Diagnostic Accuracy of ONSD, ODE, and the Crescent Sign

NCT07719842 | Not Yet Recruiting

• 1 other identifier: MuratYazıcı
• Study Type: interventional
• Target: 10
• Locations: 1 country
• Sites: 1

Brief Summary

Our aim was to determine the diagnostic accuracy of the ONSD, ODE, and crescent sign, as detected by POCUS, in identifying the clinical and radiological features of increased intracranial pressure.

Conditions

Assessment of ONSD, ODE and the Crescent Sign Using POCUS

Keywords

POCUS; ONSD; ODE; crescent sign

Outcome Measures

Primary Outcomes (1)

• Primary outcome

  The diagnostic value of ONSD, ODE and the crescent sign in increased intracranial pressure

  An average of 8 months

Study Arms (1)

Ultrasound assessment

OTHER

Diagnostic Test: Ultrasound assessment

Interventions

Ultrasound assessment DIAGNOSTIC_TEST

Determination of optic nerve sheath diameter (ONSD), optic disc elevation (ODE) and the presence of the crescent sign using bedside ultrasound

Ultrasound assessment

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may not qualify if:

• Patients under the age of 18
• Patients who have not undergone a cranial CT or cranial MRI
• Patients with orbital injuries
• Patients in whom ultrasonographic measurements cannot be performed
• Patients brought to ED following a cardiac arrest
• Patients who do not consent to diagnosis and treatment of their own volition

Sponsors & Collaborators

• Recep Tayyip Erdogan University Training and Research Hospital: lead

Study Sites (1)

Recep Tayyip Erdoğan University Rize Training and Research Hospital

Rize, Centrale, 53020, Turkey (Türkiye)

Location

Related Publications (5)

• Janitschke D, Stogbauer J, Lattanzi S, Brigo F, Lochner P. B-mode transorbital ultrasonography for the diagnosis of idiopathic intracranial hypertension: an updated systematic review and meta-analysis. Neurol Sci. 2023 Dec;44(12):4313-4322. doi: 10.1007/s10072-023-07016-z. Epub 2023 Aug 21.

  PMID: 37599314 BACKGROUND

• Lunia V, Kappagantu V, Bhoi SK, Sinha TP, Jamshed N, Kumar A, Ekka M, Mishra PR, Pandey S. Diagnostic Accuracy of Crescent Sign by Ultrasound in Identifying Increased Intracranial Pressure. J Ultrasound Med. 2026 Jul;45(7):1477-1484. doi: 10.1002/jum.70192. Epub 2026 Feb 3.

  PMID: 41631636 BACKGROUND

• Sahin A, Akilli NB, Koylu R. The test characteristics of ONSD and ODE tests in predicting the prognosis of patients with traumatic brain injury. Am J Emerg Med. 2026 May;103:170-175. doi: 10.1016/j.ajem.2026.02.015. Epub 2026 Feb 12.

  PMID: 41720038 BACKGROUND

• Tessaro MO, Friedman N, Al-Sani F, Gauthey M, Maguire B, Davis A. Pediatric point-of-care ultrasound of optic disc elevation for increased intracranial pressure: A pilot study. Am J Emerg Med. 2021 Nov;49:18-23. doi: 10.1016/j.ajem.2021.05.051. Epub 2021 May 21.

  PMID: 34051397 BACKGROUND

• Marmarou A, Anderson RL, Ward JD, et al. Impact of ICP instability and hypotension on outcome in patients with severe head trauma. J Neurosurg 1991; 75:S59-S66.

  BACKGROUND

Central Study Contacts

Mümin M Yazici, Specialist

CONTACT

+9005364971612; mmuratyazici53@gmail.com

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: DIAGNOSTIC
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Emergency medicine specialist

Study Record Dates

• First Submitted: July 12, 2026
• First Posted: July 22, 2026
• Study Start: August 1, 2026
• Primary Completion (Estimated): December 31, 2026
• Study Completion (Estimated): January 31, 2027
• Last Updated: July 22, 2026

Record last verified: 2026-07

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)