Effectiveness of Combined Neural Mobilization With Manual Myofascial Release for Sciatic Pain Relief

NCT06947785 | Completed DMC

• 1 other identifier: REC-01004 Anwar Ullah
• Study Type: interventional
• Target: 48
• Locations: 1 country
• Sites: 1

Brief Summary

This study will address to evaluate and compare both Neural mobilization and Manual Myofascial Release of piriformis and Lumbar muscles in sciatic pain with the aim of evaluating and identifying the most effective intervention for managing this specific condition, and provide valuable insights into the effectiveness, mechanisms, and practical considerations associated with these interventions, ultimately contributing to evidence based and patient centered care.

Conditions

Sciatica

Keywords

Neural Mobilization; Myofascial Release; Sciatic Pain

Outcome Measures

Primary Outcomes (4)

• Numerical pain rating scale

  A subjective pain assessment tool where patients rate their pain intensity on a scale from 0 (no pain) to 10 (worst imaginable pain).

  Four Weeks

• Universal Goniometer

  Joint range of motion will be measured using a Universal Goniometer in degrees (°). Each joint movement will be assessed individually. The goniometer will be used following standardized procedures as per the American Academy of Orthopaedic Surgeons (AAOS) guidelines. Unit of Measure is degrees.

  Four Weeks

• Patient-Specific Functional Scale

  The Patient-Specific Functional Scale is a validated patient-reported outcome measure used to assess functional limitations based on activities identified by the patient. Participants will rate their ability to perform 3-5 self-selected activities that are important to them, using an 11-point scale ranging from 0 to 10. Minimum score: 0 (indicating the patient is unable to perform the activity) Maximum score: 10 (indicating the patient can perform the activity at their prior level with no difficulty) Interpretation: Higher scores indicate better functional status. The average score across all selected activities will be used for analysis.

  Four Weeks

• SLR (Straight Leg Raise)

  A clinical test used to assess sciatic nerve irritation or lumbar radiculopathy by raising the extended leg while the patient lies supine.

  Four Weeks

Study Arms (3)

Combined Neural Mobilization with Manual myofascial Release

EXPERIMENTAL

Combined neural mobilization of Sciatic nerve and manual myofascial release of piriformis and back muscles will be given to this group.

Other: Combined Neural Mobilization with Manual myofascial Release

Neural Mobilization

ACTIVE COMPARATOR

Only neural mobilization of Sciatic nerve will be given to this group.

Other: Neural Mobilization

Manual Myofascial Release

ACTIVE COMPARATOR

Only manual myofascial release of piriformis and back muscles will be given to this group.

Other: Manual Myofascial Release

Interventions

Combined Neural Mobilization with Manual myofascial Release OTHER

Combined neural mobilization with manual myofascial release will be provided to each subject.

Also known as: Neural Mobilization, Manual Myofascial Release

Combined Neural Mobilization with Manual myofascial Release

Neural Mobilization OTHER

neural mobilization will be provided to each subject.

Also known as: Combined Neural Mobilization with Manual myofascial Release, Manual Myofascial Release

Neural Mobilization

Manual Myofascial Release OTHER

Manual myofascial release will be provided to each subject.

Also known as: Combined Neural Mobilization with Manual myofascial Release, Neural Mobilization

Manual Myofascial Release

Eligibility Criteria

• Age: 20 Years - 40 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• Clinically diagnosed unilateral sciatic pain for \>3 months.
• Positive Straight Leg Raise (SLR).

You may not qualify if:

• \- Participants fall in this category would be excluded of the study.
• Recent spinal surgery or trauma.
• Neurological deficits or systemic conditions affecting the nervous system.
• Any other red flags

Sponsors & Collaborators

• Riphah International University: lead

Study Sites (1)

Riphah International University, Malakand

Chakdara, KPK, 18800, Pakistan

Location

MeSH Terms

Conditions

Sciatica

Condition Hierarchy (Ancestors)

Sciatic Neuropathy; Mononeuropathies; Peripheral Nervous System Diseases; Neuromuscular Diseases; Nervous System Diseases; Neuralgia; Pain; Neurologic Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Officials

• Amnah Anum, MSPT

  Riphah International University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: April 7, 2025
• First Posted: April 27, 2025
• Study Start: April 15, 2025
• Primary Completion: October 3, 2025
• Study Completion: December 31, 2025
• Last Updated: April 8, 2026

Record last verified: 2026-04

Data Sharing

• IPD Sharing: Will not share

Locations

PA (1)