Prevention of Chronic Postsurgical Pain in Chronic Opioid Users:

NCT07717151 | Recruiting

• 1 other identifier: PI2025_843_0191
• Study Type: interventional
• Target: 354
• Locations: 1 country
• Sites: 1

Brief Summary

Chronic opioid users undergoing surgery are at increased risk of CPSP, contributing to long-term disability, decreased quality of life, and prolonged opioid exposure. Existing preventive strategies remain limited, and early postoperative monitoring may represent a key opportunity for intervention. Evidence suggests that transitional pain services can improve outcomes by optimizing pain control and reducing long-term opioid consumption, but implementation is heterogeneous and often resource-intensive. Telemedicine offers a scalable alternative, enabling early specialized evaluation and timely therapeutic adjustments while maintaining accessibility. This randomized controlled trial will compare standard postoperative follow-up with standard follow-up plus a specialized teleconsultation performed between postoperative day 15 and 28. The intervention aims to detect insufficiently controlled pain, signs of neuropathic pain, or maladaptive opioid use, and to propose individualized therapeutic adjustments when required. Participants will be followed for 6 months. Primary assessment will occur at 3 months to determine CPSP incidence. Secondary assessments will include pain trajectory (intensity, neuropathic features, functional interference), opioid consumption and misuse, quality of life, and a descriptive medico- economic evaluation

Conditions

Transitional Pain Service; Chronic Postsurgical Pain; Chronic Opioid Users; Postoperative Pain; Perioperative Medicine

Keywords

Chronic postsurgical pain; chronic opioid users; transitional pain service; postoperative pain; perioperative medicine

Outcome Measures

Primary Outcomes (1)

• Incidence of chronic postsurgical pain (CPSP)

  Incidence of chronic postsurgical pain (CPSP) at 3 months, defined as: * new or aggravated postsurgical pain located at the surgical site or innervated territory, * persistent for ≥3 months, * intensity ≥3/10 (new pain) or increase ≥2/10 from baseline (aggravation), * with significant functional impact (≥3/10 on at least one Brief Pain Inventory interference item), * assessed at day 90 ±14.

  at 3 months

Secondary Outcomes (5)

• Pain trajectory

  at 3 months

• Pain trajectory

  at 6 months

• Opioid use

  at 3 months

• Opioid use

  at 6 months

• Descriptive medico-economic analysis

  at 6 months

Study Arms (2)

Standard care + specialized postoperative teleconsultation

EXPERIMENTAL

Standard care + specialized postoperative teleconsultation

Other: standard institutional perioperative management; Other: specialized teleconsultation

Standard postoperative care alone

ACTIVE COMPARATOR

Standard postoperative care alone

Other: standard institutional perioperative management

Interventions

specialized teleconsultation OTHER

Patients in the intervention arm participate in a specialized teleconsultation between postoperative day 15-28 to detect poorly controlled pain, neuropathic features, or opioid-related concerns, and to adjust treatment if needed.

Standard care + specialized postoperative teleconsultation

standard institutional perioperative management OTHER

standard institutional perioperative management

Standard care + specialized postoperative teleconsultation; Standard postoperative care alone

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Age ≥18 years
• Elective non-urgent surgery with expected moderate or higher postoperative pain
• Chronic preoperative opioid use
• Written informed consent
• affiliated with a national social security scheme

You may not qualify if:

• Ambulatory surgery
• Endoscopic or palliative surgery
• Patients receiving opioid substitution therapy
• Non-medical opioid use
• Intrathecal/epidural analgesia or implanted neurostimulator
• Legally protected adults
• Severe psychiatric or neurodegenerative disorders

Sponsors & Collaborators

• Centre Hospitalier Universitaire, Amiens: lead

Study Sites (1)

CHU Amiens-Picardie

Amiens, 80054, France

RECRUITING

MeSH Terms

Conditions

Pain, Postoperative

Condition Hierarchy (Ancestors)

Postoperative Complications; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Pain; Neurologic Manifestations; Signs and Symptoms

Central Study Contacts

Paul Tarpin, MD

CONTACT

33+3.22.08.79.80; Tarpin.paul@chu-amiens.fr

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: OTHER
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: July 9, 2026
• First Posted: July 21, 2026
• Study Start: January 14, 2026
• Primary Completion (Estimated): July 1, 2028
• Study Completion (Estimated): January 1, 2029
• Last Updated: July 21, 2026

Record last verified: 2026-07

Data Sharing

• IPD Sharing: Will not share

Locations

FR (1)