NCT07724665

Brief Summary

Cervicobrachialgia is a common musculoskeletal condition characterized by neck pain radiating into the upper limb due to neural and musculoskeletal dysfunctions. It is often associated with pain, functional disability, and increased neural mechanosensitivity, significantly affecting daily activities and quality of life. Various physiotherapy interventions have been used to manage this condition, including neural mobilization and scapulothoracic rehabilitation. However, evidence regarding the combined effectiveness of these interventions remains limited.

Trial Health

65
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Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
44

participants targeted

Target at P25-P50 for not_applicable

Timeline
5mo left

Started Jul 2026

Shorter than P25 for not_applicable

Status
not yet recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress17%
Jul 2026Dec 2026

Study Start

First participant enrolled

July 1, 2026

Completed
20 days until next milestone

First Submitted

Initial submission to the registry

July 21, 2026

Completed
3 days until next milestone

First Posted

Study publicly available on registry

July 24, 2026

Completed
4 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

November 30, 2026

Expected
1 month until next milestone

Study Completion

Last participant's last visit for all outcomes

December 30, 2026

Last Updated

July 24, 2026

Status Verified

July 1, 2026

Enrollment Period

5 months

First QC Date

July 21, 2026

Last Update Submit

July 21, 2026

Conditions

Cervico Brachialgia

Keywords

Disability, Mobilization, Neural, Pain, Scapula

Outcome Measures

Primary Outcomes (2)

  • Visual Analogue Scale (VAS)

    The VAS is a common, subjective measurement tool that is used to measure the level of pain severity using an 11-point range with zero (no pain) and ten (heaviest pain imaginable). Patients use a subjective scale to rate their pain verbally and the following scales apply to 1-3 mild, 4-6 moderate, and 7-10 severe pain.

    upto 6 weeks

  • Northwick Park Neck Pain Questionnaire (NPQ)

    The NPQ is a 9- questionnaire assessing neck pain disability with each question put on a scale of 0 to 4(code converted to percentage). It examines nocturnal sleep, activities during the day, and social goals. With cervicobrachialgia, it is used to measure functional restrictiveness such as neck/arm pain. Scores: 0-20 percent (light), 21-40 percent (moderate), \>40 percent (severe).

    upto 6 weeks

Secondary Outcomes (3)

  • PainDETECT questionnaire (PD-Q)

    upto 6 weeks

  • Disability of Arm, Shoulder and Hand (DASH)

    upto 6 weeks

  • FABF Questionnaire (FABQ)

    upto 6 weeks

Study Arms (2)

Scapulothoracic intervention with Neural Mobilization

EXPERIMENTAL

Group A received Scapulothoracic intervention with Neural Mobilization

Other: Scapulothoracic intervention with Neural Mobilization

Neural Mobilization

ACTIVE COMPARATOR

Group B received Neural Mobilization alone.

Other: Neural Mobilization

Interventions

Scapulothoracic intervention with Neural MobilizationOTHER

Neural Mobilization: Pain-free tension 1. Scapular Mobilization: * Grades III-IV joint mobs (elevation/depression/retraction) * 3 sets × 10 reps 2. Strengthening: * Serratus punches (progress to resistance bands) * Lower trap raises (prone Y-lifts) * 3 sets × 12 reps 3. Neural Mobilization: * ULNT1 sliding technique (6 sec hold/6 sec rest)

Scapulothoracic intervention with Neural Mobilization
Neural MobilizationOTHER

Neural Mobilization: Pain-free tension 1. Cervical Isometrics: * 4-way neck contractions (5-sec hold) * 3 sets × 10 reps 2. Postural Education: • Ergonomics training 3. Modalities: • TENS (80Hz, 100μs) or moist heat pack 4. Neural Mobilization: * ULNT1 (same as Group A)

Neural Mobilization

Eligibility Criteria

Age30 Years - 50 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64)

You may qualify if:

  • Cervicobrachial pain
  • Females and males
  • Aged 30-50 years
  • Able to communicate and follow the instructions
  • Able to perform cervical exercises according to cervicogenic pain

You may not qualify if:

  • Negative neurodynamic test
  • Neck and upper extremity surgery
  • Vertebral instability
  • Vertebral spine infection
  • Neurological disease of genetic, infection, or neuroplastic origin
  • Inflammatory or systemic disease
  • VBI symptoms
  • Rheumatoid arthritis
  • Subjects with presence of any fractures.
  • Heart/diabetic patient

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Related Publications (10)

  • Wagner FM. [Somatic dysfunction of the cervical spine and its complex clinical picture : The fundamentals of diagnostics of cervicobrachialgia and cervicocephalic syndrome through manual medicine]. Orthopade. 2022 Apr;51(4):263-273. doi: 10.1007/s00132-022-04228-7. Epub 2022 Mar 3. German.

