NCT07719049

Brief Summary

We aim to examine how FaceAge estimates (a measure of biological age based on facial features) change across different time points and identify factors that may influence these changes. This will help us understand the consistency and reliability of the FaceAge algorithm and allow us to make improvements.

Trial Health

77
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
10,000

participants targeted

Target at P75+ for all trials

Timeline
15mo left

Started Oct 2025

Geographic Reach
1 country

1 active site

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress40%
Oct 2025Oct 2027

Study Start

First participant enrolled

October 23, 2025

Completed
9 months until next milestone

First Submitted

Initial submission to the registry

July 17, 2026

Completed
5 days until next milestone

First Posted

Study publicly available on registry

July 22, 2026

Completed
1.2 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

October 1, 2027

Expected
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

October 1, 2027

Last Updated

July 22, 2026

Status Verified

May 1, 2026

Enrollment Period

1.9 years

First QC Date

July 17, 2026

Last Update Submit

July 17, 2026

Conditions

AgingFacial Aging

Keywords

Artificial IntelligenceAgingBiomarkers of Aging

Outcome Measures

Primary Outcomes (2)

  • FaceAge estimate(s)

    AI-generated FaceAge predictions for each photograph.

    Up to three years from the date of enrollment.

  • Changes in FaceAge estimates

    For those with more than one FaceAge estimate, we will evaluate the consistency of FaceAge estimates between photographs taken at different time intervals.

    Up to three years from the date of enrollment.

Study Arms (1)

Healthy volunteers

Individuals that are not currently/have never received care at any MGB affiliated institutions.

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Any healthy individual that has not/has never received care from any MGB affiliated institution.

You may qualify if:

  • The protocol enrolls healthy volunteers from the adult (age 18 and above) general population. All races and genders will be included.

You may not qualify if:

  • Any skin condition or recent facial injury that could affect facial appearance.
  • Inability to follow study instructions or provide informed consent.
  • Taking new or strong medication on the day of image capture could potentially affect appearance or alertness.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Brigham and Women's Hospital

Boston, Massachusetts, 02115, United States

RECRUITING

Central Study Contacts

Raymond Mak, MD

CONTACT

(617) 632-5734bwhfaceage@mgb.org

Fridolin Haugg, MS

CONTACT

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Target Duration
3 Years
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Professor of Radiation Oncology

Study Record Dates

First Submitted

July 17, 2026

First Posted

July 22, 2026

Study Start

October 23, 2025

Primary Completion (Estimated)

October 1, 2027

Study Completion (Estimated)

October 1, 2027

Last Updated

July 22, 2026

Record last verified: 2026-05

Data Sharing

IPD Sharing
Will not share

Locations

US(1)