Brain Correlates of Visual Processing of Emotional Scenes in ACTion and EMOtional Judgments During Normal VIeillissement

NCT03969043 | Completed

• 2 other identifiers: 38RC18.2152018-A02572-53
• Study Type: interventional
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

It is accepted that emotional events engage more attention and are detected and identified faster than neutral events. The same is true of negative events with regard to positive events. At the cerebral level, this facilitation results in greater activation of brain regions involved in visual and emotional processing. In normal aging, the preference for the negative stimuli (named negativity bias) tends to disappear and, sometimes, to shifts towards a preference for positive stimuli compared to both the negative and neutral stimuli (positivity bias). Most studies have assessed the age effect on emotional processing using tasks which require the identification of a personal emotional experience or the emotions of others. Although many studies suggest a strong link between emotion and action, relatively little is known about the age effect on emotional processing when the task requires the identification of a tendency to action (i.e. preparation of the individual to react and direction of action - example: fear prepares to avoid danger). ACTEMOVI project aims to identify the brain bases and neural networks involved in the processing of emotional visual information in normal aging when performing emotional appraisal and action-oriented tasks, through a functional MRI study.

Conditions

Aging

Outcome Measures

Primary Outcomes (1)

• Brain activations and connectivities involved in the processing of emotional visual information during normal aging when performing emotional assessment and action-to-action tasks.

  Variables measured from functional MRI data: * Statistical maps of brain regions activated in the whole brain for different contrasts of interest for each group of participants (young and old) * Statistical activation maps on regions of interest such as amygdala for the different contrasts of interest for each group of participants * Functional connectivity between brain regions activated in the whole brain on the basis of correlations and on the basis of graph theory, for different contrasts of interest for each group of participants. Functional connectivity analyzes will be coupled with an analysis of structural connectivity based on Voxel morphometric measurements to voxel of anatomical MRI and Diffusion Tension Imaging data to take account of anatomical differences between age groups. The correlation links between functional and structural connectivities will also be evaluated.

  2 hours

Study Arms (2)

Young volunteers

EXPERIMENTAL

Volunteers between 18 ans 45 years old Interventions: task scans (n=4), anatomical MRI, Resting state functional scan, Diffusion Tension Imaging, Perfusion imaging.

Other: MRI

Older Volunteers

EXPERIMENTAL

Volunteers between 60 ans 85 years old Interventions: task scans (n=4), anatomical MRI, Resting state functional scan, Diffusion Tension Imaging, Perfusion imaging.

Other: MRI

Interventions

MRI OTHER

The MRI examination will consist of a series of acquisition scans: * Scanning Scan: for positioning the functional volume of interest. * Task Scans: for exploring cerebral activation in emotional and action appraisal tasks during viewing high and low arousal stimuli and a localizer task ". * Anatomical MRI: for analyzing the functional images, and measuring volumes of gray and white substances. * Resting state functional scan: for exploring cerebral activation during a rest activity. * Diffusion Tension Imaging: for measuring structural connectivity. * Perfusion imaging: scan for ensuring good perfusion conditions All functional acquisitions will be performed in multi-slices in echoplanar mode using gradient echo sequences allowing the exploitation of the BOLD contrast.

Older Volunteers; Young volunteers

Eligibility Criteria

• Age: 18 Years - 85 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Participant aged between 18 and 45 and between 60 and 85 years old
• Visual acuity normal or corrected to normal
• Affiliation to a social security scheme (copy of the vital card in support)
• Signed informed consent
• Medical examination before taking part in the MRI examination
• Mini-Mental-State Examination Score (MMSE)\> 23/30
• Scale score of Beck depression ≤ 4

You may not qualify if:

• Unprotected Majors unable to express their consent
• Protected Major (Persons mentioned in Articles L1121-5,6 and 8 of the Public Health Code)
• Significant hearing or motor impairment
• Neuropsychiatric or neurological pathology past or present (except benign epilepsy)
• Taking narcotics and / or drugs for neurocognitive purposes
• Existence of a severe condition in general (cardiac, respiratory, hematological, renal, hepatic, cancerous)

Sponsors & Collaborators

• University Hospital, Grenoble: lead
• Laboratoire de Psychologie et NeuroCognition: collaborator

Study Sites (1)

CHU Grenoble-Alpes

Grenoble, France

Location

Related Publications (1)

• Poncet E, Nicolas G, Guyader N, Moro E, Campagne A. Spatio-temporal attention toward emotional scenes across adulthood. Emotion. 2023 Sep;23(6):1726-1739. doi: 10.1037/emo0000891. Epub 2022 Nov 28.

  PMID: 36441998 RESULT

Study Officials

• Monica BACIU

  Grenoble Alpes University Hospital

  PRINCIPAL INVESTIGATOR

• Aurélie Campagne

  University Grenoble Alps

  STUDY DIRECTOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: December 12, 2018
• First Posted: May 31, 2019
• Study Start: May 10, 2019
• Primary Completion: December 3, 2021
• Study Completion: December 3, 2021
• Last Updated: December 22, 2025

Record last verified: 2025-12

Data Sharing

• IPD Sharing: Will not share

Locations

FR (1)