RePer-AGE: Reorganization of Visuo-cognitive Functions Based on Peripheral Vision With Aging

NCT07727369 | Not Yet Recruiting

• 3 other identifiers: 38RC25.0395ANR-25-CE28-63332026-A00492-49
• Study Type: interventional
• Target: 160
• Locations: 1 country
• Sites: 1

Brief Summary

The RePer-AGE study investigates how central and peripheral vision contribute to visual recognition and how these mechanisms change with normal aging. The study is based on the hypothesis that peripheral vision provides rapid global information that supports visual recognition through predictive mechanisms. Healthy young adults (18-30 years) and older adults (60-85 years) will undergo visual psychophysical testing, ophthalmological examinations, and, for a subset of participants, functional magnetic resonance imaging (fMRI). The results are expected to improve our understanding of age-related changes in visuo-cognitive functions and provide reference data for future studies on age-related visual disorders.

Conditions

Aging; Visual Perception; Cognition

Keywords

Healthy Aging; Peripheral vision; Central vision; Visual recognition; Predictive processing; Psychophysics; Retinal sensitivity; fMRI

Outcome Measures

Primary Outcomes (1)

• Behavioral performance during scene categorization tasks

  Behavioral performance will be assessed using accuracy and response time during computerized scene categorization tasks evaluating (1) central versus peripheral vision (EXC paradigm) and (2) semantic congruency between peripheral and central vision (VPC paradigm). Comparisons will be performed between young and older adults.

  Baseline (single experimental session)

Secondary Outcomes (2)

• Retinal sensitivity

  Baseline

• Brain activation during visual recognition

  Baseline

Study Arms (2)

Psychophysics and Ophthalmology

EXPERIMENTAL

Participants undergo psychophysical visual recognition tasks together with ophthalmological examinations, including retinal sensitivity assessment by automated perimetry and low-luminance visual acuity testing.

Behavioral: Psychophysical visual recognition tasks; Diagnostic Test: Ophthalmological assessment

Psychophysics and Functional MRI

EXPERIMENTAL

Participants undergo psychophysical visual recognition tasks while functional magnetic resonance imaging (fMRI) is performed to investigate the neural mechanisms underlying visual recognition and predictive processing.

Behavioral: Psychophysical visual recognition tasks; Diagnostic Test: Functional magnetic resonance imaging (fMRI)

Interventions

Psychophysical visual recognition tasks BEHAVIORAL

Computerized visual recognition tasks assessing the respective contributions of central and peripheral vision to scene recognition and predictive visual processing.

Psychophysics and Functional MRI; Psychophysics and Ophthalmology

Ophthalmological assessment DIAGNOSTIC_TEST

Ophthalmological examinations including retinal sensitivity (Humphrey automated perimetry) and low-luminance visual acuity.

Psychophysics and Ophthalmology

Functional magnetic resonance imaging (fMRI) DIAGNOSTIC_TEST

Functional MRI performed during psychophysical visual recognition tasks to assess brain activity associated with visual recognition and predictive visual processing.

Psychophysics and Functional MRI

Eligibility Criteria

• Age: 18 Years - 85 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Healthy young adults aged 18 to 30 years or healthy older adults aged 60 to 85 years.
• Normal or corrected-to-normal visual acuity.
• No ophthalmological disease affecting visual function.
• For participants aged 60 years or older: Mini-Mental State Examination (MMSE) score ≥23.
• Affiliated with a national health insurance system.
• Written informed consent.
• Individuals protected under French regulations governing research involving human participants.
• Employees or individuals under the direct authority of the investigators.
• History of neurological or psychiatric disorders likely to affect visual or cognitive functions.
• Current treatment likely to alter visual function or vigilance.
• MRI contraindications (metallic implants, pacemaker, severe claustrophobia, or other MRI safety contraindications) for participation in the MRI arm only.

Sponsors & Collaborators

• University Hospital, Grenoble: lead
• Centre National de la Recherche Scientifique, France: collaborator
• University Grenoble Alps: collaborator
• National Research Agency, France: collaborator

Study Sites (1)

CHU Grenoble Alpes

Grenoble, Isère, 38043, France

Location

Related Publications (4)

• Faurite C, Aprile E, Kauffmann L, Mermillod M, Gallice M, Chiquet C, Cottereau BR, Peyrin C. Interaction between central and peripheral vision: Influence of distance and spatial frequencies. J Vis. 2024 Jan 2;24(1):3. doi: 10.1167/jov.24.1.3.

  PMID: 38190145 BACKGROUND

• Peyrin C, Roux-Sibilon A, Trouilloud A, Khazaz S, Joly M, Pichat C, Boucart M, Krainik A, Kauffmann L. Semantic and Physical Properties of Peripheral Vision Are Used for Scene Categorization in Central Vision. J Cogn Neurosci. 2021 Apr 1;33(5):799-813. doi: 10.1162/jocn_a_01689.

  PMID: 34449843 BACKGROUND

• Trouilloud A, Kauffmann L, Roux-Sibilon A, Rossel P, Boucart M, Mermillod M, Peyrin C. Rapid scene categorization: From coarse peripheral vision to fine central vision. Vision Res. 2020 May;170:60-72. doi: 10.1016/j.visres.2020.02.008. Epub 2020 Apr 4.

  PMID: 32259648 BACKGROUND

• Roux-Sibilon A, Peyrin C, Greenwood JA, Goffaux V. Radial bias in face identification. Proc Biol Sci. 2023 Jun 28;290(2001):20231118. doi: 10.1098/rspb.2023.1118. Epub 2023 Jun 28.

  PMID: 37357864 BACKGROUND

MeSH Terms

Interventions

Magnetic Resonance Imaging

Intervention Hierarchy (Ancestors)

Tomography; Diagnostic Imaging; Diagnostic Techniques and Procedures; Diagnosis

Central Study Contacts

Carole Peyrin, PhD

CONTACT

0033615351350; carole.peyrin@univ-grenoble-alpes.fr

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: Participants are assigned to one of two experimental arms according to the study procedures (psychophysics with ophthalmology or psychophysics with functional MRI). Both young and older adults are included in each arm.

Study Record Dates

• First Submitted: July 21, 2026
• First Posted: July 27, 2026
• Study Start (Estimated): September 1, 2026
• Primary Completion (Estimated): March 1, 2030
• Study Completion (Estimated): September 1, 2030
• Last Updated: July 27, 2026

Record last verified: 2026-07

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL, ANALYTIC CODE
• Time Frame: IPD and supporting information will be available after publication of the primary study results. Data will remain available for as long as they are maintained in the designated data repository, in accordance with the study Data Management Plan and institutional policies.
• Access Criteria: De-identified individual participant data will be made available to researchers for scientifically sound research purposes, in accordance with the study Data Management Plan, applicable legal and ethical requirements, and institutional policies.

Locations

FR (1)