NCT07724730

Brief Summary

Stroke is one of the leading causes of long-term disability worldwide. Among survivors, limitations in lower limb motor function, balance, and proprioception significantly affect their independence and quality of life. There is a growing need for targeted rehabilitation strategies for stroke survivors, who often experience lower limb impairments that limit independence during a highly active stage of life. Task-oriented training (TOT) helps patients practice real-life movements, while rhythmic auditory stimulation (RAS), such as metronome beats, can guide and improve their timing and coordination.

Trial Health

77
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
38

participants targeted

Target at P25-P50 for not_applicable stroke

Timeline
0mo left

Started Jun 2025

Geographic Reach
1 country

1 active site

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Progress99%
Jun 2025Aug 2026

Study Start

First participant enrolled

June 1, 2025

Completed
1.1 years until next milestone

First Submitted

Initial submission to the registry

July 21, 2026

Completed
3 days until next milestone

First Posted

Study publicly available on registry

July 24, 2026

Completed
6 days until next milestone

Primary Completion

Last participant's last visit for primary outcome

July 30, 2026

Completed
6 days until next milestone

Study Completion

Last participant's last visit for all outcomes

August 5, 2026

Expected
Last Updated

July 24, 2026

Status Verified

July 1, 2026

Enrollment Period

1.2 years

First QC Date

July 21, 2026

Last Update Submit

July 21, 2026

Conditions

Stroke

Keywords

Rhythmic Auditory StimulationTask-Oriented TrainingBalanceProprioceptionLower Extremity FunctionMotivationRehabilitation Adherence

Outcome Measures

Primary Outcomes (5)

  • Lower Limb Motor Function

    Lower Extremity Function (LEFS)

    Baseline and Week 8

  • Dynamic Balance

    Time up and Go Test

    Baseline and Week 8

  • Proprioception

    Joint Position Sense Test

    Baseline and post 8 weeks

  • motivation

    Stroke Rehabilitation Motivation Scale (SRMS)

    Baseline and post 8 weeks

  • adherence

    Rehabilitation Adherence Questionnaire (RAQ)

    Baseline and post 8 weeks

Study Arms (2)

Group A - Task-Oriented Training + Rhythmic Auditory Stimulation

EXPERIMENTAL

* 30-minute TOT session + RAS (60-110 BPM progression) * Functional gait tasks, obstacle walking, stair climbing, balance tasks * 5 days/week for 8 weeks * Plus 30-minute baseline physiotherapy

Other: Task-Oriented Training + Rhythmic Auditory Stimulation

Group B - Task-Oriented Training Only

ACTIVE COMPARATOR

* Same TOT structure without rhythmic cues * Functional lower limb tasks, balance training, gait practice * 5 days/week for 8 weeks * Plus 30-minute baseline physiotherapy

Other: Task-Oriented Training Only

Interventions

Task-Oriented Training + Rhythmic Auditory StimulationOTHER

* 30-minute TOT session + RAS (60-110 BPM progression) * Functional gait tasks, obstacle walking, stair climbing, balance tasks * 5 days/week for 8 weeks * Plus 30-minute baseline physiotherapy

Group A - Task-Oriented Training + Rhythmic Auditory Stimulation
Task-Oriented Training OnlyOTHER

* Same TOT structure without rhythmic cues * Functional lower limb tasks, balance training, gait practice * 5 days/week for 8 weeks * Plus 30-minute baseline physiotherapy

Group B - Task-Oriented Training Only

Eligibility Criteria

Age40 Years - 60 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64)

You may qualify if:

  • Age 40-60 years
  • First-time ischemic or hemorrhagic stroke
  • Subacute stroke (\<6 months)
  • Brunnstrom stage ≥ 3 (lower limb)
  • Able to walk 10 meters independently or with minimal support
  • Able to follow simple commands

You may not qualify if:

  • Severe aphasia
  • Other neurological disorders (Parkinson's, TBI)
  • Uncontrolled cardiovascular issues (BP \> 180 mmHg, arrhythmias)
  • Severe visual, auditory, or orthopedic impairments
  • Musculoskeletal injuries or medical conditions limiting participation
  • Diabetes, hypertension, fractures, surgeries, OA, RA

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Civil Hospital Daska, Pakistan

Daska Kalan, Pakistan

RECRUITING

MeSH Terms

Conditions

Stroke

Condition Hierarchy (Ancestors)

Cerebrovascular DisordersBrain DiseasesCentral Nervous System DiseasesNervous System DiseasesVascular DiseasesCardiovascular Diseases

Study Officials

  • Aiza Yousaf, MS-OMPT

    Riphah International University

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Imran Amjad, PhD

CONTACT

03324390125imran.amjad@riphah.edu.pk

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
OUTCOMES ASSESSOR
Masking Details
An independent assessor, who is blinded to the group allocations, will be responsible for evaluating study outcomes.
Purpose
TREATMENT
Intervention Model
PARALLEL
Model Details: Randomized Clinical Trial
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

July 21, 2026

First Posted

July 24, 2026

Study Start

June 1, 2025

Primary Completion

July 30, 2026

Study Completion (Estimated)

August 5, 2026

Last Updated

July 24, 2026

Record last verified: 2026-07

Data Sharing

IPD Sharing
Will not share

Locations

PA(1)