Effect of Erector Spinae Plane Block on Neuropathic Pain After Abdominal Hysterectomy

NCT07830706 | Completed

• 1 other identifier: 2021/2976
• Study Type: interventional
• Target: 200
• Locations: 1 country
• Sites: 1

Brief Summary

This study evaluated whether bilateral erector spinae plane block (ESPB) performed before abdominal hysterectomy could reduce postoperative pain and the development of chronic and neuropathic pain. Adult patients undergoing abdominal hysterectomy under general anesthesia were assigned to receive either bilateral ESPB with bupivacaine or standard perioperative analgesic management without ESPB. Postoperative pain was assessed during the early postoperative period and at 1 and 6 months after surgery. Chronic and neuropathic pain were evaluated at 1 and 6 months using validated pain assessment tools.

Conditions

Chronic Postsurgical Pain; Postoperative Pain

Outcome Measures

Primary Outcomes (1)

• Chronic postoperative pain severity at 6 months

  Chronic postoperative pain severity was assessed using the Numeric Rating Scale (NRS), ranging from 0 (no pain) to 10 (worst pain imaginable).

  6 months after surgery

Study Arms (2)

ESPB Group

EXPERIMENTAL

Participants assigned to the ESPB group received bilateral ultrasound-guided erector spinae plane block at the T8-T9 level before surgery, with 20 mL of 0.25% bupivacaine administered on each side, in addition to standard perioperative analgesic management.

Drug: Bupivacaine

Control Group

ACTIVE COMPARATOR

Participants assigned to the control group received standard perioperative analgesic management without erector spinae plane block.

Other: Standard Perioperative Analgesia

Interventions

Bupivacaine DRUG

0.25% bupivacaine, 20 mL administered bilaterally as part of ultrasound-guided erector spinae plane block at T8-T9.

ESPB Group

Standard Perioperative Analgesia OTHER

Participants received standard perioperative analgesic management according to the routine institutional protocol, without erector spinae plane block.

Control Group

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: female
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Adults aged 18-65 years
• American Society of Anesthesiologists (ASA) physical status I-III
• Body mass index (BMI) \<35 kg/m²
• Scheduled for elective total abdominal hysterectomy under general anesthesia
• Provided informed consent to participate in the study

You may not qualify if:

• Decompensated heart failure
• Severe respiratory distress
• Renal failure
• Hepatic failure
• History of opioid addiction
• Current anticoagulant use or bleeding diathesis
• Refusal to participate in the study

Sponsors & Collaborators

• Necmettin Erbakan University: lead

Study Sites (1)

Necmettin Erbakan University Medical Faculty Hospital Konya, Türkiye

Konya, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Pain, Postoperative

Interventions

Bupivacaine

Condition Hierarchy (Ancestors)

Postoperative Complications; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Pain; Neurologic Manifestations; Signs and Symptoms

Intervention Hierarchy (Ancestors)

Anilides; Amides; Organic Chemicals; Aniline Compounds; Amines

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Masking Details: The postoperative outcomes assessor was blinded to group allocation. Participants, the anesthesiologist performing the intervention, and the care providers were not blinded because of the nature of the intervention.
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Specialist Physician

Model Details: Model Description

Study Record Dates

• First Submitted: September 15, 2026
• First Posted: September 21, 2026
• Study Start: January 1, 2025
• Primary Completion: December 31, 2025
• Study Completion: December 31, 2025
• Last Updated: September 23, 2026

Record last verified: 2026-09

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)