JUgular Gating for Upright Level Adjustment and Targeted Enhancement of Cerebral Perfusion

NCT07665606 | Not Yet Recruiting

• 1 other identifier: CHUBX 2026/011
• Study Type: observational
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

Investigators aim to demonstrate that the evolution of intracranial pressure (ICP) is nonlinear and may be influenced by jugular vein collapse. This collapse is estimated to occur at the angle where the hydrostatic pressure of the blood column matches the central venous pressure, and it can be assessed using ultrasonography. This approach allows for the determination of an individualized tilt angle, optimizing cerebral perfusion pressure without compromising venous drainage.

Conditions

Intracranial Pressure; Critical Care

Keywords

Intracranial Pressure; jugular vein collapse; Critical care

Outcome Measures

Primary Outcomes (1)

• Intracranial pressure

  After the routine nursing care, during patient repositioning to 30 ° assessments are performed at 0, 10° 20° 30°, and at a calculated threshold angle α. At each angle intracranial pressure is recorded.

  At inclusion (day 0)

Secondary Outcomes (5)

• Cerebral perfusion pressure at 30° and at angle α (1)

  At inclusion (day 0)

• Cerebral perfusion pressure at 30° and at angle α (2)

  At inclusion (day 0)

• Cerebral perfusion pressure at 30° and at angle α (3)

  At inclusion (day 0)

• Intracranial pressure

  At inclusion (day 0)

• Variation in internal jugular vein luminal cross-sectional area.

  At inclusion (Day 0)

Study Arms (1)

Experimental group

Patients ≥ 18 years old hospitalized in the neurocritical care unit or the trauma unit in clinically stable condition allowing transient positional changes

Procedure: Ultrasound assessment

Interventions

Ultrasound assessment PROCEDURE

After the routine nursing care, during patient repositioning to 30 ° assessments are performed at 0, 10° 20° 30°, and at a calculated threshold angle α. At each angle intracranial pressure , cerebral perfusion pressure and ultrasound assessment of cerebral blood flow velocities and internal jugular vein cross-sectional area at three cervical levels are recorded.

Experimental group

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patient hospitalized in the neurocritical care unit or the trauma unit

You may qualify if:

• Patients ≥ 18 years old
• Hospitalized in the neurocritical care unit or the trauma unit
• Scheduled for nursing care requiring a supine position.
• Arterial catheter allowing continuous measurement of mean arterial pressure.
• Central venous catheter for continuous measurement of central venous pressure.
• External ventricular drain or intracranial pressure sensor for intracranial pressure monitoring.
• Bed with controlled inclination capability.
• Clinically stable condition allowing transient positional changes (as judged by the clinician).
• Not included, or planned to be included in another trial.

You may not qualify if:

• Contraindication to trunk mobilization.
• Being a minor or placed under supervision.
• Hemodynamic or respiratory instability.
• Uncontrolled intracranial hypertension, refractory arterial hypertension, or severe dysautonomia.
• Pregnancy or breastfeeding.
• Refusal to participate in the study.

Sponsors & Collaborators

• University Hospital, Bordeaux: lead

Study Sites (1)

Bordeaux university hospital

Bordeaux, France

Location

Study Officials

• Grégoire CANE, Dr

  University Hospital, Bordeaux

  PRINCIPAL INVESTIGATOR

Central Study Contacts

David ROURE

CONTACT

05 57 87 02 01; david.roure@chu-bordeaux.fr

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: June 4, 2026
• First Posted: June 24, 2026
• Study Start (Estimated): September 1, 2026
• Primary Completion (Estimated): March 31, 2027
• Study Completion (Estimated): March 31, 2027
• Last Updated: June 24, 2026

Record last verified: 2026-06

Locations

FR (1)