Preoperative Ankle-Brachial Index and Renal Adverse Events After Acute Type A Aortic Dissection Surgery

NCT07668830 | Completed

• 1 other identifier: KY20260604-KS-05
• Study Type: observational
• Target: 516
• Locations: 1 country
• Sites: 1

Brief Summary

This retrospective cohort study will evaluate whether a high preoperative ankle-brachial index is associated with postoperative renal adverse events in patients with acute Stanford type A aortic dissection who underwent surgical repair. The ankle-brachial index is a noninvasive vascular measurement that may reflect arterial stiffness and vascular calcification. A high ankle-brachial index may indicate abnormal vascular aging and impaired vascular compliance. The study will use existing clinical data from patients treated at Nanjing First Hospital, Nanjing Medical University, between January 2021 and February 2024. No intervention will be assigned as part of this study. The primary aim is to examine the association between a preoperative ankle-brachial index of 1.4 or higher and the risk of acute kidney injury within 7 days after surgery.

Conditions

Aortic Dissection Type A; Acute Kidney Injury Cardiac Surgery

Keywords

Ankle-Brachial Index; Acute Stanford Type A Aortic Dissection; Renal Adverse Events; Retrospective Cohort Study; Arterial Stiffness

Outcome Measures

Primary Outcomes (1)

• Postoperative Acute Kidney Injury

  Postoperative acute kidney injury was defined according to serum creatinine-based Kidney Disease: Improving Global Outcomes criteria. Acute kidney injury was identified if serum creatinine increased by at least 0.3 mg/dL within 48 hours after surgery or increased to at least 1.5 times the baseline value within 7 days after surgery.

  Within 7 days after surgery

Secondary Outcomes (1)

• Postoperative Acute Kidney Disease

  Within 7 to 90 days after surgery

Study Arms (2)

High Ankle-Brachial Index Group

Patients with acute Stanford type A aortic dissection who underwent surgical repair and had a preoperative ankle-brachial index of 1.4 or higher.

Other: Preoperative Ankle-Brachial Index

Reference Ankle-Brachial Index Group

Patients with acute Stanford type A aortic dissection who underwent surgical repair and had a preoperative ankle-brachial index lower than 1.4.

Other: Preoperative Ankle-Brachial Index

Interventions

Preoperative Ankle-Brachial Index OTHER

Preoperative ankle-brachial index was measured as part of routine clinical assessment. Patients were categorized according to whether the ankle-brachial index was 1.4 or higher. No intervention was assigned by the study protocol.

High Ankle-Brachial Index Group; Reference Ankle-Brachial Index Group

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The study population will include adult patients with acute Stanford type A aortic dissection who underwent surgical repair at Nanjing First Hospital, Nanjing Medical University, between January 2021 and February 2024. Eligible patients will be identified from existing hospital medical records. Patients will be included if preoperative ankle-brachial index data and perioperative renal function data are available.

You may qualify if:

• Patients diagnosed with acute Stanford type A aortic dissection.
• Patients who underwent surgical repair for acute Stanford type A aortic dissection at Nanjing First Hospital, Nanjing Medical University, between January 2021 and February 2024.
• Patients aged 18 years or older.
• Patients with available preoperative ankle-brachial index data.
• Patients with available perioperative renal function data for assessment of postoperative renal outcomes.

You may not qualify if:

• Patients younger than 18 years.
• Patients without available preoperative ankle-brachial index data.
• Patients without sufficient perioperative serum creatinine data to assess postoperative acute kidney injury.
• Patients with preoperative end-stage renal disease or maintenance dialysis.
• Patients with incomplete key clinical data required for the main analysis.

Sponsors & Collaborators

• Nanjing First Hospital, Nanjing Medical University: lead

Study Sites (1)

Nanjing First Hospital, Nanjing Medical University

Nanjing, Jiangsu, 210006, China

Location

Study Officials

• Yali Ge

  Nanjing First Hospital, Nanjing Medical University

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: June 21, 2026
• First Posted: June 25, 2026
• Study Start: January 1, 2021
• Primary Completion: February 29, 2024
• Study Completion: February 29, 2024
• Last Updated: June 29, 2026

Record last verified: 2026-06

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)