    PMID: 35238967BACKGROUND

  • Sanchez AC, Requena JBS, Pantaleaon LAL, Esqueda ATI, Raidi VMV, Gallardo IR, et al. # 36401 Post-traumatic compressive C6 cervicobrachialgia, not all that glitters is gold. BMJ Publishing Group Ltd; 2023.

    BACKGROUND

  • Kerimova EK, Isaikin AI, Romanova AS, Bashlachev MG, Mouki K. Cervicalgia and cervicobrachialgia in periarticular cyst at the cervical level. Case report. Consilium Medicum. 2025;27(02):94-8.

    BACKGROUND

  • Thomson S, Ainsworth G, Selvanathan S, Brown S, Croft J, Kelly R, Mujica-Mota R, Rousseau N, Higham R, Stocken D. Clinical and cost-effectiveness of PCF versus ACD in the treatment of cervical brachialgia (FORVAD trial). Br J Neurosurg. 2024 Feb;38(1):141-148. doi: 10.1080/02688697.2023.2267119. Epub 2024 Jan 27.

    PMID: 37807634BACKGROUND

  • Fujastawan IGV. Management of Physiotherapy in Case of Brachialgia Due to Cervical Spondyloarthrosis. Science Midwifery. 2022;10(2):755-8.

    BACKGROUND

  • Rani A, Chopra J, Singh RR, Bajpai PK. Prevalence of various anomalies of costal element at cervico-thoracic junction in and around lucknow region of uttarpradesh: A radiological study. Biomed Res. 2021;32(1):7-14.

    BACKGROUND

  • AHMED AA, SHABAN M. Conservative Treatment of Cervical Discs without Myelopathy: A Three Years Follow-up. The Medical Journal of Cairo University. 2023;91(03):403-7.

    BACKGROUND

  • Thomson S, Ainsworth G, Selvanathan S, Kelly R, Collier H, Mujica-Mota R, Talbot R, Brown ST, Croft J, Rousseau N, Higham R, Al-Tamimi Y, Buxton N, Carleton-Bland N, Gledhill M, Halstead V, Hutchinson P, Meacock J, Mukerji N, Pal D, Vargas-Palacios A, Prasad A, Wilby M, Stocken D. Posterior cervical foraminotomy versus anterior cervical discectomy for Cervical Brachialgia: the FORVAD RCT. Health Technol Assess. 2023 Oct;27(21):1-228. doi: 10.3310/OTOH7720.

    PMID: 37929307BACKGROUND

  • Korman DV, Yushmanov IG. The influence of osteopathic correction to the level of stress in patients with cervicobrachialgia. Российский остеопатический. 2020:56.

    BACKGROUND

  • Ilić J, Kostić A, Ilić M, Nikolov V, Stojanović N, Todorović S. Cervicobrachial syndrome: Prevalence and clinical correlation with coronavirus 2019 disease among hospitalized patients. Acta Medica Medianae. 2024;63(3).

    BACKGROUND

MeSH Terms

Conditions

Pain

Condition Hierarchy (Ancestors)

Neurologic ManifestationsSigns and SymptomsPathological Conditions, Signs and Symptoms

Study Officials

  • Ramish Safraz

    Riphah International University

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Sumrod Akram

CONTACT

03324806143samrood.akram@riphah.edu.pk

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
OUTCOMES ASSESSOR
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

July 21, 2026

First Posted

July 24, 2026

Study Start

July 1, 2026

Primary Completion (Estimated)

November 30, 2026

Study Completion (Estimated)

December 30, 2026

Last Updated

July 24, 2026

Record last verified: 2026-07

Data Sharing

IPD Sharing
Will not share