
• Study Completion (Estimated): December 28, 2027
• Last Updated: July 27, 2026

Record last verified: 2026-07

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)